Visible-light-induced oxidant/additive-free atom-economic synthesis of multifunctionalized cyclopropanes via energy transfer

Abstract

Herein we describe intramolecular cascade reactions enabling the synthesis of bridged cyclopropanes, via the photoinduced energy-transfer catalysis of tethered conjugated dienes.

Visible light-driven highly atom-economical divergent synthesis of substituted fluorenols and cyclopropylcarbaldehydes

“…13 c However, the abovementioned methods often suffer from harsh reaction conditions, environmentally unfriendly protocols, a mixture of regioisomers or a limited substrate scope, very low atom economy, and the generation of by-products. To address these challenges, our and other research groups rationally designed several protocols for enyne precursors bearing different groups, 14,15 which are more readily accessible than the acyclic substrates required in conventional methods. Notably, achieving sequential introduction of two most valuable functionalities in a single cascade reaction in one step while enhancing molecular complexity using simple and easily accessible feedstocks, ideally with 100% atom economy, under mild conditions that ensure user-friendly operation represents a highly desirable yet challenging task in synthetic chemistry.…”