Measuring Intraventricular Pressure Using Ultrasound Elastography

Vejdani‐Jahromi, Maryam; Freedman, Jenna; Trahey, Gregg E.; Wolf, Patrick D.

doi:10.1002/jum.14795

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Therefore, a high correlation between SWV values and cardiac function parameters such as contraction efficiency and relaxation rate were determined, as well as a moderate correlation between SWV values and graft workload and end-diastolic pressure [ 25 ]. SWV has also been utilized to perform similar measurements on rabbit hearts during Langendorff machine perfusion and working heart modality, where the SWV values correlated to myocardial contractility, diastolic function, and intraventricular pressure [ 26 – 30 ]. The value of SWV as an assessment technique, if further developed, could be immense due to its capabilities for providing quantitative measurements of a given graft’s relative transplantability preserved via SCS or machine perfusion.…”

Section: Novel Imaging-based Experimental Assessment Techniquesmentioning

confidence: 99%

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

et al. 2023

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Purpose of the Review The current lack of objective and quantitative assessment techniques to determine cardiac graft relative viability results in risk-averse decision-making, which negatively impact the utilization of cardiac grafts. The purpose of this review is to highlight the current deficiencies in cardiac allograft assessment before focusing on novel cardiac assessment techniques that exploit conventional and emerging imaging modalities, including ultrasound, magnetic resonance, and spectroscopy. Recent Findings Extensive work is ongoing by the scientific community to identify improved objective metrics and tools for cardiac graft assessment, with the goal to safely increasing the number and proportion of hearts accepted for transplantation. Summary This review briefly discusses the in situ and ex vivo tools currently available for clinical organ assessment, before focusing on the individual capabilities of ultrasound, magnetic resonance, and spectroscopy to provide insightful, non-invasive information regarding cardiac graft functional and metabolic status that may be used to predict outcome after transplantation.

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Section: Novel Imaging-based Experimental Assessment Techniquesmentioning

confidence: 99%

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

et al. 2023

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“…Thus, an expression for β in terms of stress can be produced by substituting (19) into (18), which results in…”

Section: B Spherical Pressure-vessel Model Of the Bladdermentioning

confidence: 99%

Non-Invasive Measurement of the Internal Pressure of a Pressurized Biological Compartment Using Lamb Waves

Rosen¹,

Larson²,

Alizad³

et al. 2022

IEEE Trans. Biomed. Eng.

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In this study, we propose a mechanical analysis for estimating the internal pressure of a finitely deformed spherical compartment from Lamb wave measurements. The proposed analysis produces a dispersion relation associating Lamb wave speed with pressure using limited material parameters (only a strain stiffening term). The analysis was validated on ultrasound bladder vibrometry (UBV) experiments collected from 9 ex vivo porcine bladders before and after formalin cross-linking. Estimated pressures were compared with pressures measured directly by a pressure transducer. The proposed analysis proved broadly effective at estimating pressure from UBV based Lamb wave without calibration as demonstrated by the observed concordance between estimated and measured pressures (Lin’s CCC = 0.82 (0.66–0.91). Theoretical limitations and potential refinements to improve the accuracy and generality of the approach are discussed.

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“…These measurements can also sort out the remaining uncertainties in literature how other factors such as loading but also a combination of contractility and intrinsic stiffness (in for example an infarct) affect SWE measurements in diastole and systole. A preload independence of diastolic and systolic wave speed measurements has been suggested 2 , whereas other studies showed that an increase in ventricular or intra-myocardial pressure affected wave propagation speed in a Langendorff-prepared set-up 8 , 9 . We therefore hypothesized that increased ventricular pressure can induce an apparent stiffening of the myocardium due to the intrinsic material non-linearity.…”

Section: Introductionmentioning

confidence: 99%

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

Caenen,

Keijzer,

Bézy

et al. 2023

Sci Rep

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Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure–volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure–volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure–volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury.

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Measuring Intraventricular Pressure Using Ultrasound Elastography

Abstract: We have shown that SWEI measurements are linearly related to IVP; therefore, pressure-based indices could potentially be derived from SWEI ultrasound elastography. The feasibility of using SWEI to estimate IVP with a single point calibration was also shown in this study.

Cited by 5 publications

References 29 publications

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Novel Imaging Technologies for Accurate Assessment of Cardiac Allograft Performance

Non-Invasive Measurement of the Internal Pressure of a Pressurized Biological Compartment Using Lamb Waves

Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs

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