Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Zuo, Xiu Li; Li, Yan Qing; Shi, Lei; Lv, Guo Ping; Kuang, Rong Guang; Lu, Xue Feng; Li, Jun Man; Desmond, Paul

doi:10.1007/s00535-005-1766-x

Cited by 39 publications

(21 citation statements)

References 32 publications

(30 reference statements)

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“…Another less well‐established location of the 5‐HT 4 receptor in the human colon is on sensory nerve endings, where its function may be to increase sensory perceptions arising from the abdomen leading to altered motility patterns. Our recent clinical studies lend some support to this hypothesis and showed that IBS patients have significantly lower perception and defecation thresholds to rectal thermal and pressure stimuli compared to age‐ and gender‐matched control subjects 35–37 . 5‐HT 4 receptors also are present in the mucosa where they contribute to 5‐HT‐induced Cl − secretion 7 .…”

Section: Discussionmentioning

confidence: 61%

Distribution of serotonin receptors and interacting proteins in the human sigmoid colon

Chetty

Coupar

Tan

et al. 2009

Neurogastroenterology Motil

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This study aimed to examine the distribution of 5-HT receptors in the human colon. 5-HT induces desensitization of the circular muscle and as this is facilitated by G-protein coupled receptor kinases (GRKs) and other proteins, we also examined their distribution. Human sigmoid colon samples were dissected into three separate layers (mucosa, taeniae coli and intertaenial strips) and RNA was amplified by RT-PCR. The 5-HT(2B) receptor and all 5-HT(7) receptor splice variants were expressed in all tissues. 5-HT(4) a,b,c and n splice variants were also expressed in all tissues and 5-HT(4d), 5-HT(4g) and 5-HT(4i) were only detected in some samples. The 5-HT(2A) receptor was seen predominantly in the intertaenial strips of the colon. Only one transcript of the serotonin transporter (SERT) was detected in the muscle layers. Variation was seen in GRK expression with GRK2 and 3 predominantly expressed in the mucosa, while GRK5 and 6 were found more commonly in the taeniae coli. PDZ (named after postsynaptic density protein, Drosophila disc large tumour suppressor and tight junction protein ZO-1) domain containing proteins, which may be involved in 5-HT receptor trafficking, were also detected throughout the sigmoid colon. The 5-HT(3A) subunit was expressed in all tissues, whereas the 5-HT(3E) subunit was mainly found in the mucosa layer while the 5-HT(3B) subunit was more common in the muscle layers. Receptor interacting chaperone (RIC-3), which is involved in transporting 5-HT(3) receptor subunits, is expressed less in mucosa compared to muscle layers. In conclusion, these results show that there is variation in distribution of 5-HT receptors and interacting proteins within the sigmoid colon that may contribute to colonic function.

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Section: Discussionmentioning

confidence: 61%

Distribution of serotonin receptors and interacting proteins in the human sigmoid colon

Chetty

Coupar

Tan

et al. 2009

Neurogastroenterology Motil

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“…Dorn and Ersryd also reported IBS-D was the more prevalent subtype, followed by IBS-C [39], [40]. One reason may be that cold water intake may lead to lower visceral perception thresholds in Chinese IBS-D patients [41], [42]. Irregular intake of cold drinks is common in college and university students.…”

Section: Discussionmentioning

confidence: 97%

A School-Based Study with Rome III Criteria on the Prevalence of Functional Gastrointestinal Disorders in Chinese College and University Students

Dong

Chen

et al. 2013

PLoS ONE

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BackgroundFunctional gastrointestinal disorders, including functional dyspepsia, irritable bowel syndrome and functional constipation are very common worldwide.ObjectiveThis research aims to estimate the prevalence and associated factors involved in functional gastrointestinal disorders in Chinese college and university students using the Rome III criteria.MethodsA total of 5000 students from Shandong University in China were asked in January-May 2012 to complete questionnaires, including the Rome III questionnaire, hospital anxiety and depression scale, and negative life events scale.ResultsBased on the 4638 students who completed the questionnaire, the prevalence of functional dyspepsia, irritable bowel syndrome and functional constipation in college and university students of North China worked out to be 9.25%, 8.34% and 5.45% respectively. They were more frequent in female students. The factors of anxiety (OR 1.07; 95% CI 0.99 to 1.16, P = 0.002<0.05) and depression (OR 0.55; 95% CI 0.15 to 1.05, P = 0.045<0.05) indicated a high risk of causing irritable bowel syndrome.ConclusionFunctional dyspepsia, irritable bowel syndrome and functional constipation were common in college and university students of North China. Psychological disorders such as anxiety and depression provide significant risk factors for irritable bowel syndrome patients.

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“…To our knowledge, our work is the first study to use diverse methods, especially the ischemic sensitivity test, to examine somatic sensitivity in China. Unlike the cold sensitivity test which activates superficial Aδ fibers in the skin, the ischemic sensitivity test stimulates a large number of thick C-fibers in muscle and produces a deep and diffuse pain (Zuo et al, 2006;Zhou et al, 2010). In view of the above features, the ischemic sensitivity test may be more accurate for the evaluation of somatic sensitivity.…”

Section: Discussionmentioning

confidence: 99%

肠易激综合征亚型患者具有肠道和躯体高敏感, 自主心血管功能紊乱以及肠道低浓度炎症

Liu

Chen

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:The pathophysiology of irritable bowel syndrome (IBS) is complex and not fully understood, so the aim of this study was to evaluate whether visceral and somatic hypersensitivity, autonomic cardiovascular dysfunction, and low-grade inflammation of the gut wall are associated with diarrhea-predominant IBS (D-IBS). Sixty-two patients with D-IBS and 20 control subjects participated in the study. Using the ascending method of limits (AML) protocol, we demonstrated that D-IBS patients had significantly lower sensory thresholds compared with healthy controls (P<0.001). Using diverse methods, especially the ischemic sensitivity test, for the first time in China, we confirmed that D-IBS patients have somatic hypersensitivity. They had a significantly higher systolic blood pressure and heart rate after a cold stimulus, indicative of autonomic cardiovascular dysfunction. Compared with the control group, D-IBS patients had a significantly higher level of calprotectin (P<0.001). We also found significant correlations between visceral and somatic hypersensitivity, visceral hypersensitivity and autonomic cardiovascular dysfunction, and somatic hypersensitivity and autonomic cardiovascular dysfunction. Our findings may provide valuable suggestions for the treatment of D-IBS.

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Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome

Cited by 39 publications

References 32 publications

Distribution of serotonin receptors and interacting proteins in the human sigmoid colon

Distribution of serotonin receptors and interacting proteins in the human sigmoid colon

A School-Based Study with Rome III Criteria on the Prevalence of Functional Gastrointestinal Disorders in Chinese College and University Students

肠易激综合征亚型患者具有肠道和躯体高敏感, 自主心血管功能紊乱以及肠道低浓度炎症

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