Visfatin level in children and adolescents with autoimmune thyroiditis

Abstract

Background: This study aims to assess the levels of visfatin in children and adolescents with autoimmune thyroiditis (AIT) and its relationship with disease-related variables. Methods: The study included 84 children and adolescents with AIT and 84 healthy subjects. Measurements of fasting glucose, insulin, thyroid-stimulating hormone (TSH), free thyroxin (FT4), antithyroid peroxidase antibodies (TPOAb) and antithyroglobulin antibody (TgAb) were completed, with assessment of visfatin levels. Results: Overt hypothyroidism was diagnosed in 58 cases, while subclinical hypothyroidism was diagnosed in 26 of the studied patients. Total studied cases, overt and subclinical subgroups had significantly higher levels of TSH, HOMA-IR, TPOAb, TgAb and visfatin and significantly lower FT4 level compared with the control. Spearman correlation analysis revealed that visfatin was correlated positively with BMI, homeostasis model assessment (HOMA-IR), TSH and TPOAb, while inversely correlation with FT4. In logistic regression analysis, visfatin was correlated only with TPOAb. Conclusions: This preliminary study provides evidence of significantly higher level of visfatin in children and adolescents with AIT. Visfatin might have a potential role in the pathogenesis of AIT, which needs to be validated by measuring immunological responses in children and adolescents with AIT.

Does euthyroid mean healthy? Effect of restoration of thyroid function on body composition, insulin resistance and visfatin concentrations in women with hypo- and hyperthyroidism.

“…body mass index, waist-to-hip ratio, or skin fold) (25,26). We have confirmed our previous findings that serum visfatin correlates with TPOAbs in hypothyroid patients, which has been recently also reported in children (27). Likewise, Caixas at al.…”

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

“…In previous studies, circulating visfatin levels in T1DM were higher [80,81] or lower [82][83][84] compared to healthy controls. Recent studies have suggested a relationship between increased visfatin levels and chronic autoimmune thyroiditis [78,85]. Our study showed non-significantly lower serum levels of visfatin in women with T1DM compared with women in the control group.…”

“…Based on previous studies, visfatin has been identified as a potential biomarker of insulin resistance, obesity, metabolic syndrome, type 2 diabetes mellitus, and CV disease [76]. Moreover, recent reports have indicated its association with the development of inflammation in autoim-mune inflammatory disorders [20,[77][78][79]. However, results concerning visfatin in T1DM and/or HD are limited and conflicting.…”

Pro-inflammatory adiponectin in pediatric-onset multiple sclerosis

“…Visfatin is also thought to have anti-inflammatory properties. Interestingly its levels have been found to be elevated in several autoimmune conditions including thyroiditis and arthritis, 40,41 where it has been suggested that it may be induced in response to inflammation, possibly serving as a "negative feed-back" loop aimed at acquiescing inflammation. We also note that the adipokine abnormalities we identified in children with MS compared to the disease controls might reflect differences between recurrent/ongoing versus monophasic disease activity.…”