Visceral abdominal adipose tissue and coronary atherosclerosis in asymptomatic diabetics

Khashper, Alla; Gaspar, Tamar; Azencot, Mali; Dobrecky‐Mery, Idit; Peled, Nathan; Lewis, Basil S.; Halon, David A.

doi:10.1016/j.ijcard.2011.05.059

Cited by 23 publications

(16 citation statements)

References 28 publications

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“…Furthermore, the VFA/SFA may reflect the balance of the atherogenic effect of VFA and the anti-atherogenic effect of SFA [2,3]. Narumi H. et al also suggested that the VFA/SFA ratio is a better predictor of the marker for atherosclerosis, CSWA, as compared with SFA or VFA [3], which is in agreement with a significant association between the VFA/SFA ratio and baPWV in present study.…”

supporting

confidence: 91%

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Katsuyama

Kawaguchi

Yanai

2015

International Journal of Cardiology

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supporting

confidence: 91%

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Katsuyama

Kawaguchi

Yanai

2015

International Journal of Cardiology

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“…Some previous studies have shown associations between increases in liver enzymes and the presence of CAC (25), or between liver fat, measured by ultrasound or CT, and CAC (26–28). In contrast, other investigators have failed to find independent associations between measures of liver fat and CAC (29,30). This study extends previous work by including people without diabetes and including assessment of the effects of both IR and fatty liver as a marker of NAFLD.…”

Section: Discussionmentioning

confidence: 79%

Fatty Liver, Insulin Resistance, and Features of Metabolic Syndrome

et al. 2012

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OBJECTIVENonalcoholic fatty liver disease (NAFLD) coexists with insulin resistance (IR), but it is uncertain whether NAFLD and IR contribute independently to atherosclerosis. We tested whether fatty liver, IR, and metabolic syndrome (MetS) features (waist, glucose, triglyceride, HDL cholesterol [HDL-C], and blood pressure) were associated with a marker of atherosclerosis (coronary artery calcium [CAC] score >0), independently of cardiovascular risk factors and cardiovascular disease (CVD).RESEARCH DESIGN AND METHODSData were analyzed from a South Korean occupational cohort of 10,153 people who all received ultrasound measurements of fatty liver and a cardiac computed tomography CAC score. IR was defined by homeostasis model assessment of IR (HOMA-IR) ≥75th percentile. Odds ratios (ORs) (95% CIs) for the presence of a CAC score >0 were estimated using logistic regression.RESULTSThere were 915 people with a CAC score >0. MetS features were increased (glucose, blood pressure, triglyceride, and waist) or decreased (HDL-C) among people with a CAC score >0 (all comparisons against CAC score ≤0; P < 0.0001). Of subjects with a CAC score >0, 55% had fatty liver and 33.7% were insulin resistant. Fatty liver (OR 1.21 [95% CI 1.01–1.45]; P = 0.04) and HOMA-IR (1.10 [1.02–1.18]; P = 0.02) were associated with CAC score >0, independently of all MetS features, conventional cardiovascular risk factors, and prior evidence of CVD. The presence of IR and fatty liver combined was associated with CAC score >0 (1.53 [1.20–1.95]; P = 0.001).CONCLUSIONSFatty liver and HOMA-IR are both associated with a CAC score >0 (independently of each other), features of MetS, conventional cardiovascular risk factors, and existing CVD.

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“…Some reports suggest that insulin resistance, cardiovascular events and MetS are not influenced by subcutaneous fat . Conversely, some studies have suggested the biological importance of subcutaneous fat and several studies have shown the anti‐atherogenic effect of subcutaneous fat . The effect of subcutaneous fat on urinary stone formation remains poorly understood and further studies are required to elucidate the relationship between subcutaneous fat and urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

et al. 2018

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Visceral abdominal adipose tissue and coronary atherosclerosis in asymptomatic diabetics

Cited by 23 publications

References 28 publications

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Fatty Liver, Insulin Resistance, and Features of Metabolic Syndrome

Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

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