“…Although higher-order aberrations (HOAs) make a small contribution (r10%) to the overall wave aberration in the eye, 71 some authors have shown a large effect of degradation in the quality of the retinal image and affect visual acuity. 72 There are factors that may contribute to the change in aberrations, such as ageing, [73][74][75][76][77] accommodation, 78 photoreceptors, 73 pupil size, 71,[79][80][81][82] refractive surgery, 76,[83][84][85] and tear film. 86,87 Even though there are no studies evaluating the impact that these factors could have on HOAs in people with DM, these do have a thicker and more convex lens, [54][55][56] can develop premature cataracts, [9][10][11] and suffer a series of changes associated with lachrymal gland dysfunction and dry eye syndrome.…”