Virus Particles in Cultured Lymphoblasts From Burkitt's Lymphoma

The Behaviour and Morphology of a Second Tissue Culture Strain (EB2) of Lymphoblasts from Burkitt's Lymphoma

“…The EB2 cells can therefore be considered as a more primitive example of Burkitt tumour lymphoblasts, but like the closely-related EBI strain, they would appear to be derived from the malignant elements of the tumour since they possess, though less frequently, annulate lamellae (Fig. 14) which in mammals are a feature either of developing germ cells (Palade, 1956;Swift, 1956) or of undifferentiated malignanit cells (Epstein, 1957 ; Wessel and Bernhard, 1957Epstein, 1961Chambers anid Weiser, 1964).…”

Epstein-Barr virus–associated lymphoproliferative disorders

“…Epstein-Barr virus (EBV), a member of the human herpesvirus family, is a linear, double-stranded DNA virus that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964 [1]. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis [2].…”

Epstein–Barr virus-associated adenocarcinomas and squamous-cell lung carcinomas

“…2 Among the environmental carcinogenetic agents, some viruses have been closely linked with many human cancers. The Epstein-Barr virus (EBV) was the first to be accepted as a human tumour virus associated with Burkitt's lymphoma, 3 and since then, EBV has been correlated with other specific malignancies as Hodgkin's disease, B-cell lymphomas in immunosuppressed individuals and a variety of undifferentiated carcinomas (the so-called lymphoepitheliomas), especially those occurring in the nasopharynx and foregut-derived organs. 4 In the case of the lung, the last WHO classification of pulmonary neoplasms has classified lymphoepithelioma-like carcinoma as a large-cell carcinoma variant.…”