Virus Excretion after Mass Vaccination with Attenuated Polioviruses in Hungary

Domok, I; Molnar, E; Jancsó, A

doi:10.1136/bmj.1.5237.1410

Cited by 30 publications

(6 citation statements)

References 3 publications

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“…Virus isolation was performed in primary rhesus monkey kidney (Melnick et al, 1972;Melnick & Wimberly, 1985) and with monovalent type 3 antisera, intratypic serodifferentiation, and characterization of phenotypic markers (McBride, 1959;Nakano et al, 1966) were originally performed in the laboratory of Prof. I. Dömök (Domok et al, 1961(Domok et al, , 1962Dömök, 1971Dömök, , 1984Kátay, 1961). For molecular characterization, isolates (second or third passage in primary monkey kidney cells) were passaged at 37 1C once in L20B (mouse L cells expressing the human poliovirus receptor) and again in RD cells (human rhabdomyosarcoma ATCC CCL 136) to produce high-titer cultures (Pipkin et al, 1993;Wimmer et al, 1993).…”

Section: Virus Isolates and Cell Culturementioning

confidence: 99%

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Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary

Kapusinszky

Molnár

Szomor

et al. 2010

FEMS Immunol Med Microbiol

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Hungarian children were immunized with monovalent oral poliovaccine (mOPV) delivered at 6-week intervals in the order Sabin 1, Sabin 3, Sabin 2, from 1959 until 1992. During that period, 90 cases of vaccine-associated paralytic poliomyelitis (VAPP) were reported, 52 of which were associated with Sabin 3-related virus (76% of VAPP cases with virologic data). Because of renewed interest in type 3 mOPV (mOPV3), molecular methods were used to reanalyze 18 of the Sabin 3-related isolates from 15 VAPP patients, confirming the original identification. All isolates had the U472C 5'-untranslated region (5'-UTR) substitution associated with reversion to neurovirulence, and from zero to seven nucleotide substitutions in the virus protein 1 (VP1) region. No evidence was found for prolonged mOPV3 replication in the VAPP patients or for spread of Sabin 3-related viruses beyond close vaccinee contacts. The VAPP diseases were prevented by a single dose of inactivated poliovirus vaccine from 1992 to 2006 in Hungary, as proved by continuous surveillance of acute flaccid paralysis.

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Section: Virus Isolates and Cell Culturementioning

confidence: 99%

“…Children 2-38 months of age were immunized from December 1959 up to 1992 in mass campaigns. Six weeks elapsed between administration of the individual monovalent doses (Domok et al, 1961(Domok et al, , 1962Fornosi & Talos, 1964-1965Dömök, 1971;Evans et al, 1985). There were two exceptions.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary

Kapusinszky

Molnár

Szomor

et al. 2010

FEMS Immunol Med Microbiol

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“…Every sample was tested in monkey-kidney-cell cultures; those from Gy6r-Sopron county were also tes.ed in suckling mice. The methods have been published elsewhere (Domok et al, 1960).…”

Section: Virus Excretion After Mass Vaccination Withmentioning

confidence: 99%

“…The polio and E.C.H.O. sera were prepared in rabbits, the Coxsackie sera in mice (Domok et al, 1960).…”

Section: Virus Excretion After Mass Vaccination Withmentioning

confidence: 99%

Virus Excretion after Mass Vaccination with Attenuated Polioviruses in Hungary

Domok¹,

Molnar²,

Jancsó³

1961

BMJ

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“…Sabin et al (1960) found that, in Mexico, 50 % of the population excreted non-polio enteric viruses both before and after vaccination while Domok, Molnan & Jancso (1961) found that there was a rapid decrease in Coxsackie and echovirus excretion after the first oral vaccination.…”

Section: Introductionmentioning

confidence: 99%

The feeding of oral poliovirus vaccine to a closed community excreting faecal viruses

Gardner

Cooper

1964

J. Hyg.

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The residential home was investigated to study the endemic virus population. During this study, oral poliovirus vaccine was given to the children and the effect of vaccination on endemic enteroviruses and adenoviruses was investigated. In the light of these findings, the problem of virus interference is discussed. The health of the children is related to their virus infections.We are indebted to Prof. S. D. M. Court and Prof. C. A. Green for the active interest they have taken in this investigation; to Miss J. McQuillin, B.Sc., F.I.M.L.T., for her technical assistance; also to the matron of the home and her staff for their co-operation in supplying the specimens, and to Mr L. J. Whitlock of the Royal Victoria Infirmary and his staff for arranging their transport to the laboratory.

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Virus Excretion after Mass Vaccination with Attenuated Polioviruses in Hungary

Cited by 30 publications

References 3 publications

Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary

Molecular characterization of poliovirus isolates from children who contracted vaccine-associated paralytic poliomyelitis (VAPP) following administration of monovalent type 3 oral poliovirus vaccine in the 1960s in Hungary

Virus Excretion after Mass Vaccination with Attenuated Polioviruses in Hungary

The feeding of oral poliovirus vaccine to a closed community excreting faecal viruses

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