Visceral Obesity and Risk of High Grade Disease in Clinical T1a Renal Cell Carcinoma

Abstract

Increased visceral obesity was found to be strongly associated with higher Fuhrman grade in patients with cT1a renal cell carcinoma. Further studies are needed to confirm these findings and discover the underlying biological mechanism.

Association between visceral and subcutaneous adiposity and clinicopathological outcomes in non-metastatic clear cell renal cell carcinoma

“…Furthermore, regardless of BMI, women appear to have higher levels of SFA and fat mass than men. 8,10,16,17,28 Similarly, in the current study the correlation between BMI and VFA (r = 0.542) was relatively weak when compared to that of BMI and SFA (r = 0.804) and BMI and TFA (r = 0.846). In addition, women had higher SFA but lower VFA than men, but did not differ from men with regard to BMI or TFA.…”

“…Unlike previous reports, they demonstrated that high VFA% was associated with a higher grade of RCC. 17 Two previous studies evaluated the predictive value of visceral adiposity in metastatic RCC patients treated with anti-angiogenic therapy, reporting contradicting results. While one study showed that higher than median VFA values were significantly associated with a shorter progression-free survival and OS, the other demonstrated an opposite correlation.…”

“…4,12 While the reported effects of BMI on RCC have been uniform, reports concerning the effect of visceral adiposity on the pathological and clinical outcomes of RCC are inconsistent. [13][14][15][16][17] Moreover, most previous studies evaluating the predictive value of visceral fat in non-metastatic RCC were conducted among Asian populations, which have relatively lower BMIs than Western populations, and may display a different relationship between BMI and body fat. 18,19 The aim of the current study was to evaluate whether visceral fat area (VFA) and subcutaneous fat area (SFA) were related to tumour characteristics and treatment outcomes in a group of surgically treated, non-metastatic, clear cell RCC (ccRCC) patients from the United States.…”

Metabolic Syndrome Prevalence in Renal Cell Cancer Patients

“…Their results point out a possible association between MetS and tumor carsinogenesis, eventhough we did not confirm any link either between MetS and nuclear grade or between MetS and RCC subtype. In another study, increased visceral obesity, a key component of MetS, was found to be strongly associated with higher Fuhrman grade in patients with clinical T1a RCC (Zhu et al, 2013). Since our results reflect the experience of a single institution, our study cohort may not have analogous regional or individual risk factors contributing to tumor aggressiveness or subtype formation with abovementioned studies.…”

The Relationship Between Visceral Obesity and the Clinicopathologic Features of Patients with Small Renal Masses

“…Zhu et al recently reported on a series of 186 patients with surgically treated T1a RCC. 17 They found significant relationships between the percentages of visceral adipose tissue and tumor size with higher Fuhrman grades. Similar to our findings, multivariate analysis showed that the percentages of visceral adipose tissue (OR 1.06, p = 0.0018) and tumor size (OR 1.91, p = 0.047) were independent predictors of high-grade cancer.…”