Virulence of fungal spores determined by tracheal inoculation of goats following inhalation of aerosolized sterile feedyard dust

Purdy, Charles W.; Layton, Robert C.; Straus, David C.; Ayers, J. R.

doi:10.2460/ajvr.2005.66.615

Cited by 5 publications

(7 citation statements)

References 58 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Moreover, tracheal instillation of spores of fungi commonly found in feedlot dust did not induce AIP in goats. 26 These studies suggest that feedlot dust exposure alone is unlikely to cause AIP.…”

Section: Feedlot Acute Interstitial Pneumoniamentioning

confidence: 96%

Feedlot Acute Interstitial Pneumonia

Woolums

2015

Veterinary Clinics of North America: Food Animal Practice

View full text Add to dashboard Cite

Section: Feedlot Acute Interstitial Pneumoniamentioning

confidence: 96%

Feedlot Acute Interstitial Pneumonia

Woolums

2015

Veterinary Clinics of North America: Food Animal Practice

View full text Add to dashboard Cite

“…The following study demonstrates the dynamics and detection of MTM tissue loading using a commercially available assay in a goat model (41). Previous work in our laboratory has shown the virulence of feed lot dustassociated, fungal conidia as well as the animal's response to these fungi (42). The results showed that SC was among the most virulent fungi tested in the caprine transtracheal model.…”

Section: Detection Of Macrocyclic Trichothecene Mycotoxin In a Caprine (Goat) Instillation Modelmentioning

confidence: 88%

The possible role of fungal contamination in sick building syndrome

Straus

2011

Front Biosci

View full text Add to dashboard Cite

The following is a review of some of the work that we have done since 2007 regarding the importance of molds in the phenomenon of sick building syndrome (SBS). In these studies we first examined mold contamination in air handling units (AHU). Our results showed that Cladosporium sp. were commonly recovered in AHU as growth sites and free spores. They were found mainly on the blower wheel fan blades, the ductwork, and cooling coil fans. Our results showed that the presence of species of molds other than Cladosporium in locations other than the blower wheel blades indicated that the AHU condition was not optimal. In a series of three papers, we examined growth and mycotoxin production by Chaetomium globosum (CG). In these studies we showed that CG produces two potent mycotoxins, chaetoglobosin A (Ch-A) and chaetoglobosin C (Ch-C) when grown on building material. We discovered that these toxins break down when exposed to temperatures in excess of 75 degrees C. We also showed that growth and mycotoxin production by CG is favored at a neutral pH. In another study, we showed that mycotoxins can be detected in body fluids and human tissues from patients exposed to mycotoxin producing molds, and we showed which human tissues or fluids were the most likely to give positive results for detection of these compounds. Finally, we showed that the macrocyclic trichothecene mycotoxins (MTM) produced by Stachybotrys chartarum (SC) are detectable in experimental animals soon after exposure and we described the dynamics of MTM tissue loading.

show abstract

“…As in previous experiments, 8,12,13 dust samples were collected in the tent to determine the amount of dust that settled from the air. A 5-stage cyclone device hh attached to a vacuum pump ii (suction rate, 28.4 L/min) was used to collect fine dust particles (5.2 to 0.32 µm in diameter) during each 4-hour exposure.…”

Section: Methodsmentioning

confidence: 99%

“…Preparation of spores has been described in detail. 8 Briefly, spores were separated from hyphae by use of a sieve and were counted in a hemacytometer. Spore suspensions were titrated in triplicate on malt extract agar Petri plates.…”

Section: Methodsmentioning

confidence: 99%