Visceral mast cell tumors in dogs: 10 cases (1982–1997)

Takahashi, Tomoko; Kadosawa, Tsuyoshi; Nagase, Masayuki; Matsunaga, Satoru; Mochizuki, Manabu; Nishimura, Ryohei; Sasaki, Nobuo

doi:10.2460/javma.2000.216.222

Cited by 85 publications

(104 citation statements)

References 11 publications

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“…Factors including histologic grade, World Health Organization stage, duration of disease, argyrophilic nucleolar organizer region count, completeness of surgical excision, DNA ploidy, tumor location, breed, and abnormal expression of the p53 tumor suppressor gene have been evaluated as prognostic indicators for MCT in dogs. [3][4][5][6][7][8][9][10][11][12][13][14][15] Tumor location affected the prognosis of dogs with incompletely resected MCT treated with radiation therapy in 1 study in which tumors of the extremities were associated with a lower metastatic rate, longer disease-free intervals, and longer survival times than tumors located on the trunk. 5 A more recent study determined that location did not affect outcome.…”

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confidence: 99%

Biologic Behavior and Prognostic Factors for Mast Cell Tumors of the Canine Muzzle: 24 Cases (1990–2001)

Gieger

Théon

Werner

et al. 2003

Veterinary Internal Medicne

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The medical records of 24 dogs with histologically confirmed mast cell tumors (MCT) of the muzzle were retrospectively evaluated to determine their biologic behavior and prognostic factors. Information on signalment, tumor grade and stage, treatment methods, and pattern of and time to failure and death was obtained from the medical record. Twenty-three dogs were treated with combinations of radiotherapy, surgery, and chemotherapy; 1 dog received no treatment. There were 2 Grade I, 15 Grade II, and 7 Grade III tumors. Tumors were stage 0 (n ϭ 8), stage 1 (5), stage 2 (6), stage 3 (4), and stage 4 (1). Mean and median survival times of treated dogs were 36 and 30 months, respectively. Prognostic factors affecting survival time included tumor grade and presence of metastasis at diagnosis. Dogs with Grade I and II tumors survived longer than dogs with Grade III tumors. Variables, including sex, age, gross versus microscopic disease, and treatment type were not found to affect survival. Local control rate was 75% at 1 year and 50% at 3 years. Tumor grade was the only variable found to affect local control. Dogs with Grade I tumors had longer disease-free intervals than those with Grade II tumors, and dogs with Grade II tumors had longer disease-free intervals than dogs with Grade III tumors. Eight of 9 dogs dying of MCT had local or regional disease progression. Muzzle MCT are biologically aggressive tumors with higher regional metastatic rates than previously reported for MCT in other sites.

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confidence: 99%

Biologic Behavior and Prognostic Factors for Mast Cell Tumors of the Canine Muzzle: 24 Cases (1990–2001)

Gieger

Théon

Werner

et al. 2003

Veterinary Internal Medicne

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“…The difference among the cell lines observed in this study might indicate the nature of the cell origin. VI-MC originated from intestinal MCTs, which have high potential for hematogenous metastasis [18]. Since LN is abundant in the basal lamina of blood vessels, the ability of VI-MC to adhere to LN may play a role in dissemination in intestinal MCTs.…”

Section: Discussionmentioning

confidence: 99%

“…Canine MCTs infrequently develop in other sites, including the oral cavity and intestines, which are associated with poorer prognoses [18,20].…”

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confidence: 99%

Role of .BETA.1 Integrins in Adhesion of Canine Mastocytoma Cells to Extracellular Matrix Proteins

Takahashi

Ohashi

Nakagawa

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. The interactions of tumor cells with the extracellular matrix (ECM) are a crucial step in invasion and metastasis. Integrins are adhesive molecules forming heterodimers with α and β subunits that play a definitive role in these interactions. In this study, mastocytoma (mast cell tumor: MCT) cell-ECM interaction was investigated using 3 canine MCT cell lines: CM-MC (originating from cutaneous MCT), VI-MC (originating from intestinal MCT), and CoMS (originating from oral MCT). Flow cytometric analysis showed that all cells highly expressed the integrin β1 and α1 through α5 subunits and that they moderately expressed the α6 subunit. In adhesion studies, CoMS weakly but spontaneously adhered to fibronectin (FN), which was enhanced by phorbol ester (TPA), while CM-MC and VI-MC required cell activation by TPA to adhere to FN. Anti-β1 and α5 integrin antibodies strongly inhibited cell adhesion to FN in CM-MC and CoMS and moderately inhibited cell adhesion in VI-MC. Only VI-MC adhered to laminin (LN) under activation by TPA. Anti-β1 integrin antibodies strongly inhibited cell adhesion to LN, but all anti-α integrin antibodies failed to inhibit cell adhesion to LN. No cells adhered to collagen types I and IV. Canine MCT cells from different origins expressed similar integrin patterns; however, there were some differences in adhesive behavior in response to various ECM proteins and activating stimuli.KEY WORDS: canine, extracellular matrix, integrin β1 subfamily, mastocytoma cell.

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“…Histopathological examination of tissue specimens is usually used to grade the tumour based on the degree of differentiation of the tumour cells (Takahashi et al, 2000;Misdorp, 2004). The staging of the tumour is clinical valuable to assist the surgeon in giving a more accurate prognosis and to provide a base-line data to which the surgeon can retrieve to evaluate therapeutic progress after initiation of therapy.…”

Section: Introductionmentioning

confidence: 99%

“…The staging of the tumour is clinical valuable to assist the surgeon in giving a more accurate prognosis and to provide a base-line data to which the surgeon can retrieve to evaluate therapeutic progress after initiation of therapy. The grading systems used to evaluate mast cell tumours are available in literature and can be summarized into 3 grades which are: undifferentiated or poorly differentiated, intermediately differentiated, and well-differentiated or mature according to the degree of cellularity, morphology of cancer cells and presence of mitotic figures (Takahashi et al, 2000;de Souza et al, 2001). Dogs that were diagnosed with grades 1 and 2 mast cell tumour have extremely poor survival rate after surgery (Grano et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Intestinal mast cell tumour in a dog: Case report and review of current literature

2016

Res. Opin. Anim. Vet. Sci.

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A 7-years-old spayed, female Siberian Husky dog was diagnosed with malignant poorly differentiated intestinal mast cell tumour. The dog had previous history of colonic perforation which might have been associated with this malignant disease. The dog was presented with ascites which is uncommon sign of this disease. The disease was tentatively diagnosed by cytologic examination of the abdominal fluid and later confirmed histologically and by immunostaining.

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Visceral mast cell tumors in dogs: 10 cases (1982–1997)

Cited by 85 publications

References 11 publications

Biologic Behavior and Prognostic Factors for Mast Cell Tumors of the Canine Muzzle: 24 Cases (1990–2001)

Biologic Behavior and Prognostic Factors for Mast Cell Tumors of the Canine Muzzle: 24 Cases (1990–2001)

Role of .BETA.1 Integrins in Adhesion of Canine Mastocytoma Cells to Extracellular Matrix Proteins

Intestinal mast cell tumour in a dog: Case report and review of current literature

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