Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression

Allen, Kyle D.; Athanasiou, Kyriacos A.

doi:10.1016/j.jbiomech.2004.11.012

Cited by 141 publications

(186 citation statements)

References 33 publications

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“…The biomechanical testing indicates that degeneration diminished their viscoelastic properties, stress relaxation, damping and dissipation capacities, in accordance with previous studies [12][13][14]. However, the large scatter in the results was normal which caused a poor correlation.…”

Section: Discussionsupporting

confidence: 89%

Biomechanics of the Intervertebral Disc in Compression: Experimental and Numerical Study

Gutiérrez¹,

Alonso²,

Rosas³

2015

JMEA

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Loading history and age are factors for disc degeneration and disc biomechanics; however, their relationship is unclear. To evaluate disc biomechanics, we conducted an experimental, anatomical and numerical approach to distinguish discs with mild and severe degeneration. In the experimental procedure, 10 cadaveric lumbar discs are tested to static and dynamic compression, and the elastic and viscous moduli and the dynamic parameters are reported. The morphology of disc degeneration is gained with MRI (magnetic resonance imaging) and used to generate a nonlinear finite element model of a degenerated disc, and assisted with the experimental results in order to numerically investigate the distribution of stresses and strains within the disc. The results show a promising methodology for the study of intervertebral disc biomechanics and in general other tissues, organs and medical devices.

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Section: Discussionsupporting

confidence: 89%

Biomechanics of the Intervertebral Disc in Compression: Experimental and Numerical Study

Gutiérrez¹,

Alonso²,

Rosas³

2015

JMEA

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“…The tissue was pre-stressed with 15 cycles of 5% strain followed by sequential stress-relaxation under 10 and 20% strain, using a rate of 10% tissue thickness per second. A load-displacement curve was generated and fitted using a Kelvin-solid viscoelastic model, from which the instantaneous and relaxation modulus values were derived [33]. A second 2 mm biopsy punch was made adjacent to the first, resulting in a dog-bone-shaped tensile specimen in the neocartilage.…”

Section: Neocartilage Biochemical and Mechanical Analysismentioning

confidence: 99%

Neocartilage integration in temporomandibular joint discs: physical and enzymatic methods

Murphy

Arzi

Prouty

et al. 2015

J. R. Soc. Interface.

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Integration of engineered musculoskeletal tissues with adjacent native tissues presents a significant challenge to the field. Specifically, the avascularity and low cellularity of cartilage elicit the need for additional efforts in improving integration of neocartilage within native cartilage. Self-assembled neocartilage holds significant potential in replacing degenerated cartilage, though its stabilization and integration in native cartilage require further efforts. Physical and enzymatic stabilization methods were investigated in an in vitro model for temporomandibular joint (TMJ) disc degeneration. First, in phase 1, suture, glue and press-fit constructs were compared in TMJ disc intermediate zone defects. In phase 1, suturing enhanced interfacial shear stiffness and strength immediately; after four weeks, a 15-fold increase in stiffness and a ninefold increase in strength persisted over press-fit. Neither suture nor glue significantly altered neocartilage properties. In phase 2, the effects of the enzymatic stabilization regimen composed of lysyl oxidase, CuSO 4 and hydroxylysine were investigated. A full factorial design was employed, carrying forward the best physical method from phase 1, suturing. Enzymatic stabilization significantly increased interfacial shear stiffness after eight weeks. Combined enzymatic stabilization and suturing led to a fourfold increase in shear stiffness and threefold increase in strength over press-fit. Histological analysis confirmed the presence of a collagen-rich interface. Enzymatic treatment additionally enhanced neocartilage mechanical properties, yielding a tensile modulus over 6 MPa and compressive instantaneous modulus over 1200 kPa at eight weeks. Suturing enhances stabilization of neocartilage, and enzymatic treatment enhances functional properties and integration of neocartilage in the TMJ disc. Methods developed here are applicable to other orthopaedic soft tissues, including knee meniscus and hyaline articular cartilage.

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“…In tension and compression, the porcine disc's posterior band has greater properties compared with the anterior band (Detamore and Athanasiou, 2003). Additionally, the lateral region demonstrates greater compressive properties compared with the medial region (Lumpkins and McFetridge, 2009), also observed by Allen and Athanasiou (2006) on the superior surface of the disc. Tensile properties in the attachments were consistent with these findings.…”

Section: Discussionmentioning

confidence: 97%

Tensile Characterization of Porcine Temporomandibular Joint Disc Attachments

Murphy

Arzi

et al. 2013

J Dent Res

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The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ pathologies, including disc displacement. In the present study, a porcine model was used to characterize the attachments in tension anteroposteriorly and mediolaterally, based on previously identified similarities in the porcine and human masticatory behaviors and discal properties. Tensile stiffness, strength, toughness, and maximum strain were quantified. Collagen alignment was characterized via polarized light and scanning electron microscopy. Anisotropy was demonstrated in all attachments, with the exception of the anterior inferior attachment. Anteroposteriorly, the lateral attachment was stiffest (8.3 MPa) and the anterior superior was least stiff (1.4 MPa). Mediolaterally, the posterior superior attachment was stiffest (16.3 MPa) and the medial was least stiff (1.4 MPa). The greatest strain was observed in the lateral attachment in the mediolateral direction and the posterior superior attachment in the anteroposterior direction. With greatest strains in the most commonly observed directions of disc displacement, it is suggested that compromise in the posterior and lateral attachments contributes to partial lateral and anterior disc displacement.KEY WORDS: cartilage, extracellular matrix (ECM), microscopy, regenerative medicine, stress analysis, temporomandibular disorders (TMD). A supplemental appendix to this article is published electronically only at http://jdr.sagepub.com/supplemental.

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Viscoelastic characterization of the porcine temporomandibular joint disc under unconfined compression

Cited by 141 publications

References 33 publications

Biomechanics of the Intervertebral Disc in Compression: Experimental and Numerical Study

Biomechanics of the Intervertebral Disc in Compression: Experimental and Numerical Study

Neocartilage integration in temporomandibular joint discs: physical and enzymatic methods

Tensile Characterization of Porcine Temporomandibular Joint Disc Attachments

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