Detection of Hodgkin lymphoma within ovarian tissue

Management of fertility in patients treated for Hodgkin's lymphoma

“…A pelvic relapse has never been reported after ovarian implantation. 45 The other major drawback of the CPOT is the amputation of 50% of the ovarian reserve. There is, therefore, a risk of accelerating the process of POF, although how big a risk is not clear.…”

Detection of Non-Hodgkin’s Lymphoma in ovarian cortex pieces during the process of cryopreservation

“…To date, 15 auto-transplantations have been reported in HL patients and 6 in NHL without any disease recurrence, knowing that the follow-up after autotransplantation in one of the HL patients is now up to 8 years [19,[26][27][28][29][30][31][32][33][34]. Nevertheless, a recent case-report showed an ovarian involvement in the histologic examination of ovarian cortex pieces in a stage III HL [15]. The transvaginal ultrasonographic exam and the Positron Emission Tomography with 18 FDG performed before the surgery didn't detect any abnormality in this case.…”

“…To date, fifteen auto-transplantations have been performed for HL and six for NHL respectively without any disease recurrence [13]. Nevertheless, Bittinger et al recently showed an ovarian involvement of a stage III HL within the ovarian cortex pieces systematically assessed for the presence of tumor cells before storage [15]. We currently report the histological detection of NHL cells within the ovarian tissue removed for subsequent cryopreservation in a 24-year-old woman diagnosed with a Primary Mediastinal large B-cell Lymphoma.…”

Prevention of ovarian damage and infertility in young female cancer patients awaiting chemotherapy—clinical approach and unsolved issues

“…One case of a metastasis of Hodgkin's lymphoma in ovarian tissue harvested from a 19-year-old woman for cryopreservation was reported [61]. A high risk of ovarian metastasis is also reported for neuroblastoma [60], mainly occurring during childhood [62], and Burkitt lymphoma [45].…”