Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients

Ho, Li-Chun; Yen, Chung‐Jen; Chao, Chia‐Ter; Chiang, Chih‐Kang; Huang, Jenq‐Wen; Hung, Kuan‐Yu

doi:10.1038/srep12811

Cited by 13 publications

(6 citation statements)

References 33 publications

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“…Age, BMI, HbA1c, use of RAS inhibitors, and serum creatinine level are independent determinants of visceral fat in non-diabetic PD patients. [ 15 ] In our study, the change in VFA showed a positive correlation with age and HDL-C, while it was negatively correlated with waist circumference and SFA. Also, there was no correlation between VFA and sex, BMI, HbA1c, serum creatinine, and RAS inhibitor usage.…”

Section: Discussionsupporting

confidence: 51%

Effect of long-term peritoneal dialysis on change in visceral fat area: A single-center experience

et al. 2020

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Introduction: Visceral fat area (VFA) is known to increase after initiation of peritoneal dialysis (PD). However, the factors contributing to the increase in VFA in long-term PD patients have not been sufficiently elucidated. The present study investigated factors that affect VFA in patients who continue PD for ≥3 years. Methods: Twenty patients (63.1 ± 10.3 years, 9 men, 11 diabetic patients) between January 2008 and January 2015 were included. VFA, subcutaneous fat area (SFA) and waist circumference at initiation and follow-up were measured at the level of the umbilicus by computed tomography using an image analysis system. Change in VFA was defined as the value obtained by dividing VFA at the final follow-up by that at the initiation. The correlations between clinical parameters at initiation and changes in VFA were analyzed. Results: There was no significant change in body weight (57.6 ± 10.4 vs 58.3 ± 7.8 kg, P = 0.296) during the mean final follow-up period of 55 ± 13 months, although VFA increased significantly (103.6 ± 39.2 vs 122.6 ± 38.3 cm 2 , P = 0.030). Although subcutaneous fat area (SFA) did not change (124.7 ± 52.3 vs 124.5 ± 49.2 cm 2 , P = 0.989), waist circumference increased significantly (79.4 ± 8.4 vs 83.7 ± 6.9 cm, P = 0.010). SFA (r = −0.735, P < 0.001), waist circumference (r = − 0.644, P = 0.002), high-density lipoprotein cholesterol (HDL-C) (r = 0.487, P = 0.029), and age (r = 0.507, P = 0.023) correlated significantly with changes in VFA. Conclusions: VFA might increase with long-term PD in patients with end-stage kidney disease who have high HDL-C, small SFA, and small waist circumference at initiation.

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Section: Discussionsupporting

confidence: 51%

Effect of long-term peritoneal dialysis on change in visceral fat area: A single-center experience

et al. 2020

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“…Therefore, smokers tended to be obese compared to non-smokers [ 26 ]. Moreover, a previous study revealed that visceral adiposity was associated with HbA1c [ 27 ]. We guess that these potential biological mechanisms are underlying the strong association between dual smoking and elevated HbA1c levels compared to non-smoking among obese people compared to normal and underweight people.…”

Section: Discussionmentioning

confidence: 99%

Association between Smoking Behavior Patterns and Glycated Hemoglobin Levels in a General Population

Choi

Jeon

Lee

et al. 2018

IJERPH

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This study investigated the association of smoking behaviors, including dual smoking (smoking both cigarettes and e-cigarettes), cigarettes smoking, and previous smoking, with glycated hemoglobin (HbA1c) levels. National Health and Nutrition Examination Survey (KNHANES) data from 2014–2016 was used. Associations between smoking behavior patterns and HbA1c levels were analyzed via multiple regression. Among 8809 participants, individuals who were dual smokers and cigarettes smokers had significantly higher HbA1c levels than non-smokers (dual: β = 0.1116, p = 0.0012, single: β = 0.0752, p = 0.0022). This relationship strengthened in subgroups of men (dual: β = 0.1290, p = 0.0013, single: β = 0.1020, p = 0.0014, ex: β = 0.0654, p = 0.0308), physically inactive subjects (dual: β = 0.1527, p = 0.0053, single: β = 0.0876, p = 0.0197), and overweight (dual: β = 0.1425, p = 0.0133) and obese individuals (dual: β = 0.1694, p = 0.0061, single: β = 0.1035, p = 0.0217). This study suggests that smoking behaviors are likely to increase the risk of HbA1c level in a general population. The health effects of dual smoking remain uncertain and should be addressed in the future.

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“…Some study results regarding echocardiography or laboratory data were published3334. The inclusion criteria for patients group in this study were 1) received PD for more than 6 months; 2) no history of cardiovascular disease such as atrial fibrillation, significant valvular heart disease, coronary artery disease, myocardial infarction, heart failure, cerebrovascular events, or peripheral artery disease.…”

Section: Methodsmentioning

confidence: 99%

Heart rhythm complexity impairment in patients undergoing peritoneal dialysis

Lin

et al. 2016

Sci Rep

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Cardiovascular disease is one of the leading causes of death in patients with advanced renal disease. The objective of this study was to investigate impairments in heart rhythm complexity in patients with end-stage renal disease. We prospectively analyzed 65 patients undergoing peritoneal dialysis (PD) without prior cardiovascular disease and 72 individuals with normal renal function as the control group. Heart rhythm analysis including complexity analysis by including detrended fractal analysis (DFA) and multiscale entropy (MSE) were performed. In linear analysis, the PD patients had a significantly lower standard deviation of normal RR intervals (SDRR) and percentage of absolute differences in normal RR intervals greater than 20 ms (pNN20). Of the nonlinear analysis indicators, scale 5, area under the MSE curve for scale 1 to 5 (area 1–5) and 6 to 20 (area 6–20) were significantly lower than those in the control group. In DFA anaylsis, both DFA α1 and DFA α2 were comparable in both groups. In receiver operating characteristic curve analysis, scale 5 had the greatest discriminatory power for two groups. In both net reclassification improvement model and integrated discrimination improvement models, MSE parameters significantly improved the discriminatory power of SDRR, pNN20, and pNN50. In conclusion, PD patients had worse cardiac complexity parameters. MSE parameters are useful to discriminate PD patients from patients with normal renal function.

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Visceral fat area is associated with HbA1c but not dialysate-related glucose load in nondiabetic PD patients

Cited by 13 publications

References 33 publications

Effect of long-term peritoneal dialysis on change in visceral fat area: A single-center experience

Effect of long-term peritoneal dialysis on change in visceral fat area: A single-center experience

Association between Smoking Behavior Patterns and Glycated Hemoglobin Levels in a General Population

Heart rhythm complexity impairment in patients undergoing peritoneal dialysis

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