Visfatin reduces hippocampal CA1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion

Erfani, Sohaila; Khaksari, Mehdi; Oryan, Shahrbanoo; Shamsaei, Nabi; Aboutaleb, Nahid; Nikbakht, Farnaz; Jamali-Raeufy, Nida; Gorjipour, Fazel

doi:10.1016/j.npep.2014.12.004

Cited by 40 publications

(22 citation statements)

References 22 publications

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“…Ischemia leads to selective loss of vulnerable neurons by apoptosis in specific brain regions. Certain areas of the brain as well as certain types of neurons are more sensitive to cerebral ischemia (e.g., pyramidal neurons of the hippocampus) [2,3]. Moreover, it has been reported that apoptosis is the most important process in hippocampal neurons exposed to transient global ischemia [4].…”

Section: Introductionmentioning

confidence: 99%

Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation

et al. 2015

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Ischemia induces physiological alterations in neurons that lead to cell death. This study investigated the effects of pre-ischemic exercise on CA3 neurons. Rats were divided into three groups. Animals in the exercise group were trained 5 days a week for 4 weeks. Ischemia was induced by occlusion of both common carotid arteries (CCAs) for 20 min. Apoptotic cell death was detected by TUNEL assay. Furthermore, expression of different proteins was determined by immunohistochemical staining. The number of TUNEL-positive cells was significantly increased in the ischemia group, but pre-ischemic exercise significantly reduced apoptotic cell death (P < 0.001). In addition, our results showed a significant increase in the Bax/Bcl-2 ratio in the ischemia group. Pre-ischemic exercise attenuated this ratio (P < 0.05). Furthermore, the number of active caspase-3-positive neurons was significantly increased in the ischemia group, which was reduced markedly by exercise preconditioning (P < 0.05). This study showed that pre-ischemic exercise can exert neuroprotective effects against ischemia in CA3 neurons.

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Section: Introductionmentioning

confidence: 99%

Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation

et al. 2015

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“…Regarding the effects of smoking on the cognitive performance of the workers in the automotive industry, the results of our study demonstrated the relationship between smoking and cognitive performance. Although brain function and mental performance in the work environment are affected by environmental factors such as light, sound, and temperature, some studies also investigated the effect of using nicotine-containing products such as cigarettes on the mental and brain functions in different age groups and genders and reported various results (Ernst et al, 2001;Kalmijn et al, 2002). Smoking cigarettes and other nicotine-containing products are associated with reduced mental performance as demonstrated by the CPT method in this study, and there is a strong dose-response relationship between smoking rate and mental function (Berkman et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Alimohammadi

Kanrash

Abolaghasemi

et al. 2019

Basic Clin. Neurosci. J.

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Introduction:Noise is an environmental stressor and can cause or exacerbate mental disorders, and affect the individual performance in certain conditions. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance of the workers in the automotive industry. Methods:This research is a descriptive-analytical study with a cross-sectional design conducted on 300 workers randomly assigned into two groups of noise-exposed and nonexposed. They were examined using computerized tests, including the Tower of London test (TOL), Continuous Performance test (CPT), and Stroop test. The sound pressure levels were measured based on an 8-hour equal-loudness contour in each group according to ISO 9612 standard, using the Testo CEL-815 sound level meter. Results:The study of combined effects of noise and smoking on 12 CPT indicators using the 2-way Analysis of Variance (ANOVA) indicate that noise and smoking factors had a significant impact on the mean number of errors and correct responses in the third 50-stimuli stage, the mean number of errors and correct responses in the second 50-stimuli stage with P<0.001, P<0.001, P=0.012 and P<0.001 for smoking respectively, but only noise affected the other 7 indicators (P<0.001). Conclusion:Smoking and noise have negative impacts on concentration, attention, and cognitive processing speed, which can lead to an individual's mistakes and delayed decision making at the workplace. Highlights• Brain function, cognitive processing speed, and individual performance are significantly lower in smokers compared to non-smokers.• Noise and smoking have significant effects on cognitive performance indicators.• High noise exposure is associated with the risk of an increased number of errors in responding to the test stimuli.• Addiction to cigarettes and other nicotine-containing products harms cognitive performance, including executive functions. Plain Language SummaryExcessive noise in industrial environments can cause hearing impairment, speech problems, sleep disorders, noise annoyance, and decreased efficiency of the workers. This study aimed to evaluate the combined effects of noise and smoking on the cognitive performance and psychological flexibility of workers in the automotive industry in Iran. The workers were assessed by proper tools to examine their mental performance and responses to low-or high-frequency noises. We found that long-time exposure to noise significantly affects the individual's performance and psychomotor speed, which resulted in impaired concentration, poor working performance, and increased mistakes at work. This study revealed the relationship between smoking and brain functions in terms of response type and decision-making.

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“…Generally, treatment with bumetanide and ABA training compared with the only ABA training led to more improvements in children with autism. No undesirable effects of bumetanide were observed (Du et al, 2015).…”

Section: Lemonniermentioning

confidence: 91%

“…The power of α frequency elevated following the treatment that may explain another mechanism contributing to the improvement of the patients in behavioral and cognitive functions. Du et al, 2015 Sixty children with autism (two categories:…”

Section: Bruining Et Al 2015mentioning

confidence: 99%

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study

Mollajani

Joghataei

Tehrani‐Doost

2019

Basic Clin. Neurosci. J.

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Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in communications and social interactions, as well as restricted interests or stereotyped behaviors. Interventions applied for this disorder are based on multi-modal approaches, including pharmacotherapy. No definitive cure or medication has been introduced so far; therefore, researchers still investigate potential drugs for treating ASD. One of the new medications introduced for this purpose is bumetanide. The present article aimed to review the efficacy of this drug on the core symptoms of ASD and its potential side effects. Methods:We searched all papers reported on pharmacokinetics, pharmacodynamics, efficacy, and adverse effects of bumetanide on animal models and humans with ASD. The papers were extracted from the main databases of PubMed, Web of Science, and Scopus. Results:The findings revealed that cortical neurons have high Chloride ion (Cl−)i and excitatory actions of gamma-aminobutyric acid in the valproic acid animal model with ASD and mice with fragile X syndrome. Bumetanide, which has been introduced as a diuretic, is also a high-affinity-specific Na+-K+-Cl− cotransporter (NKCC1) antagonist that can reduce Cl− level. The results also indicate that bumetanide can attenuate behavioral features of autism in both animal and human models. Moreover, the studies showed that such medication could activate fusiform face area in individuals with ASD while viewing emotional faces. Also, recent findings suggest that a dose of 1 mg/d of this drug, taken twice daily, might be the best compromise between safety and efficacy. Conclusion:Recent studies provided some evidence that bumetanide can be a novel pharmacological agent in treating core symptoms of ASD. Future studies are required to confirm the efficacy of this medication in individuals with ASD. Citation: Mollajani, R., Taghi Joghataei, M., & Tehrani-Doost, M. (2019). Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study. Basic and Clinical Neuroscience, 10(5), 433-442. http://dx.doi.

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Visfatin reduces hippocampal CA1 cells death and improves learning and memory deficits after transient global ischemia/reperfusion

Cited by 40 publications

References 22 publications

Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation

Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation

Combined Effect of Noise and Smoking on the Cognitive Performance of Automotive Industry Workers

Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study

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