Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Katsuyama, Hisayuki; Kawaguchi, Akiko; Yanai, Hidekatsu

doi:10.1016/j.ijcard.2014.10.112

Cited by 19 publications

(13 citation statements)

References 4 publications

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“…On the other hand, VFAR or the ratio of visceral to subcutaneous fat area at the umbilical level, has received attention as a more significant risk factor for MetS‐related diseases in recent years. These include atherosclerosis and erectile dysfunction . In addition, VFV was reported to be a more appropriate indicator of visceral obesity because the maximal VFA was not at the umbilicus but was widely distributed from L1 to L5 .…”

Section: Discussionmentioning

confidence: 99%

“…These include atherosclerosis and erectile dysfunction. 3,13 In addition, VFV was reported to be a more appropriate indicator of visceral obesity because the maximal VFA was not at the umbilicus but was widely distributed from L1 to L5. 5,14,15 However, to our knowledge, few studies have been conducted to evaluate the association of urinary stone disease and the various fat parameters described above.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

et al. 2018

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“…In the survey of 3,223 participants from the Framingham Heart Study, a higher V/S ratio was significantly associated with cardiovascular risk factors including blood pressure, dyslipidemia and insulin resistance independently of BMI. Katsuyama et al . reported in a cross‐sectional study comprising obese participants that the V/S ratio was significantly and positively associated with fasting triglyceride levels and brachial‐ankle pulse wave velocity, a marker of arterial stiffness, but VFA was not associated with brachial‐ankle pulse wave velocity.…”

Section: Discussionmentioning

confidence: 99%

“…Considering independent effects of both visceral and subcutaneous fat on cardiometabolic risks and CVD, the relative distribution of body fat might be more important than visceral fat area (VFA) or subcutaneous fat area (SFA) per se. Actually, the ratio of VFA to SFA (V/S ratio) has been reported to be more strongly associated with cardiometabolic risks than VFA [17][18][19][20] . Narumi et al 20 proposed that the V/S ratio is a better predictor of the calcium score of the whole aorta, as a marker of atherosclerosis, than SFA or VFA.…”

Section: Introductionmentioning

confidence: 99%

Ratio of visceral‐to‐subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes

Fukuda

Bouchi

Takeuchi

et al. 2017

J of Diabetes Invest

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Aims/IntroductionTo investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA; V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes.Materials and MethodsA total of 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% women) were enrolled. VFA (cm2) and SFA (cm2) were assessed by a dual bioelectrical impedance analyzer. The patients were divided into four groups according to the quartiles of the V/S ratio. The study end‐point was the first occurrence or recurrence of CVD.ResultsOver a median follow up of 2.5 years, 21 patients reached the end‐point. The number of patients who reached the end‐point was increased along with the increasing of the V/S ratio quartiles. The V/S ratio was significantly associated with incident or recurrent CVD (hazard ratio [HR] 1.82, 95% CI: 1.09–3.04, P = 0.021) after adjusting for estimated glomerular filtration rate (HR 0.98, 95% CI: 0.96–1.00), brain‐type natriuretic peptide (HR 1.00, 95% CI: 1.00–1.01), use of antiplatelet agents (HR 4.26, 95% CI: 1.63–11.13), coefficient of variation of R‐R intervals (HR 0.85, 95% CI: 0.69–1.10) and glycated hemoglobin (HR 1.37, 95% CI: 1.05–1.79). The addition of the V/S ratio to age, estimated glomerular filtration rate, brain‐type natriuretic peptide, antiplatelet agents and glycated hemoglobin significantly improved classification performance for CVD using net reclassification improvement (0.60, 95% CI: 0.21–1.00) and the integrated discrimination improvement (0.02, 95% CI: 0.00–0.05).ConclusionsThe V/S ratio measured by dual bioelectrical impedance analyzer is an independent predictor of CVD in patients with type 2 diabetes.

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“…Recently, we reported that the associations of VFA and the VFA/SFA ratio to metabolic parameters in obese Japanese subjects with pre-diabetes [9]. The participants were patients without overt diabetes (12 men and 17 women).…”

Section: Discussionmentioning

confidence: 99%

Correlations of Body Mass Index, Japan-Defined and IDF-Defined Waist Circumference, Visceral and Subcutaneous Fat Area with Metabolic Parameters in Japanese Patients with Type 2 Diabetes

Yanai¹,

Hirowatari²

2015

JDM

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Obesity is included in the definition of metabolic syndrome. However, there are many controversies surrounding the evaluation of obesity such as body mass index (BMI) and waist circumference (WC) in the definition of metabolic syndrome among various populations. To understand precisely how various anthropometric indices of obesity influence metabolic parameters, we studied the correlations of BMI, WC (Japanese criteria), WC (IDF criteria), visceral fat area (VFA), subcutaneous fat area (SFA) and the VFA/SFA ratio with metabolic parameters in patients with type 2 diabetes. The influences of BMI and WC on diastolic blood pressure and HDL-cholesterol were larger than VFA, whereas the influences of visceral fat area on triglyceride, very low-density lipoprotein-cholesterol, C-peptide and high-sensitivity C-reactive protein were larger than BMI and WC. WC (IDF) was the strongest determinant of adiponectin among anthropometric indices. Present study showed significant different associations of BMI, Japan-and IDF-defined WC, VFA, SFA and the VFA/SFA ratio with blood pressure, glucose and lipid metabolism, and adipocytokines in Japanese patients with type 2 diabetes.

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Not visceral fat area but the ratio of visceral to subcutaneous fat area is significantly correlated with the marker for atherosclerosis in obese subjects

Cited by 19 publications

References 4 publications

Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

Recurrent stone‐forming patients have high visceral fat ratio based on computed tomography images compared to first‐time stone‐forming patients

Ratio of visceral‐to‐subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes

Correlations of Body Mass Index, Japan-Defined and IDF-Defined Waist Circumference, Visceral and Subcutaneous Fat Area with Metabolic Parameters in Japanese Patients with Type 2 Diabetes

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