Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin

Singh, Rhea; Freeman, Esther E.

doi:10.1007/s13671-022-00370-9

Cited by 6 publications

(9 citation statements)

References 171 publications

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“…The landscape of cutaneous presentations Is likely to evolve due to novel variants of the virus, as demonstrated for the SARS-CoV-2 Omicron variant [101], and long COVID syndrome [102]. The published evidence suggests that long COVID patients, even those who experienced less severe or even asymptomatic diseases, may have a prolonged inflammatory response [103], probably coupled with viral reactivation and/or immune dysregulation able to prevent the resolution of cutaneous manifestations [104].…”

Section: Cutaneous Manifestationsmentioning

confidence: 99%

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Calcaterra,

Zanelli,

Foppiani

et al. 2024

Diseases

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Long COVID affects both children and adults, including subjects who experienced severe, mild, or even asymptomatic SARS-CoV-2 infection. We have provided a comprehensive overview of the incidence, clinical characteristics, risk factors, and outcomes of persistent COVID-19 symptoms in both children and adults, encompassing vulnerable populations, such as pregnant women and oncological patients. Our objective is to emphasize the critical significance of adopting an integrated approach for the early detection and appropriate management of long COVID. The incidence and severity of long COVID symptoms can have a significant impact on the quality of life of patients and the course of disease in the case of pre-existing pathologies. Particularly, in fragile and vulnerable patients, the presence of PASC is related to significantly worse survival, independent from pre-existing vulnerabilities and treatment. It is important try to achieve an early recognition and management. Various mechanisms are implicated, resulting in a wide range of clinical presentations. Understanding the specific mechanisms and risk factors involved in long COVID is crucial for tailoring effective interventions and support strategies. Management approaches involve comprehensive biopsychosocial assessments and treatment of symptoms and comorbidities, such as autonomic dysfunction, as well as multidisciplinary rehabilitation. The overall course of long COVID is one of gradual improvement, with recovery observed in the majority, though not all, of patients. As the research on long-COVID continues to evolve, ongoing studies are likely to shed more light on the intricate relationship between chronic diseases, such as oncological status, cardiovascular diseases, psychiatric disorders, and the persistent effects of SARS-CoV-2 infection. This information could guide healthcare providers, researchers, and policymakers in developing targeted interventions.

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Section: Cutaneous Manifestationsmentioning

confidence: 99%

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Calcaterra,

Zanelli,

Foppiani

et al. 2024

Diseases

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“…More than 30 different skin eruptions caused by COVID-19 virus have been described [159] and the characteristics manifestation of these dermatological conditions varies between individuals [117,118]. For instance, urticaria with itchy welts on the skin could be presented jointly with other COVID-19 symptoms [111,112].…”

Section: Long Covid-19 and Dermatological Complicationsmentioning

confidence: 99%

“…However, perniosiform lesions were pointed out as the most evaluated lesions in the long term [119]. It also needs to be noted that as novel virus variants arise, new cutaneous patterns will be expected in long COVID-19 syndrome [159]. The summary of dermatological complications can be seen in Table 1.…”

Section: Long Covid-19 and Dermatological Complicationsmentioning

confidence: 99%

The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems

Golzardi,

Hromić-Jahjefendić,

Šutković

et al. 2024

Preprint

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Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions of people all over the world. Previous studies have shown that PASC impacts 10% of SARS-CoV-2 infected patients of which 50-70% are hospitalized. It has also been shown that 10-12% of those vaccinated against COVID-19 were affected with PASC and its complications. The severity and the later development of PASC symptoms is positively associated with the early intensity of the infection. Results: The generated health complications caused by PASC involve a vast variety of organ systems. Patients affected by PASC have been diagnosed with neuropsychiatric and neurological symptoms. Cardiovascular system also has been involved and several diseases such as myocarditis, pericarditis, and coronary artery diseases were reported. Chronic hematological problems such as thrombotic endothelialitis and hypercoagulability were described as a condition that could increase the risk of clotting disorders and coagulopathy in PASC patients. Chest pain, breathlessness, and cough in PASC patients were associated with respiratory system in long COVID-19 causing respiratory distress syndrome. The observed immune complications were notable, involving several diseases. Renal system also was impacted and result in raising the risk of diseases such as thrombotic issues, fibrosis, and sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, and male infertility. Symptoms such as diarrhea, nausea, loss of appetite and taste were also among reported observations due to several gastrointestinal disorders. Skin abnormalities might be an indication of infection and long-term implications such as persistent cutaneous complaints were linked to PASC. Conclusions: Long COVID is a multidimensional syndrome with considerable public health implications, affecting several physiological systems and demanding thorough medical therapy as well as more study to address its underlying causes and long-term effects.

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“…Erythema multiforme (EM)-like lesions, multisystem inflammatory syndrome in adults (MIS-A), and multisystem inflammatory syndrome in children (MIS-C) have also been reported, albeit more rarely. Skin manifestations associated with COVID-19 was observed not only as a symptom of infection but also in relation to vaccines (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers

Kartal,

Orujova,

Ertaş

2023

Front. Med.

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BackgroundThe relationship between CSU and vaccines is reported in the literature. The post-vaccine clinical effect of COVİD-19 vaccines on CSU patients is still unclear. we aimed to evaluate clinical effects of COVID-19 Vaccines on CSU patients.Materials and methodsCSU patients under treatment and follow-up in our outpatient clinic were evaluated retrospectively. To determine disease activity the urticaria activity score over seven days (UAS7) was used. The details of demographic information, CSU treatment, history of COVID-19 infection and exacerbation of urticaria during infection, COVID-19 vaccinations, type of vaccine, side effect reaction time after vaccination, hospital admission requirement were also assessed.ResultsTotal of 190 patients with a mean age of The mean age of patients was 41,7±14,0 years (range = 18–72) were enrooled. The patient sample consisted of 50 males and 140 females (male/female ratio 1:2.8). 181 (CoronaVac 77, Pfizer-BioNTech 104) patients were vaccinated. Urticarial exacerbation was occurred in 25 patients. The median UAS value was 5 before vaccination, it was 12 in patients with post-vaccine urticaria. Two patients had angioedema and one patient had anaphylaxis after vaccinated with Pfizer-BioNTech.ConclusionCOVID-19 vaccination in the CSU can be considered safe. Cases with urticarial exacerbation appear to be transient and can be managed by antihistamine and/or systemic steroid therapies. More extensive studies are needed for the relationship with CSU and post-coronavirus vaccination anaphylaxy.

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Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin

Cited by 6 publications

References 171 publications

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

Long COVID in Children, Adults, and Vulnerable Populations: A Comprehensive Overview for an Integrated Approach

The Aftermath of COVID-19: Exploring Long-Term Effects on the Organ Systems

Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers

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