Visual Distortion Provoked by a Stimulus in Migraine Associated With Hyperneuronal Activity

Huang, Jie; Cooper, Tim F.; Şatana, Banu; Kaufman, David I.; Cao, Yue

doi:10.1046/j.1526-4610.2003.03110.x

Cited by 147 publications

(178 citation statements)

References 20 publications

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“…They are stimuli that at high contrasts interfere with the visibility of small low contrast target stimuli, masking them effectively (Chronicle and Wilkins, 1996). The stimuli evoke high-amplitude electrical signals from the scalp (Plant et al, 1983) and large blood oxygenation dependent signals during functional magnetic resonance imaging (Huang et al, 2003). They induce perceptual distortions and, in those who are susceptible, migraine (Huang et al, 2003) and seizures (Wilkins et al, 1980).…”

Section: Strong Visual Stimulationmentioning

confidence: 99%

Visual stress, its treatment with spectral filters, and its relationship to visually induced motion sickness

Wilkins

Evans

2010

Applied Ergonomics

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a b s t r a c tWe review the concept of visual stress and its relation to neurological disease. Visual stress can occur from the observation of images with unnatural spatial structure and an excess of contrast energy at spatial frequencies to which the visual system is generally most sensitive. Visual stress can often be reduced using spectral filters, provided the colour is selected with precision to suit each individual. The use of such filters and their effects on reading speed are reviewed. The filters have been shown to benefit patients with a variety of neurological conditions other than reading difficulty, all associated with an increased risk of seizures.

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Section: Strong Visual Stimulationmentioning

confidence: 99%

Visual stress, its treatment with spectral filters, and its relationship to visually induced motion sickness

Wilkins

Evans

2010

Applied Ergonomics

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“…Aurora et al (1998Aurora et al ( , 1999 used transcranial magnetic stimulation to demonstrate that the visual cortex is indeed hyperexcitable in people who suffer from migraine. Huang et al (2003) used functional MRI in patients who had migraine with aura to show that square-wave gratings that produced pattern glare did induce a hyperneuronal response in the visual cortex.…”

Section: Pattern Glare Visual Stress and Headachementioning

confidence: 99%

The optometric correlates of migraine

Harle

Evans

2004

Ophthalmic Physiologic Optic

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Migraine is a common, chronic, multi-factorial, neuro-vascular disorder typically characterised by recurrent attacks of unilateral, pulsating headache and autonomic nervous system dysfunction. Migraine may additionally be associated with aura; those focal neurological symptoms that may precede or sometimes accompany the headache. This review describes the optometric aspects of migraine headache. There have been claims of a relationship between migraine headaches and errors of refraction, binocular vision anomalies, pupil anomalies, visual field changes and pattern glare. The quality of the evidence for a relationship between errors of refraction and binocular vision and migraine is poor. The quality of the evidence to suggest a relationship between migraine headache and pupil anomalies, visual field defects and pattern glare is stronger. In particular the link between migraine headache and pattern glare is striking. The therapeutic use of precision-tinted spectacles to reduce pattern glare (visual stress) and to help some migraine sufferers is described.

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“…Higher contrast grating patterns also increase the amplitude of visual evoked potentials and increase gamma activity in visual cortex (Schadow et al, 2007). However, there is some debate over the sensitivity of the haemodynamic response to changes in spatial frequency (compare Swettenham et al, 2013, with Huang et al, 2003. Tong et al (2005) measured NIRS and EEG responses to an auditory stimulus in an odd-ball paradigm, and found an increase in oxyhaemoglobin a few seconds after the presence of a P300 component in an ERP response.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Huang et al (2003) found that patients with migraine showed larger BOLD responses to grating stimuli than controls. It is therefore of interest that Coutts et al (2012) using NIRS found that patients with migraine showed shorter oxyhaemoglobin responses compared to healthy controls, suggesting that the shape of the haemodynamic response can also be related to cortical excitability.…”

Section: Introductionmentioning

confidence: 99%

Cortical excitability and the shape of the haemodynamic response

2015

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Individual differences in the temporal dynamics of the haemodynamic response can reflect cortical excitation and can reveal underlying cortical physiology. Here, we show differences in the shape of the haemodynamic response that are dependent on stimulus parameters. Two sets of visual stimuli were used varying in parameters that are known to manipulate the haemodynamic response in the visual cortex. We measured the oxyhaemoglobin response using near infrared spectroscopy. The first set of stimuli comprised chromatic square-wave gratings that varied with respect to the separation in the CIE UCS chromaticities of the alternating bars. The gratings with large separations in chromaticity evoked an oxyhaemoglobin response with greater amplitude, consistent with greater activation of the visual cortex. The second set of stimuli comprised horizontal achromatic gratings that (1) were static, (2) drifted at a constant velocity towards fixation, or (3) reversed direction every half spatial cycle to create a vertical vibrating motion. Although the three types of grating had a similar effect on the amplitude of the oxyhaemoglobin response, the moving gratings (2 and 3) evoked a steeper decrease in oxyhaemoglobin concentration after stimulus-offset. The steeper slope appears to reflect the poststimulus undershoot and the slope may provide a correlate of cortical excitability when the amplitude of the haemodynamic response has saturated.

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Visual Distortion Provoked by a Stimulus in Migraine Associated With Hyperneuronal Activity

Abstract: The hyperneuronal activity of the occipital cortex is consistent with general cortical hyperexcitability in migraine.

Cited by 147 publications

References 20 publications

Visual stress, its treatment with spectral filters, and its relationship to visually induced motion sickness

Visual stress, its treatment with spectral filters, and its relationship to visually induced motion sickness

The optometric correlates of migraine

Cortical excitability and the shape of the haemodynamic response

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