Virus Maturation

Martín, Carmen San

doi:10.1007/978-3-030-14741-9_7

Cited by 7 publications

(2 citation statements)

References 190 publications

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“…In brief, dengue virus infectivity depends on the ability of envelope proteins to target cell heparan sulfates . The surfaces relevant for the interactions with HS are presumably hidden in the immature dengue virus conformations, which undergo conformational changes to become infectious, allowing them to move between vector and host, and/or infected and healthy cells. − While the usage of VLPs is highly convenient for safety reasons, we do acknowledge some limitations. For instance, initially our dengue VLP samples contained a high percentage of immature particles which did not bind to our HS-functionalized shells.…”

Section: Resultsmentioning

confidence: 99%

Broad-Spectrum Virus Trapping with Heparan Sulfate-Modified DNA Origami Shells

et al. 2022

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Effective broadband antiviral platforms that can act on existing viruses and viruses yet to emerge are not available, creating a need to explore treatment strategies beyond the trodden paths. Here, we report virus-encapsulating DNA origami shells that achieve broadband virus trapping properties by exploiting avidity and a widespread background affinity of viruses to heparan sulfate proteoglycans (HSPG). With a calibrated density of heparin and heparan sulfate (HS) derivatives crafted to the interior of DNA origami shells, we could encapsulate adeno, adeno-associated, chikungunya, dengue, human papilloma, noro, polio, rubella, and SARS-CoV-2 viruses or virus-like particles, in one and the same HSfunctionalized shell system. Additional virus-type-specific binders were not needed for the trapping. Depending on the relative dimensions of shell to virus particles, multiple virus particles may be trapped per shell, and multiple shells can cover the surface of clusters of virus particles. The steric occlusion provided by the heparan sulfate-coated DNA origami shells can prevent viruses from further interactions with receptors, possibly including those found on cell surfaces.

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Section: Resultsmentioning

confidence: 99%

Broad-Spectrum Virus Trapping with Heparan Sulfate-Modified DNA Origami Shells

et al. 2022

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“…Viruses are a unique class of infectious, obligate intracellular parasites whose genetic material is composed of either DNA or RNA [1]. The virus particle itself is composed of a nucleocapsid, which contains the genome with the ability to replicate and a protein shell [2]. In the case of enveloped viruses, the nucleocapsid is surrounded by a lipid membrane resembling that of the host cell, which is studded with spike structures.…”

Section: Introductionmentioning

confidence: 99%

Utilizing Electrochemical Biosensors as an Innovative Platform for the Rapid and On-Site Detection of Animal Viruses

He,

Wang,

et al. 2023

Animals

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Animal viruses are a significant threat to animal health and are easily spread across the globe with the rise of globalization. The limitations in diagnosing and treating animal virus infections have made the transmission of diseases and animal deaths unpredictable. Therefore, early diagnosis of animal virus infections is crucial to prevent the spread of diseases and reduce economic losses. To address the need for rapid diagnosis, electrochemical sensors have emerged as promising tools. Electrochemical methods present numerous benefits, including heightened sensitivity and selectivity, affordability, ease of use, portability, and rapid analysis, making them suitable for real-time virus detection. This paper focuses on the construction of electrochemical biosensors, as well as promising biosensor models, and expounds its advantages in virus detection, which is a promising research direction.

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Adenoviruses – Infection, pathogenesis and therapy

Greber

2020

FEBS Letters

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Both well-known and emerging viruses increasingly affect humans and cause disease, sometimes with devastating impact on society. The viruses present in the biosphere are the top predators in the life chain, virtually without enemies, except perhaps the immune system, and harsh environmental physicochemical conditions restricting their dissemination. We know a lot about viruses, but do we know enough? This series of reviews is dedicated to adenoviruses (AdVs), a family of nonenveloped DNA viruses occurring in vertebrates, including humans. AdVs have been the focus of intense research for more than 67 years. Besides causing disease, they have immensely contributed to the advance of life sciences and medicine over the past decades. Recently, AdVs have been widely used as vehicles in gene therapy and vaccination. They continue to provide fundamental insights into virus-host interactions in cells, tissues and organisms, as well as systems and metabolic networks. This special issue of FEBS Letters presents a unique collection of 23 state-of-theart review articles by leading adenovirologists. In this prelude, I present the chapters, which provide a solid basis for further exploring the rich heritage in adenovirus molecular cell biology, structural biology, genetics, immunology, gene therapy and epidemiology. I conclude with an essential discussion of six blind spots in adenovirology.Adenoviruses (AdVs) are nonenveloped, doublestranded DNA viruses of vertebrates. They are abundant in fish, amphibia, reptilia, birds and mammals, including humans. Currently, about 110 human adenovirus (HAdV) types and genotypes are known and classified into seven species (A-G). AdVs infect the respiratory organs, the eyes, the kidney, the gastrointestinal tract and blood cells. On a population scale, AdVs emerge unpredictable, and can cause human epidemics.The structure of the virion is related to phages of eubacteria and archaea, and is part of an evolutionary lineage comprising the internal membrane-bearing PRD1 phage of the tectiviridae infecting Gram-negative bacteria, paramecium bursaria chlorella virus infecting green algae, sulfolobus turreted icosahedral virus infecting archaea, as well as vaccinia virus, an attenuated form of the cowpox disease virus, related to variola virus causing small pox [1][2][3][4][5]. Both AdVs

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Virus Maturation

Cited by 7 publications

References 190 publications

Broad-Spectrum Virus Trapping with Heparan Sulfate-Modified DNA Origami Shells

Broad-Spectrum Virus Trapping with Heparan Sulfate-Modified DNA Origami Shells

Utilizing Electrochemical Biosensors as an Innovative Platform for the Rapid and On-Site Detection of Animal Viruses

Adenoviruses – Infection, pathogenesis and therapy

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