Visual assessment of medial temporal atrophy on MR films in Alzheimer’s disease: comparison with volumetry

Bresciani, Lorenzo; Rossi, Roberta; Testa, Cristina; Geroldi, Cristina; Galluzzi, Samantha; Laakso, Mikko P.; Beltramello, Alberto; Soininen, Hilkka; Frisoni, Giovanni B.

doi:10.1007/bf03337714

Cited by 71 publications

(58 citation statements)

References 11 publications

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“…Furthermore, the assessments of WMH and of MTA are based on visual rating. Although the rating scale used in the study has shown a good sensitivity in the detection of WMHs [27] , and MTL [51,30] , volumetric measurement of WMHs and medial temporal structures with quantitative advanced tools could be useful to confirm the present findings. Lastly, longitudinal data are available for a small fraction of patients.…”

Section: Discussionsupporting

confidence: 63%

Clinical and Neuropsychological Features Associated with Structural Imaging Patterns in Patients with Mild Cognitive Impairment

Rossi

Geroldi

Bresciani

et al. 2007

Dement Geriatr Cogn Disord

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Aim: To describe the clinical and neuropsychological features of mild cognitive impairment (MCI) patients with medial temporal atrophy (MTA), white matter hyperintensities (WMH), both, and neither and to assess whether the rate of progression differs among groups. Methods: Ninety-five MCI patients were divided into 4 groups based on the presence of MTA and WMH: 29 were MTA– WMH–, 11 MTA– WMH+, 23 MTA+ WMH–, and 32 MTA+ WMH+. MCI patients were compared with 30 normal subjects. MTA and WMH were assessed with MR-based visual rating scales. Subjects underwent an extensive clinical and neuropsychological investigation. Fifty-six underwent follow-up evaluation. Results: MTA– WMH– had relatively good neuropsychological performance, little vascular and physical comorbidity. MTA– WMH+ performed poorly only on executive neuropsychological tests. MTA+ WMH– patients had poor neuropsychological performances (mainly on memory tests), high physical and vascular comorbidity. MTA+ WMH+ were impaired in neuropsychological performances, had a high number of physical diseases and severe vascular comorbidity. On follow-up, 25% of MTA+ WMH– and 32% of MTA+ WMH+ and none in MTA– WMH– and in MTA– WMH+ converted to dementia (p = 0.05, log rank test). Conclusion: Structural neuroimaging can identify subgroups of MCI patients with specific clinical and neuropsychological features.

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Section: Discussionsupporting

confidence: 63%

Clinical and Neuropsychological Features Associated with Structural Imaging Patterns in Patients with Mild Cognitive Impairment

Rossi

Geroldi

Bresciani

et al. 2007

Dement Geriatr Cogn Disord

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“…Visual scales may not be as sensitive as structural volumetry, but they are cost-effective, usable in clinical practice, and have been proved to reach good reliability and correspondence to volumetric measurements. 38,39 In our evaluations, we separated subcortical and cortical atrophy, but were not able to evaluate specific cortical regions. Another disadvantage of the study is that brain atrophy was only evaluated at baseline and measures of progression were only available for lacunes and WML for a subgroup of the sample.…”

Section: Figure 2 Combined Effects Of White Matter Lesions (Wml) and mentioning

confidence: 99%

Brain atrophy accelerates cognitive decline in cerebral small vessel disease

Jokinen¹,

Lipsanen²,

Schmidt

et al. 2012

Neurology

131

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Objective: To examine the independent contributions and combined interactions of medial temporal lobe atrophy (MTA), cortical and subcortical atrophy, and white matter lesion (WML) volume in longitudinal cognitive performance. Methods:A total of 477 subjects with age-related WML were evaluated with brain MRI and annual neuropsychological examinations in 3-year follow-up. Baseline MRI determinants of cognitive decline were analyzed with linear mixed models controlling for multiple confounders.Results: MTA and subcortical atrophy predicted significantly steeper rate of decline in global cognitive measures as well as compound scores for psychomotor speed, executive functions, and memory after adjusting for age, gender, education, lacunes/infarcts, and WML volume. Cortical atrophy independently predicted decline in psychomotor speed. WML volume remained significantly associated with cognitive decline even after controlling for the atrophy scores. Moreover, significant synergistic interactions were found between WML and atrophy measures in overall cognitive performance across time and the rate of cognitive decline. Synergistic effects were also observed between baseline lacunar infarcts and all atrophy measures on change in psychomotor speed. The main results remained robust after exclusion of subjects with clinical stroke or incident dementia, and after additional adjustments for progression of WML and lacunes.Conclusions: Brain atrophy and WML are independently related to longitudinal cognitive decline in small vessel disease. MTA, subcortical, and cortical atrophy seem to potentiate the effect of WML and lacunes on cognitive decline. Neurology ® 2012;78:1785-1792

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“…Visual rating such as medial temporal atrophy ratings scales [31] has been shown to distinguish clinically diagnosed AD patients from controls with a sensitivity of approximately 85% for a specificity of 80% [32]. Width of temporal lobe on MRI has been shown to have a sensitivity of 86% and a specificity of 93% when discriminating AD subjects from controls [33].…”

Section: Discussionmentioning

confidence: 99%

Does registration of serial MRI improve diagnosis of dementia?

et al. 2010

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Introduction We aimed to assess the value of a second MR scan in the radiological diagnosis of dementia. Methods One hundred twenty subjects with clinical followup of at least 1 year with two scans were selected from a cognitive disorders clinic. Scans were reviewed as a single first scan (method A), two unregistered scans presented sideby-side (method B) and a registered pair (method C). Scans were presented to two neuroradiologists and a clinician together with approximate scan interval (if applicable) and age. Raters decided on a main and subtype diagnosis. Results There was no evidence that differences between methods (expressed as relative odds of a correct response) differed between reviewers (p = 0.17 for degenerative condition or not, p=0.5 for main diagnosis, p=0.16 for subtype). Accordingly, results were pooled over reviewers.For distinguishing normal/non-progressors from degenerative conditions, the proportions correctly diagnosed were higher with methods B and C than with A (p=0.001, both tests). The difference between method B and C was not statistically significant (p=0.18). For main diagnosis, the proportion of correct diagnoses were highest with method C for all three reviewers; however, this was not statistically significant comparing with method A (p=0.23) or with method B (p=0.16). For subtype diagnosis, there was some evidence that method C was better than method A (p=0.01) and B (p=0.048).Conclusions Serial MRI and registration may improve visual diagnosis in dementia.

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Visual assessment of medial temporal atrophy on MR films in Alzheimer’s disease: comparison with volumetry

Abstract: The visual rating scale of MTA, easily applicable in clinical practice, shows good agreement with more demanding quantitative methods, and can discriminate AD patients from controls with good accuracy.

Cited by 71 publications

References 11 publications

Clinical and Neuropsychological Features Associated with Structural Imaging Patterns in Patients with Mild Cognitive Impairment

Clinical and Neuropsychological Features Associated with Structural Imaging Patterns in Patients with Mild Cognitive Impairment

Brain atrophy accelerates cognitive decline in cerebral small vessel disease

Does registration of serial MRI improve diagnosis of dementia?

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