Visceral involvement in primary neoplastic diseases of the reticulo-endothelial system

Lucia, S. P.; Mills, Harold; Lowenhaupt, Elizabeth; Hunt, Marjorie L.

doi:10.1002/1097-0142(195211)5:6<1193::aid-cncr2820050616>3.0.co;2-t

Cited by 40 publications

(7 citation statements)

References 26 publications

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“…In autopsy studies of patients with NHL, disease in the uterus was found in approximately 0.5% (17)(18)(19). The uterus is affected more commonly by chronic lymphocytic leukemia: 7.1 to 14.0% of patients have had uterine involvement (18,20).…”

Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

et al. 2000

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Non-Hodgkin's lymphomas (NHL) involving the uterus may be either low-stage neoplasms that probably arise in the uterus (primary) or systemic neoplasms with secondary involvement. In this study, 26 NHL involving the uterus are reported. Ten cases were stage I E or II E and are presumed to be primary. The mean age of patients at presentation was 55 years (range, 35 to 67 years), and abnormal uterine bleeding was the most frequent complaint (six patients). Nine of 10 tumors involved the cervix. Histologically, eight were diffuse large B-cell lymphoma (DLBCL); one was follicle center lymphoma, follicular, grade 1; and one was marginal zone B-cell lymphoma. At 5 years of clinical followup, five of six patients were alive after treatment. In 12 cases, uterine involvement was part of a systemic disease at diagnosis, either stage III E or IV. The mean patient age at the time that uterine involvement was detected was 58 years (range, 22 to 75 years); 6 of 12 had abnormal uterine bleeding. Six tumors involved both cervix and corpus, four corpus, and two cervix. Six were DLBCL; two were small lymphocytic lymphoma; three were follicle center lymphoma, follicular, grade 1 (two cases) or grade 2 (one case); and one was precursor T-cell lymphoblastic lymphoma. At 5 years of clinical follow-up, two of seven patients were alive after treatment. Four DLBCL arose in patients with incomplete clinical information; therefore, stage is unknown. We conclude that low-stage (presumably primary) uterine NHL are most commonly DLBCL, predominantly arise in the cervix, and cause abnormal uterine bleeding. High-stage NHL are a heterogeneous group of B-cell neoplasms that can involve the cervix or the corpus.

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Section: Discussionmentioning

confidence: 99%

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

et al. 2000

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“…Although previous HL involvement of the ovary has been reported, it is thought to be rare (33). The incidence reported from autopsy of patients with HL ranges from <1% to $5% (24,34). Although the safety is still to be established, at present patients with Hodgkin lymphoma constitute the majority of patients who have received reimplantation of cryopreserved ovarian tissue (9,10,12,19,20,22,28,35).…”

Section: Discussionmentioning

confidence: 99%

“…Although the risk of reintroducing malignant cells is thought to be high with some cancers such as leukemia (36%), the relative risk of ovarian involvement with Hodgkin lymphoma is assumed to be low (24). This report describes the detection of Hodgkin lymphoma within ovarian tissue removed for fertility preservation and emphasizes the importance of histologic examination of ovarian tissue before freezing.…”

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confidence: 93%

Detection of Hodgkin lymphoma within ovarian tissue

Bittinger

Nazaretian

Gook

et al. 2011

Fertility and Sterility

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“…Several studies have suggested that ovarian tissue transplantation may be considered safe in case of HL [66][67][68], but one case report [69] showed ovarian involvement in stage III HL. The ovaries were also found to be affected by HL in 1-5 % of autopsies [70,71]. In some HL cases, large mediastinal masses may increase anesthetic risks and ovarian tissue harvesting may therefore be contraindicated.…”

Section: Hodgkin's Lymphomamentioning

confidence: 99%

Fertility considerations in young women with hematological malignancies

Jadoul

Kim

2012

J Assist Reprod Genet

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The need for practice guidelines for fertility preservation in young women with hematological malignancies has been increased. To develop recommendations, publications relevant to fertility preservation and hematological cancers were identified through a PubMed database search and reviewed systematically, focusing on the effects of oncological treatments on fertility as well as on the efficacy, feasibility and risks of existing fertility preservation methods.

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Visceral involvement in primary neoplastic diseases of the reticulo-endothelial system

Cited by 40 publications

References 26 publications

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases

Detection of Hodgkin lymphoma within ovarian tissue

Fertility considerations in young women with hematological malignancies

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