Multivalent Interactions between 2D Nanomaterials and Biointerfaces

Tu, Zhaoxu; Guday, Guy; Adeli, Mohsen; Haag, Rainer

doi:10.1002/adma.201706709

Cited by 120 publications

(86 citation statements)

References 286 publications

(481 reference statements)

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“…The aggregation of 2D nanomaterials in physiological environments caused by their large surface areas or hydrophobicity hindered their biomedical applications . To meet the increasing demand for biomedicine, it is necessary to modify 2D materials physically or chemically to improve their dispersity and biocompatibility.…”

Section: Modification Of 2d Nanomaterialsmentioning

confidence: 99%

Two‐Dimensional Nanomaterials for Photothermal Therapy

2020

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Two‐dimensional (2D) nanomaterials are currently explored as novel photothermal agents because of their ultrathin structure, high specific surface area, and unique optoelectronic properties. In addition to single photothermal therapy (PTT), 2D nanomaterials have demonstrated significant potential in PTT‐based synergistic therapies. In this Minireview, we summarize the recent progress in 2D nanomaterials for enhanced photothermal cancer therapy over the last five years. Their unique optical properties, typical synthesis methods, and surface modification are also covered. Emphasis is placed on their PTT and PTT‐synergized chemotherapy, photodynamic therapy, and immunotherapy. The major challenges of 2D photothermal agents are addressed and the promising prospects are also presented.

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Section: Modification Of 2d Nanomaterialsmentioning

confidence: 99%

Two‐Dimensional Nanomaterials for Photothermal Therapy

2020

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“…[34] Inter action of GO with cells is not only important in biosensing, but also in many other related applications such as bioimaging, therapy, drug delivery which are of great interest in biomedical applications (together with biosensing/digansotics), and theranostic platforms/systems. Tu et al have widely discussed the interaction of graphene derivatives and biointerfaces, particularly pathogen, mammalian cells, and tissue.…”

Section: Lateral Sizementioning

confidence: 99%

“…Tu et al have widely discussed the interaction of graphene derivatives and biointerfaces, particularly pathogen, mammalian cells, and tissue. [34] Inter action of GO with cells is not only important in biosensing, but also in many other related applications such as bioimaging, therapy, drug delivery which are of great interest in biomedical applications (together with biosensing/digansotics), and theranostic platforms/systems. [35] Interestingly, biocompatibility and cellular uptake, which is pivotal in cell biosensors, have also been reported to be related to GO lateral size.…”

Section: Lateral Sizementioning

confidence: 99%

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

2018

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IntroductionAs a 2D material, graphene oxide (GO) is a lattice-like nanostructure of hexagonal carbon rings disrupted by oxygen-containing moieties. In 2012, we discussed the outstanding physicochemical properties offered by GO and how these features can be exploited in unprecedented optical biosensing systems. [1] In fact, GO can be processed in suspension, easily complexed with biomolecules, and offers a universal highly efficient long-range photoluminescence quenching agent-among other functional properties. Furthermore, we highlighted that GO photoluminescences with energy transfer donor/acceptor molecules exposed A few years ago, crucial graphene oxide (GO) features such as the carbon/oxygen ratio, number of layers, and lateral size were scarcely investigated and, thus, their impact on the overall optical biosensing performance was almost unknown. Nowadays valuable insights about these features are well documented in the literature, whereas others remain controversial. Moreover, most of the biosensing systems based on GO were amenable to operating as colloidal suspensions. Currently, the literature reports conceptually new approaches obviating the need of GO colloidal suspensions, enabling the integration of GO onto a solid phase and leading to their application in new biosensing devices. Furthermore, most GO-based biosensing devices exploit photoluminescent signals. However, further progress is also achieved in powerful label-free optical techniques exploiting GO in biosensing, particularly using optical fibers, surface plasmon resonance, and surface enhanced Raman scattering. Herein, a critical overview on these topics is offered, highlighting the key role of the physicochemical properties of GO. New challenges and opportunities in this exciting field are also highlighted.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805043.in a planar surface. [1] However, GO properties can be tailored according to its oxidation degree, lateral size, and number of layers, which was something little explored 6 years ago, and thus their impact on the overall biosensing performance was almost unknown. In addition, most of the biosensing systems based on GO were amenable to working as colloidal suspensions. Though, recent literature reports conceptually new approaches obviating the need of colloidal suspensions, which facilitates integration of GO-based biosensors into the solid phase and allows for their applications in new devices. Furthermore, the majority of the GO-based optical biosensing techniques rely on photoluminescent signals. However, further progress has also been achieved in powerful label-free optical techniques exploiting GO in biosensing. Here, we introduce a progress report on this exciting topic, underscoring challenges and opportunities in (bio)sensing accordingly. Number of LayersGO aqueous suspensions are highly stable in the form of mono layers. However, GO multilayer films can be built via

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“…Two-dimensional (2D) nanomaterials,referring to the sheets or plate-like solids with at hickness of one or several atoms, have attracted dramatically increasing interest in the last 15 years. [1] Especially,s everal kinds of 2D nanomaterials including carbon-based 2D materials,transition metal dichalcogenides/oxides,l ayered double hydroxides,a nd black phosphorus,h ave been employed for various biological applications (biosensing/bioimaging, [2] tissue engineering, [3] and drug delivery [4] )b ecause of their extremely high surface-to-volume ratio and anisotropic physical/chemical properties.…”

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confidence: 99%

Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO₂ Nanosheet Supraparticles at the Single‐Particle Level

et al. 2019

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We herein demonstrate robust two‐dimensional (2D) UFO‐shaped plasmonic supraparticles made of gold nanoparticles (AuNPs) and MnO2 nanosheets (denoted as AMNS‐SPs) for directly monitoring cell membrane vesiculation at the single‐particle level. Because the decorated MnO2 nanosheets are ultrathin (4.2 nm) and have large diameters (230 nm), they are flexible enough for deformation and folding for parceling of the AuNPs during the endocytosis process. Correspondingly, the surrounding refractive index of the AuNPs increases dramatically, which results in a distinct red‐shift of the localized surface plasmon resonance (LSPR). Such LSPR modulation provides a convenient and accurate means for directly monitoring the dynamic interactions between 2D nanomaterials and cell membranes. Furthermore, for the endocytosed AMNS‐SPs, the subsequent LSPR blue‐shift induced by etching effects of reducing molecules is promising for exploring the local environment redox states at the single‐cell level.

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Multivalent Interactions between 2D Nanomaterials and Biointerfaces

Cited by 120 publications

References 286 publications

Two‐Dimensional Nanomaterials for Photothermal Therapy

Two‐Dimensional Nanomaterials for Photothermal Therapy

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO₂ Nanosheet Supraparticles at the Single‐Particle Level

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Multivalent Interactions between 2D Nanomaterials and Biointerfaces

Cited by 120 publications

References 286 publications

Two‐Dimensional Nanomaterials for Photothermal Therapy

Two‐Dimensional Nanomaterials for Photothermal Therapy

Graphene Oxide as an Optical Biosensing Platform: A Progress Report

Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO2 Nanosheet Supraparticles at the Single‐Particle Level

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Direct Monitoring of Cell Membrane Vesiculation with 2D AuNP@MnO₂ Nanosheet Supraparticles at the Single‐Particle Level