Virus Capture and Destruction by Label‐Free Graphene Oxide for Detection and Disinfection Applications

Song, Zhiyong; Wang, Xiaoyu; Zhu, Genxing; Nian, Qing-Gong; Zhou, Hangyu; Yang, Dong; Qin, Cheng‐Feng; Tang, Ruikang

doi:10.1002/smll.201401706

Cited by 123 publications

(125 citation statements)

References 43 publications

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“…Comparison experiments confirmed that both the negative charges and nanosheet structure contributed to their antiviral ability . It was further shown that heat treatment could enhance virus capture and even denaturation due to the excellent heat and electron transfer properties of GO or rGO …”

Section: Interactions Between Graphene Derivatives and Pathogensmentioning

confidence: 75%

“…In some other studies, it was reported that the negative charges on GO and rGO along with their unique single‐layer structure were enough to bind and thus suppress the infection of the pseudorabies virus (PRV, a DNA virus) and porcine epidemic diarrhea virus (PEDV, an RNA virus) . Comparison experiments confirmed that both the negative charges and nanosheet structure contributed to their antiviral ability . It was further shown that heat treatment could enhance virus capture and even denaturation due to the excellent heat and electron transfer properties of GO or rGO …”

Section: Interactions Between Graphene Derivatives and Pathogensmentioning

confidence: 89%

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Multivalent Interactions between 2D Nanomaterials and Biointerfaces

et al. 2018

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2D nanomaterials, particularly graphene, offer many fascinating physicochemical properties that have generated exciting visions of future biological applications. In order to capitalize on the potential of 2D nanomaterials in this field, a full understanding of their interactions with biointerfaces is crucial. The uptake pathways, toxicity, long-term fate of 2D nanomaterials in biological systems, and their interactions with the living systems are fundamental questions that must be understood. Here, the latest progress is summarized, with a focus on pathogen, mammalian cell, and tissue interactions. The cellular uptake pathways of graphene derivatives will be discussed, along with health risks, and interactions with membranes-including bacteria and viruses-and the role of chemical structure and modifications. Other novel 2D nanomaterials with potential biomedical applications, such as transition-metal dichalcogenides, transition-metal oxide, and black phosphorus will be discussed at the end of this review.

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Section: Interactions Between Graphene Derivatives and Pathogensmentioning

confidence: 75%

Section: Interactions Between Graphene Derivatives and Pathogensmentioning

confidence: 89%

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

et al. 2018

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“…Vaccines are sensitive to temperature changes; thus, continuous refrigeration facilities are required to maintain their potency . However, some areas lack dependable refrigeration equipment to store and deliver vaccines, and thus, a significant portion are wasted.…”

Section: Biological Strategy For Organism Modificationmentioning

confidence: 99%

“…Many strategies have been employed to stabilize vaccines, including silk, minerals, and sugars. [175b] Among the biogenic stabilizers utilized, CaP are of interest because of their good biocompatibility and are now utilized as a transferring agent and adjuvant to stabilize vaccines. [175b] CaP shells can be introduced onto viral surfaces when the calcium ion concentration is high …”

Section: Biological Strategy For Organism Modificationmentioning

confidence: 99%

Biomineralization: From Material Tactics to Biological Strategy

et al. 2017

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Biomineralization is an important tactic by which biological organisms produce hierarchically structured minerals with marvellous functions. Biomineralization studies typically focus on the mediation function of organic matrices on inorganic minerals, which helps scientists to design and synthesize bioinspired functional materials. However, the presence of inorganic minerals may also alter the native behaviours of organic matrices and even biological organisms. This progress report discusses the latest achievements relating to biomineralization mechanisms, the manufacturing of biomimetic materials and relevant applications in biological and biomedical fields. In particular, biomineralized vaccines and algae with improved thermostability and photosynthesis, respectively, demonstrate that biomineralization is a strategy for organism evolution via the rational design of organism-material complexes. The successful modification of biological systems using materials is based on the regulatory effect of inorganic materials on organic organisms, which is another aspect of biomineralization control. Unlike previous studies, this study integrates materials and biological science to achieve a more comprehensive view of the mechanisms and applications of biomineralization.

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“…Notably, glycerol monolaurate prevented mucosal simian immunodeficiency virus transmission in a rhesus macaque model . While peptides and surfactants have been the main agents explored for virucidal activity and benefit from nanotechnology‐enabled formulations, several nanomaterials themselves have also been reported to destabilize enveloped viruses, including graphene oxide surfaces and silver nanoparticles as well as polymeric thin films . Collectively, there are many opportunities to incorporate membrane‐lytic agents into prophylactic strategies, especially topical and disinfectant applications, and further investigation of therapeutic strategies across the range of lipid envelope‐targeting agents is also warranted for extracellular virion impairment.…”

Section: Nanomedicine Strategiesmentioning

confidence: 99%

Nanomedicine for Infectious Disease Applications: Innovation towards Broad‐Spectrum Treatment of Viral Infections

Jackman

Lee

Cho

2015

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Nanomedicine enables unique diagnostic and therapeutic capabilities to tackle problems in clinical medicine. As multifunctional agents with programmable properties, nanomedicines are poised to revolutionize treatment strategies. This promise is especially evident for infectious disease applications, for which the continual emergence, re-emergence, and evolution of pathogens has proven difficult to counter by conventional approaches. Herein, a conceptual framework is presented that envisions possible routes for the development of nanomedicines as superior broad-spectrum antiviral agents against enveloped viruses. With lipid membranes playing a critical role in the life cycle of medically important enveloped viruses including HIV, influenza, and Ebola, cellular and viral membrane interfaces are ideal elements to incorporate into broad-spectrum antiviral strategies. Examples are presented that demonstrate how nanomedicine strategies inspired by lipid membranes enable a wide range of targeting opportunities to gain control of critical stages in the virus life cycle through either direct or indirect approaches involving membrane interfaces. The capabilities can be realized by enabling new inhibitory functions or improving the function of existing drugs through nanotechnology-enabled solutions. With these exciting opportunities, due attention is also given to the clinical translation of nanomedicines for infectious disease applications, especially as pharmaceutical drug-discovery pipelines demand new routes of innovation.

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Virus Capture and Destruction by Label‐Free Graphene Oxide for Detection and Disinfection Applications

Cited by 123 publications

References 43 publications

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

Multivalent Interactions between 2D Nanomaterials and Biointerfaces

Biomineralization: From Material Tactics to Biological Strategy

Nanomedicine for Infectious Disease Applications: Innovation towards Broad‐Spectrum Treatment of Viral Infections

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