Visible light induced antibacterial properties of a Ru(II)–Pt(II) bimetallic complex

Ruthenium‐based Photoactive Metalloantibiotics†

“…The Ru(II)Pt(II) bimetallic complexes, consisting of a cis ‐PtCl 2 unit coupled to a ruthenium (II)‐based chromophore, display multiple binding modes with DNA (67). The photodynamic antibacterial properties of Ru(II)Pt(II) bimetallic complexes were first reported by Brewer and coworkers (68). The bimetallic complex, [Ru(Ph 2 phen) 2 (dpp)PtCl 2 ] 2+ (Ph 2 phen = 4,7‐diphenyl‐1,10‐phenanthroline and dpp = 2,3‐bis(2‐pyridyl)pyrazine), displays bactericidal properties upon photoactivation ( λ irr = 520 nm, average total flux = 4.18 × 10 17 photons s −1 ).…”

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer’s structure and delivery systems

“…15) with phenanthroline, which was then tested against E. coli under white light irradiation. The results obtained indicated that the complex acts as a PS, resulting more efficient than cisplatin, a model platinum complex [85]. Intending to provide an increased bioavailability of the ruthenium complexes, Soliman and collaborators synthesized a ruthenium-polylactic acid complex (122, Fig.…”

A study on structure and property of two complexes involving platinum(II), eugenol and 8‐hydroxyquinoline derivatives

“…This is in a good agreement with previous works related to interactions that stabilize the Pt(II) complexes. [20,21] Potential geometries of C2-x structures could be envisioned on the basis of purely Coulombic attractions. The regions of positive potential are associated with the aromatic ring, while the negative areas are mainly addressed at the O1, O2 atoms and along the extension of C-H bonds near the N heteroatom in the ring.…”