This paper presents a case study about the development of a cross-disciplinary propose for preprimary, primary and secondary private school textbooks and course materials based on a Judeo-Christian educational worldview. A private Brazilian system of education, Sistema Mackenzie de Ensino (SME), located in São Paulo-Brazil, developed this proposal. SME is reasoned in a worldview, which considers ontology precedes epistemology to try to reach a more integrated perception, comprehension, and reflection of the study object. A crossdisciplinary team of teachers gathered to elaborate a critical basis for producing and reviewing the textbooks and course materials. This rational basis considered the guidelines of the National Brazilian Curriculum Parameters and academic researches. Sistema Mackenzie de Ensino has already published around 700 school textbooks and course materials (student and teacher textbooks, teacher manuals, workbooks) since 2009, and is currently used in about 350 schools, 70,000 students, in 21 out of 24 Brazilian States. As an example, this case study will show the production of a chapter of the Chemistry textbook for 2nd year of Upper secondary level of education, which deals with electrochemical contents, arguing about why ontology preceding epistemology provides a more integrated perception, comprehension, and reflection of the study of Chemistry.