Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues <i>in vivo</i> and <i>in vitro</i>

Chandra, S.; Liszczak, Theodore M.; Korol, W.; Jensen, Elizabeth

doi:10.1002/ijc.2910060107

Cited by 19 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Viruses and viral antigens have been found in normal as well as aberrant tissues [19][20][21]. Therefore, the mere presence of infectious agents does not suggest an etiology.…”

Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

View full text Add to dashboard Cite

Mumps virus antigens were demonstrated in biopsied tissues from Hodgkin’s disease patients by indirect immunofluorescence. Impression smears from ten lymph node and two spleen specimens revealed viral antigens in the nucleus, cytoplasm or both. Measles virus antigens were detected in six out of seven Hodgkin’s disease tissues (lymph nodes) both in the nucleus and cytoplasm. All tissues tested for the presence of Newcastle diesease virus (NDV, an avian paramyxovirus) antigens were negative. Control tissues were obtained from patients with non-Hodgkin’s lymphomas, breast cancers, adenocarcinomas and a number of other disease processes. In control tissues mumps antigens were detected in seven out of 31 specimens and measles antigens in nine out of 18 tissues.

show abstract

“…Viruses and viral antigens have been found in normal as well as aberrant tissues [19][20][21]. Therefore, the mere presence of infectious agents does not suggest an etiology.…”

Section: Discussionmentioning

confidence: 99%

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Truant¹,

Hallum²

1976

Oncology

View full text Add to dashboard Cite

show abstract

“…Virus particles were consistently seen at sites opposite the microvilli, usually in areas of convoluted plasma membrane (X 13,000). 6. Several C-type particles and various pleomorphic structures within an intracytoplasmic vesicle (x 78,000).…”

mentioning

confidence: 99%

“…calltion must be exercised in interpretinig these observations, particuLlarly becaulse of the polymorphic nature of the LIltra-strLuctLiral aspects of the trophoblast. Chandra et al (6) Abstract. Mitotic chromosomes of rat kanigaroo cells were irradiated with a greeni argoon laser mnicrobeamn without prior dlye senisitizationi.…”

mentioning

confidence: 99%

Observations of Apparent C-Type Particles in Baboon ( Papio cynocephalus ) Placentas

Kalter

Helmke

Panigel

et al. 1973

Science

112

View full text Add to dashboard Cite

show abstract

“…Its relevance to epidemiological studies of familial neoplastic diseases in man is obvious. This is perhaps especially true now that we have become aware of the variety and extent of vertically transmitted viral material in many species including our own (Chandra et al, 1970;Kalter et at., 1973Kalter et at., , 1975Rongey et al, 1973). The literature on the epidemiological implications of vertical transmission is growing rapidly, not only with reference to oncornaviruses, but also to such agents as cytomegalovirus (for example, Namazaki et al, 1970).…”

Section: Discussionmentioning

confidence: 98%

Analysis of family history data for evidence of non-Mendelian inheritance resulting from vertical transmission.

Fine¹

1977

Journal of Medical Genetics

View full text Add to dashboard Cite

SUMMARY A number of infections of man, as well as of other animal and plant species, are heavily dependent upon 'vertical transmission'-that is direct parent-to-progeny transfer-for their maintenance in host populations. Such vertical transmission may be considered as a form of inheritance. It is usually non-Mendelian. This paper discusses the implications of such inheritance for the distribution of disease in families. A method is described for making quantitative predictions of prevalence rates of infection and of disease within different classes of relatives of either infected or uninfected probands. It is pointed out that, whereas a maternal line excess is to be expected among relatives of positive probands, the opposite should be found in families ofnegative probands. Expected differences between maternal and paternal line prevalence rates of observable disease decline rapidly with distance of relationship from the proband, and are greatly reduced by diagnostic insensitivity (analogous to penetrance). The implications of this analytic method for the design of family history studies are discussed. Published data on familial breast cancer are reviewed, and found to show no evidence that this condition is associated with a non-integrated vertically transmitted agent.

show abstract

Type‐C particles in human tissues. I. Electron microscopic study of embryonic tissues in vivo and in vitro

Cited by 19 publications

References 13 publications

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Detection of Mumps Virus Antigens in Hodgkin’s Disease Tissues

Observations of Apparent C-Type Particles in Baboon ( Papio cynocephalus ) Placentas

Analysis of family history data for evidence of non-Mendelian inheritance resulting from vertical transmission.

Contact Info

Product

Resources

About