Viscoelastic Properties and Morphology of Mumio-based Medicated Hydrogels

Abstract

Abstract. Novel medicated hydrogels were prepared (by moist heat treatment) with PVA, agar, mumio, mare's milk (MM), seabuckthorn oil (SB oil) and salicylic acid (SA) for wound dressing/healing application. Scanning electron micrographs (SEM) show highly porous structure of these hydrogels. The swelling behaviour of the hydrogels in physiological solution displays remarkable liquid absorption property. The knowledge obtained from rheological investigations of these systems may be highly useful for the characterization of the newly developed topical formulations. In the present study, an oscillation frequency sweep test was used for the evaluation of storage modulus (G'), loss modulus (G"), and complex viscosity (Ș * ) of five different formulations, over an angular frequency range from 0.1 to 100 rad.s -1 . The influence of healing agents and swelling effect on the rheological properties of mumio-based medicated hydrogels was investigated to judge its application on uneven surface of body.

Resolving the Conflict between Strength and Toughness in Bioactive Silica–Polymer Hybrid Materials

“…In order to investigate the dependence of I/O weight ratio on the hybrids’ viscoelastic properties, dynamic mechanical analysis (DMA) measurements were performed . The results of sweep frequency show that the storage modulus ( E′ ) (Figure e) of the five hybrids is 15 to 30 times higher than the corresponding loss modulus ( E′′ ) (Figure f), confirming the formation of elastic solid hybrids. , We also note that no significant changes in E′ and E′′ values could be observed in any of the hybrids over the tested frequency range (0.01–10 Hz), indicating a rubber plateau like behavior and cross-linked structures of the hybrid networks . The values of tan (δ) equal to E′′/E′ are ≤0.06 for all five hybrids at 1 Hz (Figure S7), representing elastic properties of the hybrid materials.…”

“…25,49 We also note that no significant changes in E′ and E′′ values could be observed in any of the hybrids over the tested frequency range (0.01−10 Hz), indicating a rubber plateau like behavior and cross-linked structures of the hybrid networks. 50 The values of tan (δ) equal to E′′/E′ are ≤0.06 for all five hybrids at 1 Hz (Figure S7), representing elastic properties of the hybrid materials.…”

Development of dual crosslinked mumio-based hydrogel dressing for wound healing application: Physico-chemistry and antimicrobial activity

“…Mumio, also known as mumijo or shilajit is a widely used traditional medicine, especially in Russia, Mongolia, Iran, Kazakhstan and Kyrgyzstan (Aiello et al, 2011;Sukhdolgor and Orkhonselenge, 2011). It is a thick, sticky tar-like substance and mainly found in rock crevices at altitudes of 2000 to 5000 meters high in mountainous regions of Asia and Antarctica (Garedew et al, 2004;Zandraa et al, 2011). Generally, Mumio contains about 14-20% moisture, 18-20% minerals; 13-17% proteins; 4-4.5% lipids; 3.3-6.5% steroids, 18-20% nitrogen-free compounds, 1.5-2% carbohydrates, and 0.05-0.08% alkaloids, amino acids and other compounds with nitrogen, essentials oils and vitamins etc (Konstantinov et al, 2013).…”