Visible Spectrophotometric Analysis Method of Sodium Metamizole in Tablets

Abstract

The aim of this research was to exactly quantify pure sodium metamizole from tablets , using a spectrophotometric analysis in Visible range. The method applied has been subjected to a validation protocal which consisted in analyzing the following parameters: linearity of the method, detection limit (LD) , quantitation limit (LQ), Sandell�s sensitivity, interference of excipients, stability of prepared solutions, method and system precision, accuracy of the method. Following actual dosing, pure sodium metamizole amount in tablet of pharmaceutical was found to be 477.477 mg assigned to a percentage content of 95.495 %, very close to official declared amount (500 mg), with an maximum average percentage deviation of only 4.505 % from the official declared active substance content. This value was situated below the maximum admissible percentage deviation from stated active substance content (� 5%), established by Romanian Pharmacopoeia, X-th Edition rules.

Non-covalent binding and selective fluorescent sensing of dipyrone with a carbocyanine dye and cetyltrimethylammonium bromide

“…Therefore, interest to analytical methods for Dip (table S1 is available online at stacks.iop.org/MAF/ 9/015001/mmedia) has been maintained during the recent years [24,[33][34][35]46]. Dip was determined by electrochemical [18][19][20][21][22][23][24], chromatographic [25][26][27][28][29][30]47] and spectroscopic [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] methods.…”

“…Therefore, interest to analytical methods for Dip (table S1 is available online at stacks.iop.org/MAF/ 9/015001/mmedia) has been maintained during the recent years [24,[33][34][35]46]. Dip was determined by electrochemical [18][19][20][21][22][23][24], chromatographic [25][26][27][28][29][30]47] and spectroscopic [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] methods. A number of tests for Dip in single or multi-component pharmaceutical formulations have been developed using intrinsic UV absorption [31][32][33][34][35] or reactions with chemiluminescent [36][37][38], fluorescent [39], and spectrophotometric detection [40][41][42]…”

“…Dip was determined by electrochemical [18][19][20][21][22][23][24], chromatographic [25][26][27][28][29][30]47] and spectroscopic [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] methods. A number of tests for Dip in single or multi-component pharmaceutical formulations have been developed using intrinsic UV absorption [31][32][33][34][35] or reactions with chemiluminescent [36][37][38], fluorescent [39], and spectrophotometric detection [40][41][42][43][44][45][46]. An immunochromatorgaphic test is offered for the determination of Dip and its metabolites in dairy products [47].…”

“…An immunochromatorgaphic test is offered for the determination of Dip and its metabolites in dairy products [47]. It would be desirable to develop a spectral test for dipyrone not requiring biomolecules [47] or heating with sulfuric acid [36,37,39,41,42,46]. If such a method is based on a NIR dye, it would avoid the short-wave background fluorescence of biological samples.…”