Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances

Al-Daghri, Nasser M.; Al‐Attas, Omar S.; Alokail, Majed S.; Alkharfy, Khalid M.; Charalampidis, Paris; Livadas, Sarantis; Κόλλιας, Αναστάσιος; Sabico, Shaun; Chrousos, George P.

doi:10.1111/eci.12030

Cited by 77 publications

(59 citation statements)

References 26 publications

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“…In our study, the examined obesity measures showed consistent associations with age, blood pressure, adipokines, HOMA-IR, and CRP; however, there was a trend for superiority (stronger correlation coefficients and independent predictive value in multivariate analyses) for BMI (mainly) and WC relative to VAI and waist-hip ratio. VAI is independently associated with glucose values, a finding that has been reported from our group in a recent study in adults (22); however, this finding cannot establish its predictive value concerning the future emergence of impaired glucose tolerance and/or diabetes. On the other hand, BMI-an index of overall adiposity-was strongly associated with leptin values, which in turn demonstrated the strongest correlations with insulin resistance and subclinical inflammation.…”

Section: Discussioncontrasting

confidence: 55%

“…In addition, this index seems to have predictive value in terms of an increased risk for cardiovascular events (13) and has served as a marker of insulin resistance in several different nosologic entities (16)(17)(18)(19)(20)(21). Furthermore, our group recently reported, for the first time, the strong relationship of VAI with adipose tissue secretion and with functional glycemic disorders (22).…”

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confidence: 83%

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Does visceral adiposity index signify early metabolic risk in children and adolescents?: Association with insulin resistance, adipokines, and subclinical inflammation

et al. 2013

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Background: Visceral adiposity index (VAI) is a novel gender-specific index based on waist circumference (WC), BMI, and lipid parameters. Although VAI does not actually estimate visceral adiposity, it accurately reflects visceral fat function and insulin resistance. This index has not been studied in children thus far. This study aims to fill this gap. Methods: In a cohort of Saudi children and adolescents, anthropometric measurements and metabolic/hormonal profile were obtained. results: A total of 543 subjects, 292 of whom were boys, were included (mean age: 11.9 ± 3.3 y; BMI: 19.8 ± 5.6 kg/m 2 ). In all subjects, VAI was inferior to BMI and WC regarding its correlations with adiponectin, leptin, insulin resistance (homeostasis model of assessment-insulin resistance (HOMA-IR)), C-reactive protein (CRP) level, and systolic blood pressure, but it exhibited a stronger association with glucose in boys (r = 0.23; P < 0.01). In stepwise multivariate analyses, only BMI was consistent as an independent predictor of adiponectin, leptin, HOMA-IR, and CRP. VAI was the only index independently associated with glucose. conclusion: Although VAI is related to glucose in children, it seems to be inferior to BMI in terms of association with insulin resistance, adipokines, and subclinical inflammation. Until specific studies can be performed in children, VAI should be extrapolated with caution in this age range.

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confidence: 55%

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confidence: 83%

Does visceral adiposity index signify early metabolic risk in children and adolescents?: Association with insulin resistance, adipokines, and subclinical inflammation

et al. 2013

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“…However, despite this evidence, the VAI in CS has a strong application limit. The reason for this is that it is an indicator of early cardiometabolic risk and an important diagnostic tool in all borderline conditions in which overt MS is not present (32). Indeed, in our cohort of CS patients, 62.9% had overt MS, and so the VAI cannot be considered a specific index for these patients.…”

Section: Discussionmentioning

confidence: 88%

Is diabetes in Cushing's syndrome only a consequence of hypercortisolism?

Giordano

Guarnotta

Pivonello

et al. 2014

European Journal of Endocrinology

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Objective: Diabetes mellitus (DM) is one of the most frequent complications of Cushing's syndrome (CS). The aim of this study was to define the changes in insulin sensitivity and/or secretion in relation to glucose tolerance categories in newly diagnosed CS patients. Design: Cross-sectional study on 140 patients with CS. Methods: A total of 113 women (80 with pituitary disease and 33 with adrenal disease, aged 41.7G15.7 years) and 27 men (19 with pituitary disease and eight with adrenal disease, aged 38.1G20.01 years) at diagnosis were divided according to glucose tolerance into normal glucose tolerance (CS/NGT), impaired fasting glucose and/or impaired glucose tolerance (CS/prediabetes), and diabetes (CS/DM) groups. Results: Seventy-one patients had CS/NGT (49.3%), 26 (18.5%) had CS/prediabetes and 43 (30.8%) had CS/DM. Significant increasing trends in the prevalence of family history of diabetes (P!0.001), metabolic syndrome (P!0.001), age (P!0.001) and waist circumference (PZ0.043) and decreasing trends in HOMA-b (P!0.001) and oral disposition index (DIo) (P!0.002) were observed among the groups. No significant trends in fasting insulin levels, area under the curve for insulin (AUC INS ), Matsuda index of insulin sensitivity (ISI-Matsuda) and visceral adiposity index were detected. Conclusions: Impairment of glucose tolerance is characterized by the inability of b-cells to adequately compensate for insulin resistance through increased insulin secretion. Age, genetic predisposition and lifestyle, in combination with the duration and degree of hypercortisolism, strongly contribute to the impairment of glucose tolerance in patients with a natural history of CS. A careful phenotypic evaluation of glucose tolerance defects in patients with CS proves useful for the identification of those at a high risk of metabolic complications.

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“…Поэтому, в настоящее время предложены неинвазивные методы оценки выраженности висцераль-ного ожирения. Индикатором дисфункции жировой ткани при этом может являться расчетный индекс висцераль-ного ожирения [5,7,8], включающий антропометричес-кие (индекс массы тела и объем талии) и функциональ-ные (уровень триглицеридов и холестерина липопротеи-нов высокой плотности) показатели, свидетельствующие о распределении функции жировой ткани* [6].…”

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Visceral Obesity as a Risk Marker of Multiorgan Damage

Стаценко¹,

Туркина²,

Tyshchenko³

et al. 2017

Journal of VolgSMU

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Волгоградский государственный медицинский университетВ статье представлен обзор, посвященный взаимосвязи висцерального ожирения и формирования поражения сердца, почек, печени.Ключевые слова: висцеральное ожирение, сердечно-сосудистый риск, хроническая болезнь почек, неалкогольная жировая болезнь печени. VISCERAL OBESITY AS A RISK MARKER OF MULTIORGAN DAMAGEM. E. Statsenko, S. V. Turkinа, I. A. Tyshchenko, E. E. Gorbachevа, A. A. Ermolenko Volgograd State Medical UniversityThis article presents a review of the relationship between visceral obesity and the occurrence of damage to the heart, kidneys, liver.Key words: visceral obesity, cardiovascular risk, chronic kidney disease, non-alcoholic fatty liver disease.В настоящее время ожирение является одной из серьезных проблем современного общества и медици-ны. Распространенность ожирения существенно увели-чилась во всем мире, более чем 1,4 миллиарда взрос-лых и детей имеют повышенный индекс массы тела, из них 500 млн человек страдают ожирением. По данным Всемирной организации здравоохранения в 2014 г. бо-лее 1,9 миллиарда взрослых старше 18 лет имели избы-точный вес (38 % мужчин и 40 % женщин). Из них свы-ше 600 миллионов страдали ожирением (13 % всего взрослого населения планеты: 11 % мужчин и 15 % жен-щин). Таким образом, сделан вывод о том, что с 1980 по 2014 г. число людей, страдающих ожирением, во всем мире выросло более чем вдвое [46]. Безусловно, в раз-витии ожирения могут играть роль наследственные фак-торы [12], однако одной их главных причин такого «эпи-демиологического» роста заболевания является изме-нение образа жизни (избыточное поступление калорий, малоподвижный образ жизни), отсутствие понимания того, что ожирение является хроническим заболеванием, кото-рое при естественном течении активно прогрессирует [31]. При этом речь идет о роли висцерального ожирения и метаболически активной «висцеральной» жировой тка-ни (ЖТ). Ранее полагали, что основная роль жировой тка-ни заключается в отложении про запас энергии в форме триглицеридов и ее выделении в виде свободных жир-ных кислот в зависимости от потребностей организма. В настоящее время концепция биологической роли ЖТ кардинально изменилась, выделение ряда активных мо-лекул, секретируемых адипоцитами (лептина, резисти-на, адипонектина, стероидов, и т. д.) (рис. 1) манифести-ровало, что жировая ткань является сложным гормональ-но активным органом, играющим важнеqшую роль в ре-гуляции энергетического баланса и гомеостаза всего организма в целом.Рис. 1. Адипоцит как секреторная клетка [24]: ИАП -ингибитор активатора плазминогена-1, ТФР -трансформирующий фактор роста, ЛИФ -лейкоз-ингибирующий фактор, СЖК -свобод-ные жирные кислоты, ИЛ-6 -интерлейкин 6, ФНО- -фактор некроза опухоли  Топографические и функциональные особенности различных компартментов жировой ткани лежат в основе известных метаболических различий между висцераль-ным и глютео-феморальным типами ожирения (рис. 2) [30].

show abstract

Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances

Cited by 77 publications

References 26 publications

Does visceral adiposity index signify early metabolic risk in children and adolescents?: Association with insulin resistance, adipokines, and subclinical inflammation

Does visceral adiposity index signify early metabolic risk in children and adolescents?: Association with insulin resistance, adipokines, and subclinical inflammation

Is diabetes in Cushing's syndrome only a consequence of hypercortisolism?

Visceral Obesity as a Risk Marker of Multiorgan Damage

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