New adjuvants on a polymethylmethacrylate base

Kreuter, Jörg; Speiser, P

doi:10.1128/iai.13.1.204-210.1976

Cited by 121 publications

(23 citation statements)

References 8 publications

(7 reference statements)

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“…The nucleic acid-free vaccine did not appear to be as potent as the unfractionated, detergent-lysed virus vaccine. However, the efficacy of this vaccine may be improved by such procedures as protein aggregation or polymerization or combination with immunomodulators, methods that have been successful with experimental virus vaccines (4,13). In addition, a more specific vaccine might be prepared by on September 1, 2020 by guest http://iai.asm.org/ Downloaded from the use of viral glycoprotein subunits (14).…”

Section: Resultsmentioning

confidence: 99%

Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine

Kitces¹,

Morahan²,

Tew³

et al. 1977

Infect Immun

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The effect of immunization with inactivated herpes virus vaccines, including a vaccine free of all nucleic acid, was investigated in a mouse model system. Protection against oral lesions induced by herpes simplex virus type 1 was demonstrated by several criteria: (i) reduction in the incidence and severity of primary oral lesions; (ii) decrease in acute and latent infection of the regional sensory ganglia; and (iii) protection from viral encephalitis and death. The immune response of mice to the vaccine and to subsequent virus challenge was measured by following serum-neutralizing antibody titers.

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Section: Resultsmentioning

confidence: 99%

Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine

Kitces¹,

Morahan²,

Tew³

et al. 1977

Infect Immun

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“…Poly-alkyl acrylate based nanoformulations have been prepared with poly (methylmethacrylate) (PMMA), poly (ethylacrylic acid) (PEAA), poly (propylacrylic acid) (PPAA) and poly (butylacrylic acid) (PBAA). Studies have shown that polyacrylate-based nanoparticles show an inherent adjuvanticity with several model antigens [4,94,95]. The type of polymer used in the nano-formulation strongly affects the structure, properties and applications of the particles.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

et al. 2017

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Synthetic nanoparticles play an increasingly significant role in vaccine design and development as many nanoparticle vaccines show improved safety and efficacy over conventional formulations. These nanoformulations are structurally similar to viruses, which are nanoscale pathogenic organisms that have served as a key selective pressure driving the evolution of our immune system. As a result, mechanisms behind the benefits of nanoparticle vaccines can often find analogue to the interaction dynamics between the immune system and viruses. This review covers the advances in vaccine nanotechnology with a perspective on the advantages of virus mimicry towards immune potentiation. It provides an overview to the different types of nanomaterials utilized for nanoparticle vaccine development, including functionalization strategies that bestow nanoparticles with virus-like features. As understanding of human immunity and vaccine mechanisms continue to evolve, recognizing the fundamental semblance between synthetic nanoparticles and viruses may offer an explanation for the superiority of nanoparticle vaccines over conventional vaccines and may spur new design rationales for future vaccine research. These nanoformulations are poised to provide solutions towards pressing and emerging human diseases.

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“…In the late 70s, the work of Kreuter and Speiser opened the way for the specific use of polymers, such as polymethylmethacrylate, as materials for the engineering of antigen nanocarriers (Kreuter and Speiser, 1976). Since then, a significant number of studies have put in evidence the potential of nanoparticles to enhance the immune response against different antigens in a sustained and prolonged way (Correia-Pinto et al, 2013;González-Aramundiz et al, 2012;Reddy et al, 2006b;Rice-Ficht et al, 2010;Vicente et al, 2010).…”

Section: Nanoengineering Of Vaccines Using Polysaccharidesmentioning

confidence: 99%

Nanoengineering of vaccines using natural polysaccharides

Cordeiro

Alonso

Fuente

2015

Biotechnology Advances

101

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Currently, there are over 70 licensed vaccines, which prevent the pathogenesis of around 30 viruses and bacteria. Nevertheless, there are still important challenges in this area, which include the development of more active, non-invasive, and thermo-resistant vaccines. Important biotechnological advances have led to safer subunit antigens, such as proteins, peptides, and nucleic acids. However, their limited immunogenicity has demanded potent adjuvants that can strengthen the immune response. Particulate nanocarriers hold a high potential as adjuvants in vaccination. Due to their pathogen-like size and structure, they can enhance immune responses by mimicking the natural infection process. Additionally, they can be tailored for non-invasive mucosal administration (needle-free vaccination), and control the delivery of the associated antigens to a specific location and for prolonged times, opening room for single-dose vaccination. Moreover, they allow co-association of immunostimulatory molecules to improve the overall adjuvant capacity. The natural and ubiquitous character of polysaccharides, together with their intrinsic immunomodulating properties, their biocompatibility, and biodegradability, justify their interest in the engineering of nanovaccines. In this review, we aim to provide a state-of-the-art overview regarding the application of nanotechnology in vaccine delivery, with a focus on the most recent advances in the development and application of polysaccharide-based antigen nanocarriers.

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New adjuvants on a polymethylmethacrylate base

Cited by 121 publications

References 8 publications

Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine

Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

Nanoengineering of vaccines using natural polysaccharides

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