“…Although a duration of up to 4 weeks of intraocular tamponade with a long acting gas and prone positioning was initially believed to be essential for improved MH closure rate, 10 similar successful outcomes have been achieved with much shorter periods, ranging from 2 weeks or less, [10][11][12][13]32,33,53 to no postoperative positioning at all. 38,39,54 Moreover, PPP may play a role in the development of postoperative IOP elevation 55 and visual field defects, 56 as well as retinal pigment epithelial damage, 37 the most common sight threatening postoperative complication in the Vitrectomy for Macular Hole Study. 16 Furthermore, PPP may be associated with ventilatory disturbances in some patients by decreasing the minute ventilatory volumes and increasing transcutaneous carbon dioxide tensions.…”