Virulence traits and plasmid-mediated quinolone resistance among Aggregatibacter actinomycetemcomitans from Iraq: Low rate of highly virulent JP2 genotype

Al-Awsi, Ghaidaa Raheem Lateef; Al-Hadeithi, Zeina S. M.; Jasim, Saade Abdalkareem; Alkhudhairy, Miaad K.; Ghasemian, Abdolmajid

doi:10.1016/j.micpath.2022.105438

Cited by 4 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biofilms are still considered as a major cause of chronic infections (such as chronic periapical periodontitis, chronic lung infection, infective endocarditis, etc.) [ 1 , 2 , 3 , 4 , 5 ]. Additionally, biofilms cause extensive damage to the marine environment and agriculture [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle

Liu

Xie

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

Biofilm is a crucial virulence factor for microorganisms that causes chronic infection. After biofilm formation, the bacteria present improve drug tolerance and multifactorial defense mechanisms, which impose significant challenges for the use of antimicrobials. This indicates the urgent need for new targeted technologies and emerging therapeutic strategies. In this review, we focus on the current biofilm-targeting strategies and those under development, including targeting persistent cells, quorum quenching, and phage therapy. We emphasize biofilm-targeting technologies that are supported by blocking the biofilm life cycle, providing a theoretical basis for design of targeting technology that disrupts the biofilm and promotes practical application of antibacterial materials.

show abstract