Virus de l’hépatite B au Congo (Brazzaville) : séroprévalence et diversité génétique chez les donneurs de sang en zones hyper endémiques

Atipo-Ibara, B. I.; Itoua-Ngaporo, A.; Dzia-Lepfoundzou, Amelia; Ahoui-Apendi, C.; Deby-Gassaye, C.; Bossali, F.; Rody, S. Ngami; Ennaji, My Mustapha; Boumba, Anicet Luc Magloire; Ibara, Jean-Rosaire

doi:10.1007/s12157-015-0607-7

Cited by 6 publications

(9 citation statements)

References 9 publications

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“…In Congo, many people carry the virus B and/or C [ 19 – 22 ]. However, most of them are unaware of this, believing that the only chronic viral disease is HIV/AIDS [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…The high incidence of HBsAg carriage in blood donors was observed in the Pointe-Noire, Niari and Bouenza departments, confirming Congo’s place in the hyperendemic area of HBV infection. Atipo-Ibara et al [ 22 ] in their study observed the frequence of HBsAg carriage in blood donors in few localities of the country: Pointe-Noire (10.8%), Nkayi (9.3%), Dolisie (8.9%), Madingou (5.9%) and Mouyondzi (5.2%) [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Atipo-ibara et al used only the NS5B region, they obtained sequencing of 17 samples, 16 genotypes 4 (G4) and 1 genotype 2 (G2) [ 22 ]. The distribution of genotype 4 subtypes in this article shows great genetic diversity and predominance of one subtype G4.…”

Section: Resultsmentioning

confidence: 99%

“…At Brazzaville, the seroprevalence rate among 1363 blood donors was documented to be 9.9%. Hepatitis B infection remains also a public health problem in Congo [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of viral hepatitis in the Republic of Congo: review

Linguissi¹,

Nkenfou

2017

BMC Res Notes

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ObjectiveConsidered an endemic zone, Republic of Congo has a high seroprevalence rate of hepatitis B and C virus. To know the extent of hepatitis infection as a public health problem, we reviewed published literature and other sources for reports of these viral infections in the country.ResultsHigh seroprevalence of HBV and HCV carriage in blood donors were observed in studies confirming Congo’s place in the hyperendemic area of HBV and HCV infection. These prevalence were compared by Chi square test. We compared the prevalence of three studies conducted in 1996, 2015 and 2016. The statistical results were very significant. HBV genotype E was most prevalent. Very few studies were done on pregnant women. Difficulties in the care and management of patients were also noted because of the high cost of often unavailable treatments. Difficulties arise, however, when an attempt was made to implement the National Hepatitis Control Program. Despite studies conducted on hepatitis prevalence, health interventions are still needed to care and manage these patients and the need to implement the national hepatitis control is more pressing in the Congo.

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“…In Congo, many people carry the virus B and/or C [ 19 – 22 ]. However, most of them are unaware of this, believing that the only chronic viral disease is HIV/AIDS [ 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…At Brazzaville, the seroprevalence rate among 1363 blood donors was documented to be 9.9%. Hepatitis B infection remains also a public health problem in Congo [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of viral hepatitis in the Republic of Congo: review

Linguissi¹,

Nkenfou

2017

BMC Res Notes

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“…The high prevalence of HBsAg confirms Congo's place among countries with high HBV endemicity according to WHO [10] [11]. This rise can be explained by the absence of a policy to reduce the transmission of hepatitis viruses.…”

Section: Discussionmentioning

confidence: 96%

Seroprevalence and Molecular Biodiversity of Hepatitis B and Delta Virus Infections in the Republic of Congo

Mongo-Onkouo¹,

Okombi²,

Boumba³

et al. 2018

OJGas

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Hepatitis B virus (HBV) infection is a major public health problem in the world. In Congo, studies on the prevalence of HBV infection are common but HDV infection is rare. Objective: Contribute to improve the management and prevention of HBV and HDV infections. Patients and Methods: This was a descriptive and cross-sectional study conducted from January to August 2016 in the health services of the various departments of Congo and at the national public health laboratory in Brazzaville. All patients with HBsAg surface antigen who were at least 18 years old and who consented to the study were included. The HBs antigen was first tested by a rapid test then confirmed by ELISA. All HBsAg positive patients were subsequently subjected to a second ELISA test for Delta antibody. The techniques of extraction and conventional and specific gene amplification were carried out on plasma for the identification of the genotypes of the two viruses. The data analysis was done with EpiInfo V7 software. The proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. Results: 1618 subjects were included, of whom 180 were positive for HBsAg, a frequency of 11.12%. The sex ratio (M/F) was 0.77%, the mean age was 40.2 ± 15.6 years with extremes ranging from 18 to 88 years. Of the 180 HBsAg positive, 22 were anti-VHD positive, a frequency of 12.22%. HBV DNA was amplified in 83.8% (151/180), HDV RNA in 63.6% (14/22). For HBV, three genotypes were identified: E (46.9%), A (43.7%) and D (9.4%), however for VHD three genotypes D1, D5, D8 were identified. Conclusion: Co-infection of hepatitis

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