Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Birnbaum, Faith A.; Johnson, Gabriella M.; Johnson, Lenworth N.; Jun, Bokkwan; Machan, Jason T.

doi:10.1080/01658107.2016.1198917

Cited by 21 publications

(19 citation statements)

References 31 publications

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“…To date, there is no substantial evidence that the hyperreflective mass-like structures, almost always located in the peripapillary circumference, and described and visualized in several papers, in fact represent ODD. A study by Birnbaum et al (2016) found an extraordinarily high ODD prevalence (19%) in patients with idiopathic intracranial hypertension. A study by Birnbaum et al (2016) found an extraordinarily high ODD prevalence (19%) in patients with idiopathic intracranial hypertension.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 98%

“…It is more likely that these structures represent disruption of retinal layers caused by local axoplasmic build-up, as they are also found in patients with idiopathic intracranial hypertension (Malmqvist et al 2017a) and optic nerve tumours (Lee et al 2015). A study by Birnbaum et al (2016) found an extraordinarily high ODD prevalence (19%) in patients with idiopathic intracranial hypertension. The high number of ODD patients in the group is most likely a result of misdiagnosing hyperreflective masslike structures as ODD and not as a disruption of retinal layers.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

“…The differentiation between ODD and papilloedema has been investigated in numerous reports (Johnson et al 2009;Lee et al 2011;Sarac et al 2012;Bassi & Mohana 2014;Kulkarni et al 2014;Birnbaum et al 2016). A 'lazy V' pattern or 'lumpy bumpy' internal contour of the subretinal hyporeflective space (Johnson et al 2009;Sarac et al 2012) and decreased RNFL thickness (Johnson et al 2009;Lee et al 2011;Sarac et al 2012;Bassi & Mohana 2014) have been used to differentiate ODD from papilloedema using OCT.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

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Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

101

106

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Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur. There are no treatments available to prevent or ameliorate the vision loss caused by ODD. In children, the ODD are usually uncalcified and buried within the optic nerve head tissue. In these cases, the condition can be difficult to diagnose, as it often resembles a papilloedema with optic nerve head swelling caused by raised intracranial pressure. During the teenage years, the ODD progressively become more calcified and probably also larger, which allow them to be visible on ophthalmoscopy. With the advent and proper utilization of high-resolution modalities of optical coherence tomography (OCT), it has now become possible to detect even the smallest and most deeply located ODD. This allows for ODD detection at a much earlier developmental stage than has previously been possible and enhances the possibilities of research in underlying mechanisms. A review of the literature on ODD was conducted using the PUBMED database. The review focuses on the current knowledge regarding pathogenesis, diagnostics, clinical disease-tracking methodologies, structure-function relationships and treatment strategies of ODD.

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Section: Optical Coherence Tomography (Oct)mentioning

confidence: 98%

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

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Optic disc drusen: understanding an old problem from a new perspective

Hamann

Malmqvist

Costello

2018

Acta Ophthalmologica

101

106

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“…PTS'li hastalarda ODD prevalansının normal popülasyondan daha yüksek oranda görüldüğü, hatta uzun süren papil ödem sonrası ODD oluştuğu düşünülmektedir. 15 Bu birliktelik çalışmamızda %7,4 idi. Bu bulgular ışığında, ODD tanısı alan hastalarda gerçek papil ödem birlikteliği de düşünülmeli, periyodik takip ve tetkik yapılmalıdır.…”

Section: Discussionunclassified

Demographic, Clinical and Treatment Findings of Pseudotumor Cerebri Syndrome

Orman¹,

Sungur²,

Uzman³

et al. 2020

Turkiye Klinikleri J Ophthalmol

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Beyin omurilik sıvısı bileşiminin normal olması ve intrakraniyal yer kaplayıcı lezyon veya hidrosefali gibi yapısal bir lezyonun olmaması ile ortaya çıkan kafa içi basıncının artışı, psödotümör serebri sendromu (PTS) olarak kabul edilmektedir. Bu çalışmada, PTS tanısı ile izlenen hastaların klinik, nörooftalmolojik ve demografik özelliklerinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Ankara Eğitim ve Araştırma Hastanesi Göz Kliniği Nörooftalmoloji Biriminde, Haziran 2016-Haziran 2018 tarihleri arasında başvuran PTS tanılı hastalar retrospektif olarak incelendi. Hastaların tüm nörooftalmolojik muayeneleri, bilgisayarlı görme alanı, optik koherens tomografi ve magnetik rezonans görüntüleme (MRG) bulguları değerlendirildi. Bulgular: PTS tanısı almış 54 hastanın 108 gözü incelendi. Hastaların 48 (%88,9)'si kadın, 6 (%11,1)'sı erkekti. Ortalama yaş 32,5 ± 11,6 yıl idi. Baş ağrısı ile 31 (%57,4), geçici görme kaybı ile 10 (%18,5), rutin göz muayenesi sırasında 9 (%16,7), çift görme ile 3 (%5,6), kulak uğultusu ile 1 (%1,9) hasta başvurmuştu. Yeni tanı almış 24 hastanın 21 (87,5)'inde papil ödem saptandı, 3 (%12,5)'ünde papil ödem yoktu. Hastaların tümüne bakıldığında; 4 (%7,4)'ünde optik disk druseni (ODD) ile birlikte papil ödem, 1'inde iki gözün 6 yıl ara ile etkilendiği tespit edildi. Hastaların tümüne medikal tedavi uygulandı. Olguların 49 (%90,7)'u asetazolamidden yarar gördü. Medikal tedaviye yanıt vermeyen 5 (%9,3) hastaya cerrahi planlandı. Hastaların 4 (%7,4)'üne ventriküloperitoneal şant, 1 (%1,9)'ine optik sinir kılıf fenestrasyonu uygulandı. Sonuç: Çalışmamızda; PTS'li hastaların yarısında oftalmolojik semptomlar ile tanıya gidildiği tespit edilmiştir. Bu nedenle rutin oftalmolojik muayenede fundus değerlendirilmesi önemlidir. Bu çalışmada, hastaların yaklaşık yarısında MRG'nin normal olabileceği, tek taraflı papil ödem, papil ödemsiz ve ODD ile papil ödem hastalarının görülebileceğini vurgulamak istedik. Bu klinik bulgular tespit edilen hastalarda ön tanıda PTS akılda tutulmalıdır. Uygun ve zamanında tanı ve tedavi ile görme kayıplarının önüne geçilebilir. Anah tar Ke li me ler: Psödotümör serebri; demografi; papil ödem ABS TRACT Objective: Pseudotumor cerebri syndrome (PTCS) is increased intracranial pressure with normal cerebrospinal fluid composition and absence of a structural lesion such as intracranial space-occupying lesion or hydrocephalus. This study aimed to investigate the clinical and demographic characteristics of patients with PTCS. Material and Methods: A retrospective analysis of PTCS was performed between June 2016-June 2018 in the Neuro-Ophthalmology Unit of Ankara Training and Research Hospital Eye Clinic. All ophthalmologic examinations, visual field, optical coherence tomography (OCT) and magnetic resonance (MR) findings were evaluated. Results:108 eyes of 54 PTCS patients were assesmented. 48 (88.9%) patients were female and 6 (11.1%) patients were male. The mean age was 32.5 ± 11.6. 31 (57.4%) patients had headache, 10 (18.5%) had transient vision problem, 9 (16.7%) had in rout...

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“…116 Reviewing 372 patients with ONHD or resolved papilloedema from IIH, others found 19% of resolved papilloedema eyes to have ONHD but this was also based on outdated OCT definitions and uncertain diagnostic criteria. 117 Acquired ONHD is not widely recognised as a common outcome after papilloedema. It may simply be that neurological patients with headaches have their optic discs examined closely, and that ONHD may be detected more often in this broad group.…”

Section: Papilloedemamentioning

confidence: 99%

Optic Nerve Head Drusen: An Update

Palmer

Gale

Crowston

et al. 2018

Neuro-Ophthalmology

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Optic nerve head drusen are benign acellular calcium concretions that usually form early in life, just anterior to the lamina cribrosa. Improving imaging using optical coherence tomography suggests they are common and may be present in many clinically normal discs. These drusen may change in appearance in early life, but are generally stable in adulthood, and may be associated with visual field defects, anterior ischaemic optic neuropathy, or rarer complications. Based on long-term clinical data and optical coherence tomography, we propose a refined hypothesis as to the cause of optic disc drusen. Here we summarise recent findings and suggest future studies to better understand the forces involved.

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Increased Prevalence of Optic Disc Drusen after Papilloedema from Idiopathic Intracranial Hypertension: On the Possible Formation of Optic Disc Drusen

Cited by 21 publications

References 31 publications

Optic disc drusen: understanding an old problem from a new perspective

Optic disc drusen: understanding an old problem from a new perspective

Demographic, Clinical and Treatment Findings of Pseudotumor Cerebri Syndrome

Optic Nerve Head Drusen: An Update

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