Viscoelastic Properties of Normal and Infarcted Myocardium Measured by a Multifrequency Shear Wave Method: Comparison with Pressure-Segment Length Method

Pislaru, Cristina; Urban, Matthew W.; Pislaru, Sorin; Kinnick, Randall R.; Greenleaf, James F.

doi:10.1016/j.ultrasmedbio.2014.03.004

Cited by 50 publications

(76 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As was indicated previously, a number of studies have been performed to measure the potential of using SWEI measurements for systolic and diastolic functional assessment . Pernot et al reported a linear relationship between the maximum shear stiffness measurement and the intra‐ventricular pressure in systole after using an inotropic agent; the results reported here are consistent with those results .…”

Section: Discussionsupporting

confidence: 90%

“…We have previously investigated the potential of SWEI to provide contractility, compliance, and relaxation time constant measurements for cardiac function assessment . There are a number of publications regarding cardiac functional assessment using this method, and further details are included in the discussion section . However, the relationship between the intraventricular pressure and SWEI or ARFI measurements during the cardiac cycle has not been studied.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Measuring Intraventricular Pressure Using Ultrasound Elastography

Vejdani‐Jahromi

Freedman

Trahey

et al. 2018

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Measuring Intraventricular Pressure Using Ultrasound Elastography

Vejdani‐Jahromi

Freedman

Trahey

et al. 2018

J of Ultrasound Medicine

View full text Add to dashboard Cite

show abstract

“…Other techniques are now under development to estimate myocardial shear elasticity/viscoelasticity [2, 5, 13, 19, 29, 38, 42, 43]; however, transthoracic measurements are still technically challenging and require special equipment or are based on magnetic resonance imaging, which has limited availability. Conversely, TDI is now available on all commercial systems for cardiac imaging.…”

Section: Discussionmentioning

confidence: 99%

Wave propagation of myocardial stretch: correlation with myocardial stiffness

2014

Self Cite

View full text Add to dashboard Cite

The mechanism of flow propagation during diastole in the left ventricle (LV) has been well described. Little is known about the associated waves propagating along the heart wall s. These waves may have a mechanism similar to pulse wave propagation in arteries. The major goal of the study was to evaluate the effect of myocardial stiffness and preload on this wave transmission. Methods Longitudinal late diastolic deformation and wave speed (Vp) of myocardial stretch in the anterior LV wall were measured using sonomicrometry in sixteen pigs. Animals with normal and altered myocardial stiffness (acute myocardial infarction) were studied with and without preload alterations. Elastic modulus estimated from Vp (EVP; Moens-Korteweg equation) was compared to incremental elastic modulus obtained from exponential end -diastolic stress-strain relation (ESS). Myocardial distensibility and α-and β-coefficients of stress-strain relations were calculated. Results Vp was higher at reperfusion compared to baseline (2.6±1.3 m/s vs. 1.3±0.4 m/s; p=0.005) and best correlated with ESS (r 2=0.80, p<0.0001), β-coefficient (r2=0.78, p<0.0001), distensibility (r2=0.47, p=0.005), and wall thickness/diameter ratio (r2=0.42, p=0.009). Elastic moduli (EVP and ESS) were strongly correlated (r2=0.83, p<0.0001). Increasing preload increased Vp and EVP and decreased distensibility. At multivariate analysis, ESS, wall thickness, and end-diastolic and systolic LV pressures were independent predictors of Vp (r2model=0.83, p<0.0001). Conclusions The main determinants of wave propagation of longitudinal myocardial stretch were myocardial stiffness and LV geometry and pressure. This local wave speed could potentially be measured noninvasively by echocardiography.

show abstract

“…[12]–[14]), to the best of our knowledge, there is no published research that has described relaxation time constant measurements of the heart using ARFI and SWEI. In this paper, we investigate the relationship between ARFI and SWEI measures of the relaxation time constant and the systolic/diastolic stiffness ratio.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart

Vejdani‐Jahromi

Nagle

Yang

et al. 2016

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

In the past decade, there has been an increased interest in characterizing cardiac tissue mechanics utilizing newly developed ultrasound-based elastography techniques. These methods excite the tissue mechanically and track the response. Two frequently used methods, acoustic radiation force impulse and shear wave elasticity imaging (ARFI and SWEI), have been considered qualitative and quantitative techniques providing relative and absolute measures of tissue stiffness respectively. Depending on imaging conditions, it is desirable to identify indices of cardiac function that could be measured by ARFI and SWEI and to characterize the relationship between the measures. In this study, we have compared two indices (i.e. relaxation time constant used for diastolic dysfunction assessment and systolic/diastolic stiffness ratio) measured nearly simultaneously by M-mode ARFI and SWEI techniques. We additionally correlated ARFI-measured inverse displacements with SWEI measured values of the shear modulus of stiffness. For the eight animals studied, the average relaxation time constant ( ) measured by ARFI and SWEI were (69±18 ms, R2=0.96) and (65±19 ms, R2=0.99), (ARFI-SWEI inter-rater agreement = 0.90). Average systolic/diastolic stiffness ratio for ARFI, and SWEI measurements were 6.01±1.37 and 7.12±3.24 respectively (agreement=0.70). Shear modulus of stiffness (SWEI) was linearly related to inverse displacement values (ARFI) with a 95% CI for the slope of 0.010–0.011 (1/μm)/(kPa) (R2=0.73). In conclusion, the relaxation time constant and the systolic/diastolic stiffness ratio were calculated with good agreement between the ARFI and SWEI derived measurements. ARFI relative and SWEI absolute stiffness measurements were linearly related with varying slopes based on imaging conditions and subject tissue properties.

show abstract

Viscoelastic Properties of Normal and Infarcted Myocardium Measured by a Multifrequency Shear Wave Method: Comparison with Pressure-Segment Length Method

Cited by 50 publications

References 45 publications

Measuring Intraventricular Pressure Using Ultrasound Elastography

Measuring Intraventricular Pressure Using Ultrasound Elastography

Wave propagation of myocardial stretch: correlation with myocardial stiffness

A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart

Contact Info

Product

Resources

About