Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT-491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri

Abstract

H Hi ip po ok ks si ik k i is sk ke em mi ik k b be ey yi in n h ha as sa ar r› › o ol lu ufl flt tu ur ru ul la an n y ye en ni id do o¤ ¤a an n s s› ›ç ça an nl la ar rd da a A AB BT T--4 49 91 1 u uy yg gu ul la am ma as s› ›n n› ›n n g gö ör rs se el l u uy ya ar r› ›l lm ma a p po ot ta an ns si iy ye el ll le er ri i ü üz ze er ri in ne e e et tk ki il le er ri i T Th he e e ef ff fe ec ct ts s o of f A AB BT T--4 49 91 1 a ad dm mi in ni is st tr ra at ti io on n o on n v vi is su ua al l e ev vo ok ke ed d p po ot te en nt ti ia al ls s i in n r ra at t m mo od de el l o of f h hy yp po ox xi ic c i is sc ch he em mi ic c b br ra ai in n i in nj ju ur ry y S Su um mm ma ar ry yAim: In the present study, we aimed to investigate the effects of ABT-491 on visual evoked potentials (VEP) in rat model of hypoxic ischemic brain injury (HIBI). Material and Method:Fifty-seven male Wistar newborn rats were used in this study. Animals were divided into three groups randomly. HIBI was formed on postnatal seventh day according to modified Levine-Rice model in 1st (n=18) and 2nd (n=20) groups. Third group (n=19) served as sham group. After HIBI, ABT-491 was applied intraperitoneally to rats in the 1st group (ABT group) and saline was administered to the rats in the 2nd group (saline group). On postnatal 16th weeks, VEPs were recorded from Ag-AgCl disc electrode placed on the occipital region. Results:The latencies of P3 wave were shorter in the ABT group than the saline group (p<0.05). Peak-to-peak amplitudes of P2-N2 and N2-P3 were smaller in the ABT and saline groups compared to the sham group (for all pairwise comparisons p<0.001).Conclusions:It was concluded that HIBI caused a decrement in amplitudes of VEP responses and this change could not be ameliorated with ABT-491. However, shortening in latencies of P3 wave could be ameliorated with ABT-491 treatment after HIBI was formed. (Turk Arch Ped 2010; 45: 319-23)