Virus-Induced Wheezing in Children

Heymann, Peter W.; Zambrano, Juan C.; Rakes, Gary P.

doi:10.1016/s0889-8561(05)70345-3

Cited by 3 publications

(3 citation statements)

References 52 publications

(8 reference statements)

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“…We added quarter and year fixed effects to address the seasonality of asthma exacerbations in the spring and early fall. [24][25][26][27] Countylevel fixed effects for the county of a patient's residence were included to control for changes in local area resources, responding to the fact that a small portion of our patient population moves during the study period, and account for the geographic variations in asthma outcomes and utilization patterns. [28][29][30][31] Finally, we clustered standard errors at the patient level.…”

Section: Discussionmentioning

confidence: 99%

“…We included patient‐level fixed effects to control for both observable and unobservable differences in patient characteristics. We added quarter and year fixed effects to address the seasonality of asthma exacerbations in the spring and early fall 24‐27 . County‐level fixed effects for the county of a patient's residence were included to control for changes in local area resources, responding to the fact that a small portion of our patient population moves during the study period, and account for the geographic variations in asthma outcomes and utilization patterns 28‐31 .…”

Section: Methodsmentioning

confidence: 99%

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Effects of forced disruption in Medicaid managed care on children with asthma

Piwnica-Worms

Staiger

Ross

et al. 2021

Health Services Research

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Objective: To evaluate the effect of a forced disruption to Medicaid managed care plans and provider networks on health utilization and outcomes for children with persistent asthma. Data Sources: Medicaid managed care administrative claims data from 2013 to 2016, obtained from a southeastern state. Study Design: A difference-in-difference analysis compared patients' outpatient, inpatient, and emergency department (ED) utilization and receipt of recommended services before and after implementation of a statewide redistribution of patients among nine managed care plans. Data Collection/Extraction Methods: Enrollment data for children with asthma were linked to the administrative claims. Children were included if they had a diagnosis of persistent asthma in 2013 and if they were enrolled continuously throughout 2014-2016.Principal Findings: Among the 28 537 children with asthma, 26% were forced to switch their managed care plan after the redistribution. Of these, 67% also switched their primary care provider (PCP). Relative to those who remained in their plan, disruption was associated with an additional 2.1 percentage-point decrease in the number of children who had an outpatient visit per quarter [95%CI −2.8, −1.3], from 71% to 66% (compared to plan stayers: 74% to 71%). Among children experiencing a change to their plan, there was overall a decrease in the proportion of children receiving an asthma-specific visit per quarter, but there was less of a decrease in children that also changed their PCP [1.6 percentage points, 95%CI 0.7, 2.5], from 9.7% to 8.3% (compared to those who did not switch their PCP: 12% to 8.6%). Indicators of asthma care quality and emergent care utilization were not significantly different between the two periods. Conclusions:While there was a decrease in the number of outpatient visits associated with forced disruption of Medicaid managed care plans for children with persistent asthma, there were no consistent associations with worse asthma quality performance or higher emergent health care utilization.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of forced disruption in Medicaid managed care on children with asthma

Piwnica-Worms

Staiger

Ross

et al. 2021

Health Services Research

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“…RSV is responsible for the thousands of illnesses with symptoms of headache, cough, fever, chill and sore throat (Xu et al, 2018). The virus infects 90 % of the children by 2 years of age and has been found to be responsible for the exacerbations when the child is suffering from asthma in the following years (Heymann et al, 1998;Wu & Hartert, 2011). Several studies support that children are prone to the onset of asthma and allergy when sensitized by RSV in early childhood especially in infancy (Wang & Forsyth, 1998).…”

Section: Introductionmentioning

confidence: 99%

Detection of Respiratory Syncytial Virus in Suspected Asthmatic Children by Conventional RT-PCR Assays in Kathmandu

Khadka

Sah

Amatya

2023

J. Nepal. Biotech. Assoc.

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Respiratory Syncytial Virus (RSV) is the most common causative agent for lower respiratory tract infections in children particularly in infants. At least 50% of children are infected with RSV by the age of 2 to 3 years of age. However, the diagnosis of the RSV infection and its association with risk factors for asthma in asthmatic children is not studied in Nepal. The objectives of this study were to determine the prevalence of RSV in asthmatic children. This work was a hospital based cross-sectional prospective study and conducted from September 2017 to February 2018. Ethical approval was obtained from the Institutional Review Committee (IRC) of Kanti Children’s Hospital, Maharajgunj. Suspected asthmatic children visiting the Special Asthma OPD of Kanti Children’s Hospital, Maharajgunj were selected with the help of asthma specialist using a set of inclusion criteria for asthma. A total of 32 nasal swab samples were obtained from suspected asthmatic children. Initially, samples were processed for RNA extraction. The extracted RNA was then used for cDNA synthesis followed by PCR using primers for the Nucleocapsid (N) gene of RSV. Out of total 32 samples, 9 (28%) samples were positive for the N gene of RSV. There was no significant association of different variables including age (P=0.187), sex (P=0.264), family history of asthma (P=0.115), passive smoking (P=0.88), birth weight (P=0.954), seasonality (P=0.298) and history of pneumonia (P=0.457) with the RSV infection in this study.

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