Virus-Like Particles in Serum of Patients With Australia-Antigen-Associated Hepatitis

Dane, D. S.; Cameron, C.H.; Briggs, Moya

doi:10.1016/s0140-6736(70)90926-8

Cited by 907 publications

(390 citation statements)

References 4 publications

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“…1 Much of the work on HB5Ag has been directed towards investigating infective properties, and the infectious virus is believed to be the 42 nm Dane particle (Dane, Cameron and Briggs, 1970), the component which, in some cases, contains DNA of 1-6 x 106 daltons (Robinson, Clayton and Greenman, 1974). Genetic material of 'this size can code for the synthesis of about 3 polypeptides, whereas HB,Ag is more complex (Howard and Zuckerman, 1974;Dreesman, Hollinger and Melnick, 1975) and Zuckerman (1974) has suggested that HBV may be classified among the viroids.…”

Section: Methodsmentioning

confidence: 99%

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

Chouroulinkov¹,

Gentil²,

Grover³

et al. 1976

Br J Cancer

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Three dihydrodiols that are metabolites of benzo[a]pyrene and benzo[a]-pyrene itself have been tested in a comparative experiment for their activities as initiators of tumours in mouse skin. A single application (25 mug) of 4,5-dihydro-4,5-dihydroxybenzo[a]pyrene, of 7,8-dihydro-7,8-dihydroxybenzo[a]pyrene, of 9,10-dihydro-9,10-dihydroxybenzo[a]pyrene, or of benzo[a]pyrene was made to the shaved dorsal skin of adult female CDI mice; this was followed 2 weeks later by multiple thrice-or twice-weekly applications (1 mug) of 12-O-tetradecanoyl-phorbol-13-acetate as promoting agent. A control group of 30 mice received the promoting agent alone. The experiments were terminated 52 weeks after initiation. At this stage, all the groups contained mice bearing skin papillomas, some of which had progressed to malignancy. Quantitatively the results show that the 7,8-dihydrodiol is almost as active an initiator of mouse skin tumours as benzo[a]pyrene itself; the 4,5- and 9,10-dihydrodiols were significantly less active. The significance of these results is discussed in relation to the hypothesis that diol-epoxides are important in the metabolic activation of polycyclic hydrocarbons like benzo[a]pyrene. Images Fig. 1 Fig. 2 Fig. 3

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Section: Methodsmentioning

confidence: 99%

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

Chouroulinkov¹,

Gentil²,

Grover³

et al. 1976

Br J Cancer

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“…In individuals, infected with HBV, HBsAg is found predominantly in the form of 22 nm non-infectious particles and also as part of surface antigen present in complete HBV particles 8 . These com-(1) Departamento de Virologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.…”

Section: Introductionmentioning

confidence: 99%

Potential infectivity of blood from HBsAG asymptomatic carriers due to the presence of HBV-DNA and comparison with other markers of hbv infection

Tedeschi

Padilla

Camargo

et al. 1989

Rev. Inst. Med. trop. S. Paulo

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“…Since the discovery of HBV variants, several studies has been carried out that focused on the viral factors affecting disease outcome. [4][5][6][7] On the other hand, some family studies have examined the role of host factors by characterizing the genetic basis for susceptibility to HBV infection. 8 In the last decade several studies have established the significance and influence of host genes on the outcome of viral hepatitis.…”

Section: W Orldwide Hepatitis B Virus (Hbv) Associatedmentioning

confidence: 99%

Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

Biswas

Panigrahi

Pal

et al. 2013

Journal of Clinical and Experimental Hepatology

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Background: Interleukin-1b (IL-1b) is an important member of the family of the proinflammatory cytokines that modulate outcome of hepatitis B virus (HBV) infection. Objectives: This study was designed to investigate the relationship between the polymorphic genotypes of the interleukin-1b (IL-1b) promoter region and the interleukin-1 receptor antagonist gene (IL-1RN) and disease outcome in HBV-infected individuals. Methods: DNA was extracted from 395 study subjects including HBV carriers with varying clinical presentations, as well as healthy controls and spontaneously recovered cases (SRC). Polymorphisms in IL-1b (at position À511) and IL-1RN (variable nucleotide tandem repeats, VNTR) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR based assay respectively. Results: Among the study subjects, different IL-1b (at position À511) (CC, CT and TT) and IL-1RN (1/1, 1/2, 2/2 and 1/3) polymorphic genotypes were found at variable proportions. Logistic regression analysis revealed, no notable difference at the level of IL-1b promoter (P = 0.244; OR = 0.78; 95% CI = 0.52-1.18) or IL-1RN genotype polymorphism (P = 0.840; OR = 1.03; 95% CI = 0.78-1.36) among the HBV carriers and controls or SRC cases. Pairwise proportion testing showed, IL-1b À511 genotype CC was significantly higher among asymptomatic carriers (ASC) in comparison with liver cirrhosis (LC) patients (P value = 0.028) and healthy control group (P-value = 0.036). IL-1RN genotype 2/2 was considerably higher in LC group than SRC as well as control group. Combinations of IL-1b (À511) and IL-1RN polymorphisms were associated with disease progression, such as CC-1/2 with ASC and TT-2/2 with LC. Conclusion: IL-1b polymorphisms are found to be associated with disease severity. Different polymorphic combinations are associated with degree of disease severity. Overall this is the first report from Eastern India, which shows association of IL-1b polymorphisms with HBV-related hepatic complications. ( J CLIN EXP HEPATOL 2013;3:281-287)

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Virus-Like Particles in Serum of Patients With Australia-Antigen-Associated Hepatitis

Cited by 907 publications

References 4 publications

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

Potential infectivity of blood from HBsAG asymptomatic carriers due to the presence of HBV-DNA and comparison with other markers of hbv infection

Association of Interleukin-1β and Gene Polymorphisms with Liver Pathogenesis in Hepatitis B Virus Infection among Eastern Indian Population

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