Visible lesion thresholds and model predictions for Q-switched 1318-nm and 1540-nm laser exposures to porcine skin

Zohner, Justin J.; Schuster, Kurt J.; Chavey, Lucas J.; Stolarski, David J.; Kumru, Semih S.; Rockwell, Benjamin A.; Thomas, Robert J.; Cain, Clarence P.

doi:10.1117/12.644757

Cited by 4 publications

(2 citation statements)

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“…ED 50 (J cm -2 ) 1-Hour Reading ED 50 (J cm -2 ) 24-Hour Reading 1318 nm 5-mm beam diameter 50 ns 4 6.5 (7.0 -5.9) 10.5 (11.1 -10.0) 1540 nm 5-mm beam diameter 30 ns 4 6.3 (6.8 -5.8) 6.1 (6.5 -5.5) 1540 nm 5-mm beam diameter 600 µs 3 6.4 (6.7 -6.2) 7.4 (7.8 -7.0)…”

Section: Laser Parameters Number Of Subjects and Exposuresmentioning

confidence: 99%

Comparative analysis of histological results of visible lesion thresholds for thermal and LIB induced skin damage at 1.3 μm and 1.5 μm

Zohner¹,

Stolarski

Pocock³

et al. 2007

SPIE Proceedings

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An assessment of skin damage caused by near-IR laser exposures is reported. The damage from two distinct laser-tissue temporal regimes is compared at two wavelengths (1.3 µm and 1.5 µm). Skin damage caused by thermal effects from single laser pulses is compared to damage caused by LIB (laser induced breakdown) using histological examinations. Modeling applications are explored to determine crossover points between thermal and photomechanical damage thresholds.

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Section: Laser Parameters Number Of Subjects and Exposuresmentioning

confidence: 99%

Comparative analysis of histological results of visible lesion thresholds for thermal and LIB induced skin damage at 1.3 μm and 1.5 μm

Zohner¹,

Stolarski

Pocock³

et al. 2007

SPIE Proceedings

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“…A recent study by Vincelette et al 8 determined the contribution of beam diameter to porcine skin MVL thresholds for 1070-nm laser exposure durations ranging from 10 ms to 10 s. DeLisi et al 9 further investigated skin injury response to 1070-nm lasers but at suprathreshold endpoints for 3-and 100-ms exposures in excised porcine tissue. Cain et al 10 and Montes de Oca et al 11 presented porcine skin MVL thresholds for light near 1315 nm and pulse durations of 0.35 ms, whereas Oliver et al 12 provided thresholds at 1319 nm for exposure durations of 0.25, 1, 2.5, and 10 s. Several porcine skin MVL threshold studies for 1540-nm laser are available, including for 30-ns, 13,14 0.6-, 13 0.8-, 15 and 60-ms pulses. 16 Chen et al [17][18][19] extensively studied the effects of 2000-nm laser porcine skin damage.…”

Section: Introductionmentioning

confidence: 99%

Thermal damage thresholds for multiple-pulse porcine skin laser exposures at 1070 nm

DeLisi¹,

Schmidt

Hoffman

et al. 2019

J. Biomed. Opt.

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As solid-state laser technology continues to mature, high-energy lasers operating in the near-infrared (NIR) band have seen increased utilization in manufacturing, medical, and military applications. Formulations of maximum permissible exposure limits establish guidelines for the safe use of these systems for a given set of laser parameters, based on past experimental and analytical studies of exposure thresholds causing injury to the skin and eyes. The purpose of our study is to characterize the skin response to multiple-pulsed laser exposures at the NIR wavelength of 1070 nm, at a constant beam diameter of 1 cm, using anesthetized Yucatan mini-pig subjects. Our study explores three constant total laser-on times of 0.01, 0.1, and 10 s as single-and multiplepulse sequences. Exposures consisting of 10, 30, and 100 pulses have identical individual pulse durations but different duty cycles in order to include variable degrees of thermal additivity. A plurality of three observers quantifies skin damage with the minimally visible lesion metric, judged at the 1-and 24-h intervals postexposure. Calculation of the median effective dose (ED 50) provides injury thresholds for all exposure conditions, based on varying laser power across subjects. The results of this study will provide a quantitative basis for the incorporation of multiple-pulsed laser exposure into standards and augment data contained in the existing ED 50 database.

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Skin damage thresholds with continuous-wave laser exposures at the infrared wavelength of 1319 nm

Oliver

Harbert²,

Noojin³

et al. 2011

SPIE Proceedings

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Visible lesion thresholds and model predictions for Q-switched 1318-nm and 1540-nm laser exposures to porcine skin

Cited by 4 publications

References 0 publications

Comparative analysis of histological results of visible lesion thresholds for thermal and LIB induced skin damage at 1.3 μm and 1.5 μm

Comparative analysis of histological results of visible lesion thresholds for thermal and LIB induced skin damage at 1.3 μm and 1.5 μm

Thermal damage thresholds for multiple-pulse porcine skin laser exposures at 1070 nm

Skin damage thresholds with continuous-wave laser exposures at the infrared wavelength of 1319 nm

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