Clinical Performance of Extended Depth of Focus (EDOF) Intraocular Lenses – A Retrospective Comparative Study of Mini Well Ready and Symfony

Abstract

Purpose Extended depth of focus intraocular (EDOF) IOLs form a bridge between single- and multifocal IOL design. This study aimed to compare clinical outcomes obtained after implanting two different optical designs of EDOF IOLs: the Mini Well Ready (SIFI Medtech, Catania, Italy) and Tecnis Symfony (Abbott Laboratories, Illinois, USA). Methods The retrospective observational study included 61 patients (122 eyes) who underwent bilateral implantation of the Mini Well Ready IOL (32 patients) or the Tecnis Symfony IOL (29 patients). The following preoperative and postoperative parameters were evaluated: spherical equivalent, anterior astigmatism, pupil size, monocular and binocular uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), monocular and binocular uncorrected intermediate visual acuity (UIVA) and distance-corrected intermediate visual acuity (DCIVA), monocular and binocular uncorrected near visual acuity (UNVA) and distance-corrected near visual acuity (DCNVA). In the 6 months postoperative period, defocus curve, contrast sensitivity, photopic phenomena, and posterior capsule opacification were assessed. Results The patients receiving the Tecnis Symfony had slightly better monocular and binocular UDVA and CDVA than with the Mini Well Ready IOL, the differences were not statistically significant. Whereas the UIVA, DCIVA, UNVA, DCNVA, UNVA and DCNVA values were higher in the Mini Well Ready group, the differences were not significant. There were no significant between-group differences regarding the defocus curve for the vast majority of tested vergences. Dysphotopsias postoperatively were assessed at 6 months. Conclusion Patients receiving both the Mini Well Ready and Symfony IOLs had excellent visual acuity outcomes and spectacle independence.

Advanced Optical Wavefront Technologies to Improve Patient Quality of Vision and Meet Clinical Requests

“…The study carried out by Domínguez-Vicent et al demonstrated that MINI WELL is more defocus-tolerant for intermediate and near distances than TECNIS Symfony, in both photopic and scotopic conditions. This experimental result is consistent with the clinical outcomes, as reported by Nowik et al in their retrospective observational study [ 109 ]. Nowik et al compared MINI WELL with TECNIS Symfony from the clinical point of view; they found that MINI WELL provides a larger range of depth of focus than TECNIS Symfony, and the difference was statistically significant.…”

Clinical results after binocular implantation of a unique nondiffractive enhanced monofocal intraocular lens designed for enhanced monovision to increase the depth of focus

“…The distance VA and the intermediate VA at 1-month follow-up appear consistent with the reports of other EDoF IOLs of different designs. [ 7 8 9 ] The range of good vision provided by RayOne EMV from far to 45 cm is also comparable to the standard designs available today. [ 5 ]…”

“…The results of our study using RayOne EMV match the results of Nowik et al, who have performed a similar study with EDoF IOLs of related design. [ 7 ] They noted that high spectacle independence for distance and near was found in eyes that had Technis Symfony and SIFI Mini Well Ready IOLs.…”

Clinical and functional assessment of Acrysof Alcon Vivity extended depth of focus intraocular lenses

“…Good outcomes in terms of dysphotopsia are largely related to the modern nondiffractive X-wave technology, as many studies report that more undesirable dysphotopsia was experienced by patients with diffractive lenses. Nowik et al reported halo and glare phenomena in 40% and 3% of patients with a different model of non-diffractive Mini Well IOL implanted, respectively; worse outcomes were observed in patients with diffractive EDOF Symfony IOLs, with halo and glare occurring in 65.6% and 24% of patients, respectively [15]. It can be assumed that undesirable dysphotopic phenomena would be reduced if patients were asked about their occurrence over a period longer than 3 months.…”