Visual outcomes and safety of an extended depth-of-focus intraocular lens: results of a pivotal clinical trial

Chang, Daniel H.; Janakiraman, Devi Priya; Smith, Pamela J. Olúbùnmi; Buteyn, Anne; Domingo, Joy; Jones, Jason J.; Christie, William C.

doi:10.1097/j.jcrs.0000000000000747

Cited by 21 publications

(29 citation statements)

References 33 publications

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“…Similarly, the results of the static defocus curve also revealed a better static VA from − 0.5 D to − 3.0 D and a smoother curve from 0.0 D to − 2.0 D for the ZXR00 group. The result is similar to previous studies comparing ZXR00 and monofocal IOLs [ 5 , 19 ]. Laboratory measurements in an EDOF model eye revealed clearer images at the defocus positions from − 0.75 D to − 1.75 D, and the visualization of the light pathway illustrated elongated focus compared with the distinct single focus in monofocal IOLs [ 20 ].…”

Section: Discussionsupporting

confidence: 92%

“…Although multifocal IOLs liberate patients from spectacles when accomplishing near tasks, complaints such as dysphotopsias are reported [4]. The extended depth-of-focus (EDOF) IOL provides favorable distant and intermediate vision and useful near vision with a lower compromise of dysphotopsias [5,6]. The defocus curve test is crucial for evaluating the continuous visual function at different distances after implanting IOLs, especially functional ones [7].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens

Wang²,

Yu³

et al. 2023

Eye and Vis

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Background The aim of the study was to compare the dynamic defocus curve on patients post-implantation of the extended depth-of-focus (EDOF) and monofocal intraocular lens (IOL). Methods A total of 62 age-related cataract patients receiving phacoemulsification with implantation of TECNIS Symfony (ZXR00) or monofocal IOLs were enrolled. The binocular static and dynamic defocus curves with corrected distance visual acuity were evaluated at one month postoperatively. Results The ZXR00 group achieved significantly better intermediate (P = 0.044) and near (P = 0.017) visual acuity (VA) than the monofocal group. Two groups had similar uncorrected and corrected distance VA (P > 0.05, respectively). The dynamic defocus curve revealed a smoother decline from 0.0 D to − 2.0 D in the ZXR00 group. Defocused dynamic VA in the ZXR00 group was significantly better (P < 0.05) except at 0.0 D (P = 0.724) and − 0.5 D (P = 0.176). The area under the curve (P = 0.002) and corrected dynamic vision accommodation (P = 0.001) derived from the dynamic defocus curves were better in the ZXR00 group. A positive correlation was observed between defocused dynamic and static VA in both groups (P < 0.001). Multiple linear regression analysis indicated that defocused static VA and corrected dynamic vision accommodation were significant influential factors for the defocused dynamic VA from − 1.0 D to − 3.0 D (P < 0.05). Conclusions The EDOF IOL provided similar distance vision, better intermediate and near vision, and a better overall dynamic defocus curve than the monofocal IOL. The dynamic defocus curve may be comprehensively applied to evaluate the all-distance dynamic visual performance post-cataract surgery.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens

Wang²,

Yu³

et al. 2023

Eye and Vis

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“… 19 This corresponds to other studies where halo sizes differed ranging from 35 of 100 to 51 of 100. 20 , 27 , 30 …”

Section: Discussionmentioning

confidence: 99%

Clinical Performance of Extended Depth of Focus (EDOF) Intraocular Lenses – A Retrospective Comparative Study of Mini Well Ready and Symfony

Nowik¹,

Nowik²,

Kanclerz³

et al. 2022

OPTH

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Purpose Extended depth of focus intraocular (EDOF) IOLs form a bridge between single- and multifocal IOL design. This study aimed to compare clinical outcomes obtained after implanting two different optical designs of EDOF IOLs: the Mini Well Ready (SIFI Medtech, Catania, Italy) and Tecnis Symfony (Abbott Laboratories, Illinois, USA). Methods The retrospective observational study included 61 patients (122 eyes) who underwent bilateral implantation of the Mini Well Ready IOL (32 patients) or the Tecnis Symfony IOL (29 patients). The following preoperative and postoperative parameters were evaluated: spherical equivalent, anterior astigmatism, pupil size, monocular and binocular uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), monocular and binocular uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA), monocular and binocular uncorrected near visual acuity (UNVA) and distance-corrected near visual acuity (DCNVA). In the 6 months postoperative period, defocus curve, contrast sensitivity, photopic phenomena, and posterior capsule opacification were assessed. Results The patients receiving the Tecnis Symfony had slightly better monocular and binocular UDVA and CDVA than with the Mini Well Ready IOL, the differences were not statistically significant. Whereas the UIVA, DCIVA, UNVA, DCNVA, UNVA and DCNVA values were higher in the Mini Well Ready group, the differences were not significant. There were no significant between-group differences regarding the defocus curve for the vast majority of tested vergences. Dysphotopsias postoperatively were assessed at 6 months. Conclusion Patients receiving both the Mini Well Ready and Symfony IOLs had excellent visual acuity outcomes and spectacle independence.

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“…TECNIS Symfony, the most widely used type of EDOF IOL in clinical practice, is an example of a diffractive hydrophobic EDOF IOL that has an achromatic pattern, which can compensate for corneal chromatic aberration [ 12 , 14 – 16 ]. Previous studies have demonstrated that the TECNIS Symfony IOL showed great safety with low rates of posterior capsule opacification (PCO) and adverse events [ 17 , 18 ]. As this type of IOL has an aspheric anterior surface and a continuum of foci instead of separate foci, they are expected to decrease the incidence of photic phenomena such as halos [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Patient Outcomes following Implantation of Trifocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis

Guo

Wang

Hao

et al. 2021

Journal of Ophthalmology

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Purpose. The purpose is to compare the outcomes of implantation of trifocal intraocular lenses (TIOLs) and extended depth of focus (EDOF) intraocular lenses (IOLs). Methods. A comprehensive search of PubMed, Cochrane Library, EMBASE, and ClinicalTrial.gov was conducted in March 2020 to identify relevant studies. A meta-analysis of the results was performed. Patients implanted with EDOF IOLs or TIOLs in previous studies were included. The primary outcomes of the study were uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), and defocus curve. Results. TIOLs and EDOF IOLs provided comparable binocular UDVA (MD = -0.01, 95% CI: -0.04, 0.03, logMAR). However, EDOF IOLs provided better UIVA (MD: -0.08, 95% CI: -0.14, -0.01, logMAR) and worse UNVA (MD: 0.10, 95% CI: 0.06, 0.14, logMAR) than TIOLs. Fewer patients achieved spectacle independence after implantation of EDOF IOLs (RR: 0.74, 95% CI: 0.63, 0.87) than after implantation of TIOLs, especially for near vision (RR = 0.82, 95% CI: 0.68, 0.99). There was no statistically significant difference in contrast sensitivity (CS) under photopic or mesopic conditions with both IOLs. Patient satisfaction after implantation of both IOLs was high. Conclusion. EDOF IOLs and TIOLs provide comparable distance vision. However, EDOF IOLs provide better intermediate vision and worse near vision than TIOLs. The advantages of EDOF IOLs over TIOLs in terms of CS, aberrations, and visual disturbance are not significant. Patients are satisfied with both types of IOLs.

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Visual outcomes and safety of an extended depth-of-focus intraocular lens: results of a pivotal clinical trial

Abstract: Randomized comparison of the TECNIS Symfony (ZXR00) and the TECNIS 1-piece monofocal (ZCB00) intraocular lenses in cataract surgery demonstrates improved intermediate and near vision with TECNIS Symfony.

Cited by 21 publications

References 33 publications

Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens

Comparison of dynamic defocus curve on cataract patients implanting extended depth of focus and monofocal intraocular lens

Clinical Performance of Extended Depth of Focus (EDOF) Intraocular Lenses – A Retrospective Comparative Study of Mini Well Ready and Symfony

Comparison of Patient Outcomes following Implantation of Trifocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis

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