Visual function in the brain-damaged child

Hoyt, Creig S.

doi:10.1038/sj.eye.6700364

Cited by 150 publications

(176 citation statements)

References 159 publications

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“…8 The natural history of this patient seems to confirm early acquired striate lesion even though his visual recovery took longer than expected.…”

Section: Discussionmentioning

confidence: 55%

“…6,7 The effects of early-acquired visual cortical lesions have been less extensively studied. [8][9][10] This is probably because in childhood, early-acquired lesions of the visual system are usually associated with extensive involvement of the retrochiasmatic visual pathways, leading to the wide spectrum of visual dysfunctions known as cerebral visual impairment (CVI), 11,12 whereas select ive injuries of the striate cortex are rare.…”

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confidence: 99%

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Recovery of visual functions after early acquired occipital damage

Bova

Giovenzana

Signorini

et al. 2008

Develop Med Child Neuro

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Plasticity of visual systems after early brain damage has been extensively studied in animal models but poorly documented in children after visual pathway lesions. This report describes the visual recovery of a male child who had a bilateral occipital lobe infarction at the age of 2 years 6 months, 10 days after colon resection for Hirschsprung disease. In the acute phase he had severe visual impairment without visual response. Some weeks later he could perceive movement. Since then, progressive recovery of his visual acuity and oculomotor abilities has been accompanied by a progressive reduction of the visual field defect. At 6 years 8 months, visual recognition acuity was 10/10 in both eyes and neuro‐ophthalmological examination was normal, except for persistence of the visual field defect in the upper hemifield and a selective impairment of higher visual functions (recognition of object presented in a hard‐to‐decode way [e.g. overlapping figures], or use of complex visuospatial skills). The functional recovery observed in this patient confirms the adaptive plasticity of developing visual systems after early brain lesions. It suggests that in humans, as in animal models, processes related to cerebral plasticity may take place years after a brain lesion has been sustained.

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“…8 The natural history of this patient seems to confirm early acquired striate lesion even though his visual recovery took longer than expected.…”

Section: Discussionmentioning

confidence: 55%

mentioning

confidence: 99%

Recovery of visual functions after early acquired occipital damage

Bova

Giovenzana

Signorini

et al. 2008

Develop Med Child Neuro

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show abstract

“…'lar› (25) Hipoksik iskemik beyin hasar›, kortikal görsel bozukluklar›n önemli nedenlerinden biridir (26). Görsel uyar›lma potansiyelleri, görsel yollar ve oksipital korteksteki ifllevsel bozukluklar› yüksek zamansal çözünürlükle ve nesnel olarak yans›tan EEG temelli elektrofizyolojik bir tan› yöntemidir (19).…”

Section: Tart›flmaunclassified

Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT-491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri

Atıcı¹

2010

tpa

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H Hi ip po ok ks si ik k i is sk ke em mi ik k b be ey yi in n h ha as sa ar r› › o ol lu ufl flt tu ur ru ul la an n y ye en ni id do o¤ ¤a an n s s› ›ç ça an nl la ar rd da a A AB BT T--4 49 91 1 u uy yg gu ul la am ma as s› ›n n› ›n n g gö ör rs se el l u uy ya ar r› ›l lm ma a p po ot ta an ns si iy ye el ll le er ri i ü üz ze er ri in ne e e et tk ki il le er ri i T Th he e e ef ff fe ec ct ts s o of f A AB BT T--4 49 91 1 a ad dm mi in ni is st tr ra at ti io on n o on n v vi is su ua al l e ev vo ok ke ed d p po ot te en nt ti ia al ls s i in n r ra at t m mo od de el l o of f h hy yp po ox xi ic c i is sc ch he em mi ic c b br ra ai in n i in nj ju ur ry y S Su um mm ma ar ry yAim: In the present study, we aimed to investigate the effects of ABT-491 on visual evoked potentials (VEP) in rat model of hypoxic ischemic brain injury (HIBI). Material and Method:Fifty-seven male Wistar newborn rats were used in this study. Animals were divided into three groups randomly. HIBI was formed on postnatal seventh day according to modified Levine-Rice model in 1st (n=18) and 2nd (n=20) groups. Third group (n=19) served as sham group. After HIBI, ABT-491 was applied intraperitoneally to rats in the 1st group (ABT group) and saline was administered to the rats in the 2nd group (saline group). On postnatal 16th weeks, VEPs were recorded from Ag-AgCl disc electrode placed on the occipital region. Results:The latencies of P3 wave were shorter in the ABT group than the saline group (p<0.05). Peak-to-peak amplitudes of P2-N2 and N2-P3 were smaller in the ABT and saline groups compared to the sham group (for all pairwise comparisons p<0.001).Conclusions:It was concluded that HIBI caused a decrement in amplitudes of VEP responses and this change could not be ameliorated with ABT-491. However, shortening in latencies of P3 wave could be ameliorated with ABT-491 treatment after HIBI was formed. (Turk Arch Ped 2010; 45: 319-23)

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Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] In some centres, it exceeds all causes of childhood ocular blindness combined. 5 Historically, a wide range of aetiologies accounted for visual impairment associated with brain injury in children. These included hypoglycemia, 6 haemodialysis, 7 hydrocephalus, [8][9][10] trauma [11][12][13] (accidental but much more commonly and tragically non-accidental), seizures, 14 neurodegenerative disorders, 15 encephalitis/meningitis, [16][17][18][19][20] and other infectious disorders.…”

Section: Introductionmentioning

confidence: 99%

Brain injury and the eye

Hoyt

2007

Eye

Self Cite

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Visual loss associated with brain damage is the single greatest cause of visual impairment in children in developed countries. Damage may occur in any of five separate visual systems: primary visual cortex, visual associative cortex area, optic radiations, optic nerves, and visual attention pathways. Improving our understanding of the pathophysiology of these causes for visual loss may lead to better rehabilitation and educational strategies for these children.

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Visual function in the brain-damaged child

Abstract: The essential role of the primary visual cortex in visual processing has been extensively studied over the last century or more.

Cited by 150 publications

References 159 publications

Recovery of visual functions after early acquired occipital damage

Recovery of visual functions after early acquired occipital damage

Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT-491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri

Brain injury and the eye

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