Visual Manifestations of Visible and Buried Optic Disc Drusen

Wilkins, Jay M.; Pomeranz, Howard D.

doi:10.1097/00041327-200406000-00006

Cited by 124 publications

(97 citation statements)

References 14 publications

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“…These findings are similar to other previously published studies that identified that visual field is often affected when exposed ODD are present. 7,10,24,25 However, it is against our expected hypothesis that eyes with ED without a history of papilloedema had 3.86 dB worse Humphrey visual field (HVF) mean MD compared with rPAP-ED (−9.88 vs. −6.02 dB), as we originally thought the combination of both conditions (cODD-rPAP) might lead to a worse visual outcome than either condition alone.…”

Section: Discussionmentioning

confidence: 87%

“…ODD by themselves are associated with visual field deficits in 70% of affected individuals. 10,24,25 ODD tend to evolve over time from being buried to becoming exposed in the setting of optic atrophy and reduction of the retinal nerve fibre layer (RNFL) thickness. 25 Worse visual field deficits are associated with exposed drusen as compared with buried drusen.…”

Section: Introductionmentioning

confidence: 99%

“…25 Worse visual field deficits are associated with exposed drusen as compared with buried drusen. 24,25 Vision loss from IIH, most commonly an enlarged blind spot, occurs in 50-90% of patients, and approximately 10-25% may have permanent vision loss. [26][27][28] It is unknown if the visual acuity and visual field outcomes of eyes harbouring both conditions, ODD and papilloedema, are different from eyes with either condition alone.…”

Section: Introductionmentioning

confidence: 99%

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Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Birnbaum

Johnson

et al. 2016

Neuro-Ophthalmology

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This is a 25-year observational retrospective review of 372 consecutive participants with optic disc drusen or resolved papilloedema from idiopathic intracranial hypertension. The prevalence of optic disc drusen at 19% among eyes with resolved papilloedema was approximately 10 times higher and significantly increased (p < 0.001) as compared with the occurrence in the general population. Eyes with both resolved papilloedema and optic disc drusen had similar visual acuity and visual field outcome as compared with resolved papilloedema alone. Eyes with exposed drusen had significantly worse visual acuity and visual field outcome (p < 0.001) than buried drusen. The high prevalence of optic disc drusen after papilloedema has resolved suggests a non-coincidental relationship. Optic disc drusen formation can be a sequela of papilloedema.ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Birnbaum

Johnson

et al. 2016

Neuro-Ophthalmology

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“…Though patients with buried optic disc drusen have not been well characterised, a review of patients with the condition suggests that clinical symptoms correlate to visibility of the drusen [16]. Concerns of deteriorating vision in the child prompted serial assessments until the time when drusen was visibly confirmed.…”

Section: Discussionmentioning

confidence: 99%

Optic Disc Drusen in a Child Diagnosed with Alport Syndrome—Case Report

Sambo¹,

Aslam²,

Padmanabha³

2014

OJNeph

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Optic disc drusen are eye abnormalities characterised by calcific degeneration affecting some axons of the optic nerve. Alport syndrome is a collagen IV related nephropathy with well-described pathognomonic ocular features. We present the case of a child who following series of investigations was found to have bilateral optic disc drusen, and eventually a further diagnosis of Alport syndrome confirmed. Literature is clear on the underlined aetiology responsible for both renal and extra renal abnormalities of Alport syndrome, which is not related to development of optic disc drusen. The case described makes it pertinent that not only the associated eye signs of Alport syndrome are monitored, but also early detection of other possible co-existing diseases that may influence outcomes.

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“…This difference may be due to the fact that the drusen visible with oblique illumination identified by Mustonen [20] were probably hidden but shallow drusen, which we categorized as hidden drusen. Wilkins and Pomeranz [22] reported 42% of visible ODD (33/79 ODD). The evolution of ODD has proved to be a dynamic process, which begins as deep or hidden drusen in childhood and later on, from the second decade of life, become more superficial [1,8,23].…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Features of Optic Disc Drusen

2012

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Purpose: To evaluate the ophthalmoscopic manifestations of patients with visible and hidden optic disc drusen (ODD). Method: We studied 55 patients (100 eyes) with ODD that were confirmed using B-scan ultrasonography and a control group of 60 patients (100 eyes) for differential diagnosis. We analysed the optic nerve features with stereoscopic photography and compared the characteristics between visible and hidden ODD and between hidden ODD and papilloedema. Results: The patients with ODD presented the following ophthalmoscopic features: visible drusen (52%), blurred edges (84%), raised optic disc (74%), absence of optic disc cupping (69%), absence of venous pulse (54%), abnormal vascular branching (81%), presence of cilioretinal vessels (42%), peripapillary atrophy (56%) and haemorrhages (2%). Comparison of the qualitative characteristics of the papillae of the eyes with visible and hidden ODD showed statistically significant differences in all parameters studied, except for morphological alterations (p = 0.851) and haemorrhage (p = 0.954). Comparison of hidden ODD with papilloedema showed statistically significant differences in blurred edges, disc elevation, absence of optic disc cupping, altered colour, anomalous vascular branching and optic disc haemorrhages (p < 0.005). Conclusions: Ophthalmologic features associated with ODD can help us to diagnose their presence and avoid confusing them with papilloedema.

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Visual Manifestations of Visible and Buried Optic Disc Drusen

Cited by 124 publications

References 14 publications

Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Optic Disc Drusen in a Child Diagnosed with Alport Syndrome—Case Report

Ophthalmic Features of Optic Disc Drusen

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