Virus-lipid interactions

Noll, Hans; Js, Youngner

doi:10.1016/0042-6822(59)90033-9

Cited by 26 publications

(4 citation statements)

References 14 publications

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“…Rather, the virions undergo certain interactions with the methacrylate in the monomeric state or during polymerization. Virus-lipid interactions of influenza viruses were observed by Noll and Younger (6,18). Due to such virus-lipid interactions, the virus could perhaps be coated by the developing polymer to a certain extent during the polymerization process.…”

Section: Figmentioning

confidence: 93%

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New adjuvants on a polymethylmethacrylate base

Kreuter¹,

Speiser²

1976

Infect Immun

121

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A new type of adjuvant using influenza virus as an antigen is presented. The new adjuvant was produced by polymerizing monomeric methylmethacrylate in the presence of the antigen. As a comparison, influenza virus was added to previously polymerized polymethylmethacrylate particles. In animal experiments, the antibody response in mice and guinea pigs was measured. After polymerization in the presence of the antigen, the adjuvant effect was dependent on the methylmethacrylate concentration used, reaching an optimal concentration at 0.5%. This adjuvant preparation was considerably more effective than simple addition of virus to comparable polymethacrylate preparations or to aluminum hydroxide. The latter two adjuvants were approximately equivalent in effectiveness.

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Section: Figmentioning

confidence: 93%

“…The following adjuvants were used: group 1, fluid vaccine without adjuvant; group 2, 0.25% PMMA; group 3, 0.5% PMMA; group 4, 1.0% PMMA; group 5, 2.0% PMMA; group 6, 0.5% PMMA plus 0.5% PAA; group 7, 0.1% AI(OH)3; group 8, complete Freund adjuvant. Groups 1 to 6 were polymerized in presence of the antigen.…”

Section: Downloaded Frommentioning

confidence: 99%

New adjuvants on a polymethylmethacrylate base

Kreuter¹,

Speiser²

1976

Infect Immun

121

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“…HDA is known to absorb virus and disable its infectivity. 18 However, in the nanowire coating, the aliphatic amine has been bonded with the nanowires, making it unavailable for absorbing virus. The binding energy of HDA on Cu is 1.89 eV for Cu(100) and 2.01 eV for Cu(111).…”

Section: Resultsmentioning

confidence: 99%

Sprayable copper and copper–zinc nanowires inks for antiviral surface coating

Pan

Phadke

et al. 2022

RSC Adv.

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“…Our findings are in agreement with those of other studies in which disinfectants with lipophilic properties (phenol homologues) were not active against small (20 to 30 nm), non-enveloped viruses belonging to Picornaviridae and Parvoviridae. [25][26][27] Quaternary ammonium compounds (QAC) are reported to be less effective against hydrophilic, non-enveloped viruses, eg, feline calicivirus, canine parvovirus, and poliovirus. 23,28,29 In the present study, a combination of QAC and glutaraldehyde inactivated 93.54% to 99.81% of SVA, but only after a contact time of 60 minutes.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of three disinfectants against Senecavirus A on five surfaces and at two temperatures

Singh,

Mor,

Aboubakr

et al. 2017

JSHAP

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Objectives: To evaluate the virucidal efficacy of three commercial disinfectants against Senecavirus A (SVA) on five different surfaces at ~25°C and 4°C. Materials and methods: Household bleach, a phenolic disinfectant, and a quaternary ammonium-aldehyde disinfectant were tested at manufacturer’s recommended concentrations against a contemporary strain of SVA on aluminum, stainless steel, rubber, cement, and plastic surfaces at ~25°C and 4°C. Virus propagation and titration were performed on swine testicular cells. Viral titers were calculated before and after exposure to the disinfectant being tested. Results: At ~25°C, household bleach at 1:20 dilution inactivated ≥ 99.99% of the virus within 10 to 15 minutes on aluminum, rubber, and plastic. On stainless steel and cured cement, it inactivated 99.97% and 99.98% of the virus, respectively. At 4°C, bleach inactivated ≥ 99.99% of the virus within 5 to15 minutes on all surfaces except rubber; on rubber, inactivation was 99.91% after 15 minutes. The phenolic disinfectant at the manufacturer’s recommended concentration inactivated only ≤ 82.41% of the virus at either temperature and on any surface, even after a 60-minute contact time. Results for the quaternary ammonium disinfectant were intermediate: 78.12% to 99.81% of the virus was inactivated within 60 minutes at both temperatures and on all surfaces. To detect differences between disinfectants, paired Wilcoxon tests were performed. At 10- and 15-minute time points, efficacies of the three disinfectants differed significantly. Implications: Significant variation exists in the antiviral efficacies of different disinfectants. Hence, they should be tested against various pathogens before use in the field.

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Virus-lipid interactions

Cited by 26 publications

References 14 publications

New adjuvants on a polymethylmethacrylate base

New adjuvants on a polymethylmethacrylate base

Sprayable copper and copper–zinc nanowires inks for antiviral surface coating

Efficacy of three disinfectants against Senecavirus A on five surfaces and at two temperatures

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