Virus Particles in Hamster Tumors as Revealed by Electron Microscopy.

Stenback, Wayne A.; Hoosier, G. L. Van; Trentin, John J.

doi:10.3181/00379727-122-31365

Cited by 35 publications

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“…1, 2) and thymus (Fig. 3) form by viral genetic material incorporated in the cell but which does not regularly complete a maturational cycle culminating in a morphologically recognizable entity, as in certain virusinduced hamster tumors (Ahlstrom et al, 1963;Stenback et al, 1966;Huebner et a/., 1966); or (b) chemotherapeutic agents applied clinically suppress the synthesis of virus particles (Sidwell et al, 1966;Chirigos and March, 1966). Recently, Huebner and Todaro (1969) have hypothesized, on the basis of their experiments with the type-C RNA viruses associated with the murine and avian neoplasms, that " cells of most or all vertebrate species have C-type RNA virus genomes that are vertically transmitted from parent to offspring" and from one cell to the progeny cell.…”

Section: Figure Imentioning

confidence: 99%

Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues in vivo and in vitro

Chandra

Liszczak

Korol

et al. 1970

Intl Journal of Cancer

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Thirty‐two early‐passage human embryonic cultures were examined in the electron microscope and one of them, derived from a muscle tissue, contained two budding and four mature type‐C virus particles. Of the 15 original embryonic tissues from five embryos, only one showed the presence of a virus‐like particle. It is of interest to note that the tissue specimens which contained virus‐like particles originated from the same embryo.

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Section: Figure Imentioning

confidence: 99%

Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues in vivo and in vitro

Chandra

Liszczak

Korol

et al. 1970

Intl Journal of Cancer

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“…A possible mechanism would be activation of enzootic agents, e.g., the hamster type A or C viruses (9,10,11). The type C virus particle from tumor-bearing hamsters from our colony was found to contain an antigen (MuLV-gs 3 ) in common with murine and feline leukemia viruses (L. J.…”

mentioning

confidence: 99%

Oncogenic Evaluation in Hamsters of Human Picorna-, Paramyxo-, and Herpesviruses

Trentin

Hoosier

Ferguson

et al. 1969

Experimental Biology and Medicine

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“…Dans toutes les lignees examinees ont Cte observees des particules de type R. Ces particules, decrites exclusivement dans des tumeurs du hamster syrien (Stenback et al, 1966;Lindberg, 1969) representent vraisemblablement un virus latent de cette espece. Une Ctude quantitative serait interessante afin d'ktablir s'il existe une relation entre le nombre de particules R et la tumorigCnicitC des cellules correspondantes.…”

Section: Discussionunclassified

Recherche de particules virales dans des lignées cellulaires de hamster transformées par le virus de rous investigations on the presence of viral particles in rous transformed hamster cell lines

Gazzolo

1971

Intl Journal of Cancer

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In the framework of a study on the recovery of the Rous Sarcoma Virus ( R S V ) from transformed mammalian cells, nine Syrian hamster cell-lines transformed by RSV were examined by electron microscopy. Six of these lines were obtained from BHK 211Clone 13 cells transformed in vitro by RSV, either Schmidt-Ruppin strain (SR-RSV) or Bryan strain (B-RSV), one of them being supertransformed by polyoma virus. Another line ( R S H ) was obtained from embryonic hamster cells transformed in vitro by SR-RSV. Two lines resulted from in vivo experiments: SRICI, was obtained from a SR-RSV-induced tumour in a Syrian hamster; and RS,-TH2 represented an in vitro cultured tumour obtained in a Syrian hamster by the inoculation of RS2 cells transformed in vitro by SR-RSV. All these lines had the group-specific antigen ( G S ) and it was possible to rescue RSV from all lines except SRICI, when they were cultivated in association with permissive chick cells. No C-type virus particles could be observed either in the six lines transformed in vitro or in two lines ( R S H and SRICI,) transformed in vitro.On the contrary, the line RS2-TH, contained C-type particles, morphologically similar to murine leukemia virus, and probably representing a latent hamster virus. In line SRICI,, A-type particles were found associated with mitochondria. The significance of the presence of these particles in this only non-virogenic line is discussed. Finally, in all the hamster lines examined, R-type particles were observed. They were more numerous in the in vivo transformed lines than in the in vitro transformed lines.

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Virus Particles in Hamster Tumors as Revealed by Electron Microscopy.

Cited by 35 publications

References 0 publications

Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues in vivo and in vitro

Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues in vivo and in vitro

Oncogenic Evaluation in Hamsters of Human Picorna-, Paramyxo-, and Herpesviruses

Recherche de particules virales dans des lignées cellulaires de hamster transformées par le virus de rous investigations on the presence of viral particles in rous transformed hamster cell lines

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