Viscotoxin, ein neuer Inhaltsstoff der Mistel (Viscum album L)

Winterfeld, K.; Bijl, Leonard Hugo

doi:10.1002/jlac.19495610204

Cited by 28 publications

(10 citation statements)

References 10 publications

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“…In the Middle Ages, the European mistletoe Viscum album was already known in folk medicine to contain a blood pressurelowering substance that could lead to death [cited in 82,83,97]. It took several ages before part of this activity was ascribed to a group of small proteins, the viscotoxins [ 104]. Later, these proteins were found to be highly homologous with the thionins from wheat.…”

Section: Introductionmentioning

confidence: 99%

Thionins: properties, possible biological roles and mechanisms of action

1994

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Thionins are low-molecular-weight proteins (M(r) ca. 5000) occurring in seeds, stems, roots and leaves of a number of plant species. The different members of this family of plant proteins show both sequence and structural homology, and are toxic to bacteria, fungi, yeasts and various naked cells in vitro. Toxicity requires an electrostatic interaction of the positively charged thionin with the negatively charged phospholipids making up the membrane, followed by either pore formation or a specific interaction with a certain lipid domain. This domain might be composed of phosphoinositides, which mediate transduction of environmental signals in eukaryotes. Their in vitro toxicity to plant pathogenic bacteria and fungi could reflect a direct role in plant defence, although, in view of the many divergent activities displayed by thionins both in vitro and in vivo, a biological role other than inhibition of microbial growth is equally plausible.

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Section: Introductionmentioning

confidence: 99%

Thionins: properties, possible biological roles and mechanisms of action

1994

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“…The hypotensive effect of crude extracts of Viscum album turned out to be due to several substances. Transient effects were caused by choline and y-aminobutyric acid (Samuelsson, 1959) but the main effect was a toxic manifestation which could be attributed to a mixture of some small, basic proteins, previously isolated by Winterfeld and Bijl (1948) and given the name viscotoxin.…”

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confidence: 98%

Mistletoe Toxins

Samuelsson¹

1973

Systematic Zoology

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“…Mistletoe extracts are complex multicomponent mixtures and contain inter alia mistle toe lectins (ML), viscotoxins, enzymes, peptides, amino acids, thiols, amines, polysaccharides, cycitoles, lipids, phytosterols, triterpenes, flavonoids, phenylpropanes, and minerals. Among the pharmacologically active compounds identified are the lectins ML I, II, and III [2], viscotoxins [3,4], oligo-and polysaccharides [5,6], lipophilic extracts [7], and several others [8].…”

Section: Cd3mentioning

confidence: 99%

Immunomodulatory Effects of <i>Viscum album</i> Extracts on Natural Killer Cells: Review of Clinical Trials

Braedel-Ruoff¹

2010

Forsch Komplementmed

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Extracts produced from Viscum album L. (mistletoe) are widely used in complementary medicine for the treatment of cancer. In many preclinical and clinical studies, Viscum album extracts were shown to exert immunomodulatory functions. Natural killer (NK) cells play an important role in cell-mediated immune responses against tumor cells. This article reviews clinical trials that address the influence of the mistletoe extract Iscador^® on NK cells and discusses the results with regard to the NK cell functions assayed, to putative underlying mechanisms, and to the role of different mistletoe components. Conclusion: Although many trials demonstrated a positive effect of Iscador^® treatment on NK cell function, further dedicated studies with optimized treatment schedules and comparable mistletoe doses are necessary to confirm these results regarding involvement of NK cells on the immunomodulatory functions of Iscador^® therapy and to investigate the clinical relevance of these findings.

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Viscotoxin, ein neuer Inhaltsstoff der Mistel (Viscum album L)

Cited by 28 publications

References 10 publications

Thionins: properties, possible biological roles and mechanisms of action

Thionins: properties, possible biological roles and mechanisms of action

Mistletoe Toxins

Immunomodulatory Effects of <i>Viscum album</i> Extracts on Natural Killer Cells: Review of Clinical Trials

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