Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice

Shin, Jeong-Ah; Jeong, Sae Im; Kim, Minsuk; Yoon, Jae-Cheol; Kim, Hee Sun; Park, Eun Mi

doi:10.1016/j.bbi.2015.07.008

Cited by 32 publications

(21 citation statements)

References 56 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 41 Specific cytokines including interleukin-1 and TNF-α have been heavily implicated in acute stroke patients, 27 , 42 and similar results have also been observed in ischemic brains of aged mice. 28 Vitamin D could reduce brain inflammation after brain injury. 43 …”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency is very common in stroke patients and has been related to the development of post-stroke depression. 27 , 28 Nevertheless, the effects of vitamin D on the incidence of PSA remain unclear. Therefore, we conducted this study to explore the potential association between serum levels of vitamin D and the development of PSA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety

Ren²,

Cheng³

et al. 2016

Medicine

View full text Add to dashboard Cite

Low levels of serum vitamin D are common in patients with mood disorders and stroke. It has been shown that low levels of serum vitamin D indicate a risk of depression in post-stroke subjects. Our aim was to determine the relationship between vitamin D and post-stroke anxiety (PSA).A consecutive series of 226 first acute ischemic stroke patients were recruited and followed up for 1 month. Serum levels of vitamin D were measured within 24 hours of admission. Patients with significant clinical symptoms of anxiety and a Hamilton anxiety scale score >7 were diagnosed as having PSA. In addition, 100 healthy subjects were recruited as controls and underwent measurements of serum vitamin D.A total of 60 patients (26.55%) showed anxiety at 1 month. Both PSA patients and non-PSA patients had lower serum levels of vitamin D than healthy subjects. A significant relationship was found between PSA and serum levels of vitamin D. Low serum levels of vitamin D (≤38.48 nmol/L) were independently associated with the development of PSA (OR: 2.49, 95% CI: 1.21–5.13, P = 0.01).Serum vitamin D status is related to the occurrence of anxiety in post-stroke patients and may be an independent risk factor of PSA after 1 month.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety

Ren²,

Cheng³

et al. 2016

Medicine

View full text Add to dashboard Cite

show abstract

“…While more expensive and surgically challenging, this is an increasingly important consideration as the response to stroke differs in young and aged animals [43,128,129]. Perhaps most importantly, aged animals have comorbidities that resemble those seen in clinical populations, including obesity [130] and hypertension. Thus, modeling stroke in aged animals allows for a more accurate modeling of stroke [127].…”

Section: The Role Of Aging On the Microglial Response To Brain Injmentioning

confidence: 99%

Old Maids: Aging and Its Impact on Microglia Function

Koellhoffer

McCullough

Ritzel

2017

IJMS

179

128

View full text Add to dashboard Cite

Microglia are highly active and vigilant housekeepers of the central nervous system that function to promote neuronal growth and activity. With advanced age, however, dysregulated inflammatory signaling and defects in phagocytosis impede their ability to perform the most essential of homeostatic functions, including immune surveillance and debris clearance. Microglial activation is one of the hallmarks of the aging brain and coincides with age-related neurodegeneration and cognitive decline. Age-associated microglial dysfunction leads to cellular senescence and can profoundly alter the response to sterile injuries and immune diseases, often resulting in maladaptive responses, chronic inflammation, and worsened outcomes after injury. Our knowledge of microglia aging and the factors that regulate age-related microglial dysfunction remain limited, as the majority of pre-clinical studies are performed in young animals, and human brain samples are difficult to obtain quickly post-mortem or in large numbers. This review outlines the impact of normal aging on microglial function, highlights the potential mechanisms underlying age-related changes in microglia, and discusses how aging can shape the recovery process following injury.

show abstract

“…The powerful immune system may be helpful in reducing and resolving neuroinflammation after anesthesia/surgery. In addition, Shin et al demonstrated that the BBB was damaged in aged mice, but not adult mice after anesthesia/surgery [27].…”

Section: Discussionmentioning

confidence: 99%

Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice

Zhou

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients. Numerous studies have demonstrated that multiple surgery/anesthesia during the neurodevelopmental period affects cognitive function, whereas a single anesthesia/surgery rarely causes cognitive dysfunction in adults. However, whether adults who undergo multiple anesthesia/surgery over a short period will experience cognitive dysfunction remains unclear. In this study, central nervous system inflammation and changes in cholinergic markers were investigated in adult mice subjected to multiple laparotomy procedures over a short period of time. The results showed that despite the increased expression of IL-6 and TNF-α in the hippocampus after multiple operations and the activation of microglia, multiple anesthesia/surgery did not cause a decline in cognitive function in adult mice. There were no changes in the cholinergic markers after multiple anesthesia/surgery.

show abstract

Visceral adipose tissue inflammation is associated with age-related brain changes and ischemic brain damage in aged mice

Cited by 32 publications

References 56 publications

Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety

Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety

Old Maids: Aging and Its Impact on Microglia Function

Multiple Anesthesia/Surgery Cannot Impair Reference Memory in Adult Mice

Contact Info

Product

Resources

About