Visceral Adiposity and Insulin Resistance Increase the Risk of Breast Cancer: A Case-Control Study

Godinho-Mota, Jordana Carolina Marques; Martins, Karine Anusca; Vaz-Gonçalves, Larissa; Mota, João Felipe; Soares, Leonardo Ribeiro; Freitas‐Junior, Ruffo

doi:10.20960/nh.1441

Cited by 12 publications

(13 citation statements)

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“…Obesity is not correlated with breast cancer development before menopause, but hormone-positive breast cancer incidence increments every 5 years after menopause [ 103 ]. Moreover, central obesity is related to breast cancer development in pre-menopausal women [ 104 ], and it is especially related to the development of triple-negative breast cancer (TNBC) [ 105 , 106 , 107 ]. The mechanisms by which central obesity plays a role in breast cancer development are as follows: firstly, the NFκB, JAK, STAT3 and AKT pathways are activated by decreased adiponectin and increased leptin and estrogen in the leptin–adiponectin–estrogen axis; secondly, central adipose tissue induces oxidative stress by increasing the secretion of pro-inflammatory adipokines such as IL-1B, IL-6, IL-8 and TNFα; lastly, central adipose tissue increases the secretion of micro RNA (miR)s that play a role in cancer development, such as miR-23, miR-155, miR-140 and miR-302f, and decreases the secretion of miR-148b, a tumor suppressor miR (review [ 108 ]).…”

Section: Origin Of Adipokines In the Process Of Breast Cancer Bonementioning

confidence: 99%

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

Shin

Koo

2020

IJMS

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The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review.

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Section: Origin Of Adipokines In the Process Of Breast Cancer Bonementioning

confidence: 99%

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

Shin

Koo

2020

IJMS

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“…To our knowledge, no prospective studies investigating imagingbased body distribution related to breast cancer incidence or risk have been reported. Some support for the importance of VAT comes from a hospital-based case-control study with 116 incident breast cancer cases and 226 controls (23). A higher visceral adiposity index, predicted from waist circumference (WC), BMI, triglycerides, and highdensity lipoprotein, was associated with breast cancer (OR ¼ 1.91; 95% CI, 1.17-3.…”

Section: Discussionmentioning

confidence: 99%

Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study

Maskarinec

Ciba

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: As the stronger association of obesity with postmenopausal breast cancer in Asian than white women may be due to body fat distribution, we examined the relation of adiposity measures with percent mammographic density (PMD), a strong predictor of breast cancer incidence.Methods: A total of 938 women from five ethnic groups (69.1 AE 2.7 years) in the Adiposity Phenotype Study (APS) underwent DXA and MRI imaging. PMD was assessed in routine mammograms using a computer-assisted method. Spearman correlation coefficients were computed and general linear models were applied to estimate regression coefficients (b) for PMD per 0.5 SD units of adiposity measures while adjusting for known confounders, including DXA total body fat.Results: For 701 (75%) of the participants (69.1 AE 2.7 years), valid mammograms were obtained. Whereas total body fat, the trunk-to-periphery fat ratio (TPFR), visceral fat (VAT), and subcutaneous fat (SAT) were inversely correlated with PMD (P < 0.0001), the VAT/ SAT ratio correlated positively (r spearman ¼ 0.10; P ¼ 0.01). In fully adjusted models, PMD remained inversely related to TPFR and SAT and disappeared for VAT, while it was strengthened for VAT/SAT (b ¼ 0.51; P ¼ 0.009). This relation was stronger in Japanese Americans than other ethnic groups.Conclusions: This is the first study to show an association of a high VAT/SAT ratio with greater PMD, a marker of breast cancer risk after taking into account total body fat.Impact: The results indicate a link between the propensity to accumulate VAT and the amount of fat in the breast (1-PMD), which may influence the relation of obesity with breast cancer incidence.

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“…Central obesity has no connection with BC in post-menopausal women [12]. As follows, pre-menopausal women with increased central adiposity have a higher density of breast tissue [13], and an increased risk of developing triple-negative BC [14,15,16]. The C57BL/6 mice were induced in menopause by ovariectomy, subsequently given high-fat food, and injected with BC cells.…”

Section: Introductionmentioning

confidence: 99%

Molecular Links between Central Obesity and Breast Cancer

Zimța

Țigu

Muntean

et al. 2019

IJMS

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Worldwide, breast cancer (BC) is the most common malignancy in women, in regard to incidence and mortality. In recent years, the negative role of obesity during BC development and progression has been made abundantly clear in several studies. However, the distribution of body fat may be more important to analyze than the overall body weight. In our review of literature, we reported some key findings regarding the role of obesity in BC development, but focused more on central adiposity. Firstly, the adipose microenvironment in obese people bears many similarities with the tumor microenvironment, in respect to associated cellular composition, chronic low-grade inflammation, and high ratio of reactive oxygen species to antioxidants. Secondly, the adipose tissue functions as an endocrine organ, which in obese people produces a high level of tumor-promoting hormones, such as leptin and estrogen, and a low level of the tumor suppressor hormone, adiponectin. As follows, in BC this leads to the activation of oncogenic signaling pathways: NFκB, JAK, STAT3, AKT. Moreover, overall obesity, but especially central obesity, promotes a systemic and local low grade chronic inflammation that further stimulates the increase of tumor-promoting oxidative stress. Lastly, there is a constant exchange of information between BC cells and adipocytes, mediated especially by extracellular vesicles, and which changes the transcription profile of both cell types to an oncogenic one with the help of regulatory non-coding RNAs.

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Visceral Adiposity and Insulin Resistance Increase the Risk of Breast Cancer: A Case-Control Study

Abstract: visceral fat accumulation increases the risk of breast cancer.

Cited by 12 publications

References 0 publications

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis

Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study

Molecular Links between Central Obesity and Breast Cancer

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