Visual Outcomes After Implantation of Allogenic Lenticule in a 100-µm Pocket for Moderate to High Hyperopia: 2-Year Results

Abstract

PURPOSE: To investigate 2-year visual outcomes, stability, and predictability after allogenic lenticule implantation in a 100-µm pocket for moderate to high hyperopia correction. METHODS: In this prospective case series, 14 eyes of 9 patients with moderate to high hyperopia ranging from +3.00 to +8.00 diopters sphere were included between March and September 2018. Allogenic lenticules extracted from myopic small incision lenticule extraction were implanted into a pocket created by femtosecond laser at a 100-µm depth in recipients with hyperopia. All patients were followed up for 2 years. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, manifest refraction, corneal topography, Fourier-domain optical coherence tomography, and in vivo confocal microscopy were examined. RESULTS: At postoperative 2 years, 2 eyes (14.3%) gained one line of CDVA, 11 eyes (78.6%) had unchanged CDVA, and 1 eye (7.1%) lost one line of CDVA. No eyes lost two or more lines of CDVA. Twelve of the treated eyes (85.7%) had postoperative uncorrected near visual acuity equal to or better than pre-operative values. The spherical equivalent decreased from +5.53 ± 1.45 D preoperatively to −0.60 ± 1.20 D at postoperative year 2 ( P < .001). The anterior mean keratometric readings increased from 42.41 ± 1.03 D preoperatively to 48.38 ± 1.98 D at postoperative year 2 ( P < .001). Of 14 treated eyes, 10 eyes (71.4%) had spherical equivalent within ±1.00 D. CONCLUSIONS: The findings suggest that allogenic lenticule transplantation may be a promising option for the correction of moderate to high hyperopia. [ J Refract Surg . 2021;37(11):734–740.]

Late recurrence of corneal dystrophy treated with phototherapeutic keratectomy combined with epikeratophakia using double lenticules

“…Although future studies with larger sample sizes and longer follow-up are needed, because of the high precision of the SMILE-derived lenticule and its excellent biocompatibility, it is reasonable to assume that the EP lenticules derived from SMILE will remain transparent for a long time. 14…”

“…Although future studies with larger sample sizes and longer follow-up are needed, because of the high precision of the SMILE-derived lenticule and its excellent biocompatibility, it is reasonable to assume that the EP lenticules derived from SMILE will remain transparent for a long time. 14 Dinh et al showed that 47% of patients with RBCD who received PTK experience significant recurrence after 21.6 months on average. 15 A study by Hieda et al reported no significant differences in recurrence rates between first PTK treatment and repeated PTK in patients with variant types of corneal dystrophy.…”

Comparison of Visual Outcomes and Higher-order Aberrations Between FS-LASIK and SMI-LIKE for Moderate to High Hyperopia: A 2-Year Result

“…5,6 LIKE is a newly emerged procedure for the correction of hyperopia. [7][8][9][10][11][12] It has showed acceptable safety, efficacy, and predictability in the correction of moderate and high hyperopia. 8,11 However, no study has compared the long-term visual outcomes of LASIK and LIKE.…”

“…[7][8][9][10][11][12] It has showed acceptable safety, efficacy, and predictability in the correction of moderate and high hyperopia. 8,11 However, no study has compared the long-term visual outcomes of LASIK and LIKE. In this study, we evaluated the visual outcomes and higher-order aberrations (HOAs) 2 years after femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small-incision lenticule intrastromal keratoplasty (SMI-LIKE) in the correction of moderate to high hyperopia.…”

Lenticule Intrastromal Keratoplasty for the Correction of Iatrogenic High Hyperopia

“…2 Lenticule intrastromal keratoplasty (LIKE) has recently emerged as a refractive surgical technique. [3][4][5][6][7] Using the lenticule derived during SMILE for the correction of myopia, the cornea is thickened and the curvature of the anterior corneal surface is increased. Because of its good safety and efficacy, LIKE has been adopted for the treatment of various diseases, such as hyperopia, keratoconus, and presbyopia.…”