Visual Field Defects and Retinal Ganglion Cell Losses in Patients With Glaucoma

Harwerth, Ronald S.; Quigley, Harry A.

doi:10.1001/archopht.124.6.853

Cited by 194 publications

(133 citation statements)

References 24 publications

(8 reference statements)

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“…Eye diseases, such as age-related macular degeneration (AMD), 1 retinitis pigmentosa (RP), 2 diabetic retinopathy, 3,4 and glaucoma 5,6 can produce retinal neural dysfunctions that lead to severe vision loss if appropriate interventions are not involved promptly. It is known that different eye diseases damage different retinal cells, which are located in different functional layers.…”

Section: Introductionmentioning

confidence: 99%

In vivooptical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

Wang

Yao

2016

J. Biomed. Opt

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Abstract. Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical coherence tomography (SD-OCT) was employed for depth-resolved retinal imaging. A custom-designed animal holder equipped with ear bar and bite bar was used to minimize eye movements. Dynamic OCT imaging revealed rapid IOS from the photoreceptor's outer segment immediately after the stimulation delivery, and slow IOS changes were observed from inner retinal layers.Comparative photoreceptor IOS and electroretinography recordings suggested that the fast photoreceptor IOS may be attributed to the early stage of phototransduction before the hyperpolarization of retinal photoreceptor.

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Section: Introductionmentioning

confidence: 99%

In vivooptical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

Wang

Yao

2016

J. Biomed. Opt

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“…POAG can affect several structures along the visual pathway before behavioral deficits are noticed. For example, by the time visual field defects are detected using perimetry, 50-60% of the ganglion cells may already be dead (Harwerth et al, 1999;Harwerth and Quigley, 2006). Structural changes in the retina and optic nerve head observed during ophthalmologic examination may also be detected before functional changes (Sommer et al, 1991;Johnson et al, 2003).…”

mentioning

confidence: 99%

Retinotopic organization of primary visual cortex in glaucoma: Comparing fMRI measurements of cortical function with visual field loss

Duncan¹,

Sample²,

Weinreb³

et al. 2007

Progress in Retinal and Eye Research

117

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Primary open angle glaucoma (POAG) is a progressive optic neuropathy characterized by retinal ganglion cell loss. Experimental primate glaucoma indicates neuronal degeneration of the lateral geniculate nucleus (LGN) and activity changes in the visual cortex (V1). Neuronal degeneration has also been shown in a post-mortem human study of the optic nerve, LGN and visual cortex. Functional magnetic resonance imaging (fMRI), a non-invasive means of inferring function-specific neuronal activity, provides an opportunity to evaluate glaucomatous changes in neuronal activity throughout the visual pathway in vivo.The purpose of this study is to demonstrate that the relationship between visual field loss in human POAG and the functional organization of V1 can be measured using novel fMRI analysis methods. Visual field defects were measured using standard automated perimetry (SAP). A retinotopic map of visual space was obtained for V1, and the retinotopy data was fit with a template. The template was used to project regions within the visual field onto a flattened representation of V1. Viewing through the glaucomatous vs. fellow eye was compared by alternately presenting each eye with a scotoma-mapping stimulus. The resulting blood oxygen level dependent (BOLD) fMRI response was compared to interocular differences in thresholds for corresponding regions of the visual field.The spatial pattern of activity observed in the flattened representation agreed with the pattern of visual field loss. Furthermore, the amplitude of the BOLD response was correlated on a pointwise basis with the difference in sensitivity thresholds between the glaucomatous and fellow eyes (r = 0.53, p < 0.0001).The BOLD signal in human V1 is altered for POAG patients in a manner consistent with the loss of visual function. FMRI of visual brain areas is a potential means for quantifying glaucomatous changes in neuronal activity. This should enhance our understanding of glaucoma, and could lead to new diagnostic techniques and therapies. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptProg Retin Eye Res. Author manuscript; available in PMC 2008 January 1. Published in final edited form as:Prog Retin Eye Res. 2007 January ; 26(1): 38-56. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript Glaucomatous neuronal degeneration in the central nervous systemGlaucoma is a group of progressive optic neuropathies that share a common feature, a gradual loss of retinal ganglion cells accompanied by a progressive degeneration of the optic nerve. Left untreated, glau...

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“…11 In histological studies, it is reported that ganglion cell density has close correlation with standard perimetric findings. 12 It is shown that GA and GCC are correlated. 13 In the most recent studies, it has been shown that RNFL and GCC analyses conducted by RTVue-100 SD-OCT device may be used in the diagnostic evaluation of glaucoma and OHT patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Central Macular Thickness and Perifoveal Ganglion Cell Complex Thickness with Optical Coherence Tomography in Cases with Primary Open Angle Glaucoma and Ocular Hypertension

Demir¹,

Sendul²,

Dirim³

et al. 2017

World Clin J Med Sci

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Visual Field Defects and Retinal Ganglion Cell Losses in Patients With Glaucoma

Cited by 194 publications

References 24 publications

In vivooptical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

In vivooptical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

Retinotopic organization of primary visual cortex in glaucoma: Comparing fMRI measurements of cortical function with visual field loss

Evaluation of Central Macular Thickness and Perifoveal Ganglion Cell Complex Thickness with Optical Coherence Tomography in Cases with Primary Open Angle Glaucoma and Ocular Hypertension

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